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Table 4 Simplification of Table 3 by removal of slightly overlapping mIMRs

From: Imperfect DNA mirror repeats in the gag gene of HIV-1 (HXB2) identify key functional domains and coincide with protein structural elements in each of the mature proteins

Rank

mIMR

prot

len

DNA positions

AA positions

Structure or function

1

#1-gag

MA

95

0270-aa..ca-0364

091-RI..DT-122

MA-H5 related to viral entry

2

#2-gag

CA

87

0742-gg..tg-0828

248-GW..RM-276

CA-H7 longest constituent of viral core

3

#3-gag

p1

85

1256-aa..aa-1340

419-EG..GN-447

end NC, p1 to p1-p6 cleavage site

4

#6-gag

NC

81

1171-aa..ga-1251

391-KC..CG-417

1st cys-his box; EF1α binding

5

#7-gag

p2

80

1065-ac..ca-1144

356-PG..GN-382

p2, critical to budding

6

#10-gag

CA

76

0812-at..ta-0887

271-NK..DY-296

major homology region

7

#11-gag

CA

75

0920-ag..ga-0994

307-EQ..KT-332

endocytosis signal 1; CA-H9 helix

8

#14-gag

CA

69

0985-ga..ag-1053

329-DC..QG-351

endocytosis signal 2; CA-H10 helix

9

#15-gag

CA

64

0543-ca..aa-0606

181-PQ..LK-202

CA-H3-H4 helices, part of viral core

10

#17-gag

NC

64

1362-gc..ag-1425

455-PT..QK-475

L-domain (budding); Tsg101

     

455-PT..QK-475

docking; ubiquitin-gag conjugate

11

#1-NC

NC

59

1209-aa..aa-1267

404-NC..QM-423

2cd cys-his box; end NC

12

#2-NC

NC

47

1153-aa..ca-1199

385-NQ..GH-400

EF1α binding

  1. MIMRs that begin and end within two amino acids of a larger mIMR have been removed. Although the distribution of mIMRs is nearly continuous throughout gag, the functional and/or structural association of each is discrete, as indicated by the structure-function notation in the right hand column of this table, which is described in greater detail in Additional File 1.