Development of an immunochromatography strip test based on truncated nucleocapsid antigens of three representative hantaviruses

Table 1 Comparison of reactivities of HFRS, NE and HPS patient sera in ICG tests and ELISA

Type of disease	Infected with	Phase	No. serum	ELISA		Single antigen-strip			Three-line strip			Mixed-line strip (+)
Type of disease	Infected with	Phase	No. serum	IgG (+)	IgM (+)	HTNV (+)	PUUV (+)	ANDV (+)	HTNV (+)	PUUV (+)	ANDV (+)	Mixed-line strip (+)
HFRS	HTNV or SEOV	acute	21	19	17	21 (100%)	1 (4.7%)	1 (4.7%)	21 (100%)	1 (4.7%)	0 (0%)	20 (95%)
HFRS	HTNV or SEOV	conv.^a	35	35	20	35 (100%)	1 (2.8%)	0 (0%)	35 (100%)	1 (2.8%)	0 (0%)	35 (100%)
NE	PUUV	acute	26	21	24	0 (0%)	24 (92.3%)	2 (7.7%)	1 (3.8%)	23 (88.5%)	10 (38.5%)	24 (92.3%)
NE	PUUV	conv.	36	36	5	0 (0%)	35 (97.2%)	17 (47.2%)	0 (0%)	36 (100%)	7 (19.4%)	35 (97.2%)
HPS	SNV, ANDV or LANV	acute	12	7	4	0 (0%)	4 (33.3%)	12 (100%)	0 (0%)	3 (25%)	12 (100%)	12 (100%)
HPS	SNV, ANDV or LANV	conv.	16	16	3	0 (0%)	10 (62.5%)	16 (100%)	0 (0%)	8 (50%)	16 (100%)	16 (100%)
Seronegative healthy donar	-	-	25	0	0	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)

^aConvalescent.
Twenty-one HFRS patient sera from China, 9 NE patient sera from Germany, 35 NE patient sera from Sweden, 11 HPS patient sera from U. S. A., and 17 HPS patient sera from Argentina were used in this study.

ISSN: 1743-422X