Promoter hypermethylation of Wnt pathway inhibitors in hepatitis C virus - induced multistep hepatocarcinogenesis

Table 3 Comparison of patient groups for significance of difference in methylation

Comparison	SFRP2	DKK1	Significance
			SFRP2	DKK1
Normal vs Chronic hepatitis	0.0136	0.0084	Yes	Yes
Normal vs Liver cirrhosis	0.0004	0.0039	Yes	Yes
Normal vs HCC	<0.0001	<0.0001	Yes	Yes
Chronic hepatitis vs Liver cirrhosis	0.2310	0.6784	No	No
Chronic hepatitis vs HCC	<0.0001	0.2832	Yes	No
Liver cirrhosis vs HCC	0.0013	0.7462	Yes	No

Table 3 summarizes the group wise comparisons carried out using non parametric two tailed Mann–Whitney U test.

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