Table 1 Analytical specificity and sensitivity of the DBS eluate testing for markers of HBV, HCV and HIV infections compared to serum analyses
Parameters | Serum | DBS eluates | Specificity (%)/ 95% CIa) | Sensitivity (%)/ 95% CIa) | ||
|---|---|---|---|---|---|---|
n. d. (N) | pos. (N) | n. d. (N) | pos. (N) | |||
HBV | ||||||
HBsAg | 159 | 140 | 161 | 138 | 100/97.7 – 100 | 98.6/94.9 – 99.8 |
Anti-HBc | 101 | 204 | 129b) | 176b) | 100/97.2 – 100 | 86.3/83.0 – 91.8b) |
107c) | 198c) | 97.1/93.9 – 99.0c) | ||||
Anti-HBs | 153 | 157 | 162b) | 148b) | 100/97.6 – 100 | 94.3/90.0 – 97.5b) |
157c) | 153c) | 97.5/93.8 – 99.3c) | ||||
HBV DNA | 50 | 100 | 107 | 93 | 100/96.1 – 100 | 93.0/92.9 – 93.1 |
HCV | ||||||
Anti-HCV | 160 | 179 | 164 | 175 | 100/97.7 – 100 | 97.8/96.0 – 100 |
HCV RNA | 50 | 100 | 50 | 100 | 100/96.1 – 100 | 100/98.0 – 100 |
HIV | ||||||
HIV-1-p24/anti-HIV 1/2 | 97 | 112 | 97 | 112 | 100/96.3 – 100 | 100/96.8 – 100 |