Figure 5
From: Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein
Proposed models of the C-terminus of TM. Proposed models of LLP domains in the context of TM and in a lipid membrane. a) A nine pass transmembrane configuration and b) Association of the LLP domains with the inner leaflet of the lipid membrane allowing for interaction with calmodulin. It is possible that the LLP domains flip-flop between this configuration and a transmembrane configuration.