Figure 4
From: Differential localization of HPV16 E6 splice products with E6-associated protein
A model for regulation of E6 protein function by E6*I. E6*I protein binds to E6 or E6AP in the nucleus and cytoplasm. The binding may lead to the inhibition of E6-E6AP binding as well as inhibition of binding of E6 or E6AP to other cellular targets. In this manner, E6*I may inhibit either E6-induced or E6AP-dependent proteosome degradation function or, in fact, inhibit other functions of either E6 or E6AP. The question mark (?), represents other E3 ubiquitin ligases enzymes participating in E6-mediated degradation or E6AP-independent, E6-induced protein degradation.