Figure 3

Structural sequence alignment of the RTBV protease with other retroviral proteases. Sequence alignment of the RTBV protease amino acid sequence with proteases of Rous sarcoma virus (RSV), Equine infectious anemia virus (EIAV) and Human immunodeficiency virus (HIV). The color scheme corresponds to percentage of similarity (based on physico-chemical properties). Black background and white foreground indicate 100%, grey background and white foreground indicate 80%, grey background and black foreground indicate 60%. Lower similarity values are not shown. Numbers over the alignment indicate the alignment length. Secondary structure elements from the RSV sequence are represented over the alignment. The numbering of the elements follows the RSV numbering based on structure. Boxes indicate beta strand elements assigned as β. The helix is represented as a cylinder and indicated as α. Thick lines connecting the elements are loops and dashed lines indicate a break in the sequence. The black triangle indicates the location of the active site.