Figure 6

Performance of RAL linear regression model on population seen data. (A) R² performance of linear model on patient genotypes without mixtures was 0.95. (B) Scatterplot of measured FC vs. predicted FC for genotypes containing mixtures from 39 clinical isolates. Error bars are drawn to indicate the uncertainty of the second order linear model prediction as the true mixture frequencies are unknown. For the three outliers identified, each containing a mixture at a primary mutation in the population genotype, the percentage of clones containing that particular primary mutation was: 0% (0/5, 148R), 50% (1/2, 143R) and 100% (2/2, 148R).