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Table 2 List of top 20 most significantly regulated genes

From: Transcriptional profiling of the host cell response to feline immunodeficiency virus infection

Gene symbol

Fold change

Log2read counts

Adjusted p-value

Validation by RT-qPCR

  

Mock

FIV 24 hpi

  

OASL

3.438

8.558

10.340

2.82E-07

Yes

ACHE

2.618

8.011

9.400

2.16E-06

Yes

DHX58

2.578

11.431

12.797

4.98E-06

No

DDX58

2.842

7.276

8.783

6.51E-06

No

TGM2

5.425

4.792

7.231

8.45E-06

Yes

HMGN2

-2.061

12.013

10.969

9.68E-05

Yes

CDKN1A

2.083

9.092

10.152

1.40E-04

Yes

ZFP36

2.040

7.806

8.834

2.98E-04

Yes

BCL6

2.102

3.744

4.817

3.32E-04

Yes

ASB2

5.465

3.050

5.500

3.72E-04

No

CSF1

2.042

7.056

8.087

3.91E-04

Yes

FITM1

2.082

2.227

3.286

4.69E-04

No

IFI44

2.587

4.470

5.841

1.75E-03

Yes

TP53INP1

2.226

4.988

6.143

1.77E-03

No

BMF

2.281

3.717

4.907

1.85E-03

No

SPINK4

-2.896

3.157

1.623

2.28E-03

No

HSPE1

2.985

3.005

4.583

3.20E-03

No

COA1

-2.516

3.559

2.227

3.54E-03

No

CXCL11

3.130

0.750

2.396

4.16E-03

Yes

ERBB2

2.312

1.123

2.333

5.42E-03

No

  1. Most significantly regulated genes in FIV infected cells at 24 hpi as detected by RNA-seq. Fold changes were obtained by comparison of the mean read counts of FIV vs. mock infected cells. Genes were ranked according to the p-values.