The simultaneous presence and expression of human hepatitis C virus (HCV), human herpesvirus-6 (HHV-6), and human immunodeficiency virus-1 (HIV-1) in a single human T-cell

Table 1 Summary of viral transmission experiments with various hematopoetic and liver cells

	HCV short term	HCV long term	HIV	HHV-6
A. T-cells ¹	+	-	+	+
B. B-cells ²	+	+	-	-
C. Monocytes/macrophages ³	+	-	+	+
D. Neuronal precursors ⁴	+	+	+	+
E. Liver cells ⁵
Kupffer's	+	-	+	+/-
Hepatocytes	+	+/-	-	-

¹T-cells isolated from human fetal chord blood.
²B-cells immortalized by infection with transforming EBV.
³Monocyte/Macrophages, adherent cells stimulated with PMA.
⁴Recently isolated neuronal cells from fetal human brain.
⁵Freshly isolated liver cells from liver biopsies. Kupffer's cells are liver macrophages and Hepatocytes are liver endothelial cells.

ISSN: 1743-422X