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Table 2 Serial isolates or passages from the same or related solid organ transplant recipients.a

From: Analysis of the human cytomegalovirus genomic region from UL146 through UL147A reveals sequence hypervariability, genotypic stability, and overlapping transcripts

Isolate number

Subjects

Donor/Recipient

Specimen type

Days post transplant

Passage

Strain

Relationship among strains

C307

N

D+R-

urine

68

3

N1

Unchanged UL146 sequences in isolates from individual subjects (N, P, G, F, T) after multiple passages in cell culture

C322

N

 

urine

68

13

N1

 

X121

P

D+R+

urine

74

0

P1

 

C336

P

 

urine

74

6

P1

 

C956

P

 

urine

74

32

P1

 

C2571

G

D+R+

urine

54

3

G1

 

C952

G

 

urine

54

24

G1

 

C194

F

D+R+

urine

101

5

F1

 

C875

F

 

urine

101

9

F1

 

C184

T

D+R-

urine

54

3

T1

 

C221

T

 

urine

54

22

T1

 

C108

R1

D+R+

blood

108

30

W1

R1 and R2 received kidneys from same donor

C246

R1

 

blood

108

47

W1

 

C124

R1

 

urine

234

5

W1

 

C345

R1

 

urine

234

29

W1

 

C237

R1

 

urine

92

7

W3

Two different strains W1 and W3 shed by subject R1

X163

R1

 

urine

150

0

W3

 

C101

R1

 

urine

234

5

W3

 

C201

R1

 

urine

234

29

W3

 

X199

R2

D+R-

urine

171

0

W1

Single strain W1 in these specimens from subject R2, but other specimens contained both W1 and W3 from the common donor

X89

R2

 

urine

255

0

W1

 

C239

R2

 

urine

2 years

15

W1

 

C3

L

D+R+

urine

111

12

L1

L and Z received kidneys from same donor

C1917

Z

D+R-

urine

216

9

L1

 

C198

Z

 

urine

2.6 years

4

L1

 

X162

C

D+R+

urine

55

0

C1

C and Y received kidneys from same donor.

C118

C

 

urine

55

4

C1

 

C954

C

 

urine

55

16

C1

 

C69

Y

D+R-

urine

21

4

C1

 

C172

Y

 

urine

21

8

C1

 

CH1-A

CH1

D+R-

BAL

1.1 years

>10

CH1-1

CH1 and CH2 received lungs from same donor.

CH1-B

CH1

 

BAL

4.5 years

8

CH1-1

 

CH2-A

CH2

D+R-

BAL

150

>10

CH1-1

 

NW23-A

NW23

D+R+

colon

1 year

5

NW23-1

Strain NW23-1 phylogenetically different from NW23-2. Specimens NW23-B and NW23-C collected 5 1/2 years apart.

NW23-B

NW23

 

BAL

1.6 years

5

NW23-2

 

NW23-C

NW23

 

BAL

7 years

5

NW23-2

 
  1. aSpecimens designated with C, CH, or NW were cultured. Specimens designated with X were analyzed directly.
  2. All strains with the same strain designation had identical nucleotide sequences in UL146. Overall identity of strains from recipient pairs C/Y, L/Z, R1/R2, and CH1/CH2 with common donors was documented by Southern blot analysis [32, 48].
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Virology Journal

ISSN: 1743-422X