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Table 2 Factors playing a role in the effectiveness of interferon therapy in patients with chronic hepatitis C according to their response to IFN-α therapy and in untreated controls.

From: Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4

Factor

Responders (n = 15)

#Non-responders (n = 7)

untreated controls (n = 9)

P value*

Age (mean ± SD)

42 ± 6.8

42.5 ± 3.2

43.6 ± 4.5

0.78

M:F

11:4

7:0

9:0

0.15

Mean Weight

83.3 ± 13.6

90 ± 11.9

87.2 ± 8.7

0.562

Blood picture:

    

WBCs

7 ± 2.4

6.3 ± 1.9

5.3 ± 1

0.119

HGB

14.4 ± 1.7

15 ± 1.2

14.4 ± 1

0.495

PLT

208.9± 55.7

187.6 ± 49.2

175.2 ± 43.1

0.448

Liver function tests:

    

AST

91.1 ± 46.6

63.1 ± 26.6

70.2 ± 29.5

0.282

ALT

140 ± 111

83.5 ± 45.2

92.5 ± 43.4

0.361

Albumin

4.57 ± 0.39

4.46 ± 0.46

4.48 ± 0.43

0.836

PT

12.0 ± 0.65

12.2 ± 0.87

12.1 ± 0.77

0.953

INR

1.07 ± 0.1

1.1 ± 0.13

1.07 ± 0.1

0.856

Iron

117 ± 37.5

129 ± 34

117 ± 35

0.812

Ferritin

311 ± 243

504 ± 864

444 ± 760

0.702

Kidney function tests:

    

Urea

28.5 ± 6.7

28.7 ± 4.6

29.6 ± 5.9

0.959

Creatinine

0.88 ± 0.18

0.91 ± 0.17

0.87 ± 0.15

0.807

Liver echogenicity:

    

HAI

5.6 ± 2.7

6.7 ± 3.4

5.8 ± 2.6

0.764

Fibrosis score

1.1 ± 0.9

2.9 ± 1.8

2.1 ± 1.6

0.026*

  1. # Non-responders include I non responder and 6 viral breakthrough patients
  2. * P value is significant between responder and non-responders