Table 1 Histopathological assessments of adult and suckling mice following intranasal infection
Tissue | T1L virus infection | T3D virus infection |
|---|---|---|
Adult Lung | severe patchy pneumonia, alveolar debris, lymphocytic infiltration, distended bronchioles and alveoli | mild to moderate pneumonia, discrete lymphocytic infiltration |
Adult brain | appears normal | appears normal |
Adult liver | few necrotic foci with cell degeneration and polymorphonuclearleukocytes | edema, necrotic foci (fewer than T1L) |
Adult heart | appears normal | appears normal |
Adult spleen | numerous white follicles | numerous white follicles |
Adult intestine | appears normal | appears normal with some lymphocytes |
Suckling lung | severe pneumonia as seen for the adult infection | moderate pneumonia |
Suckling brain | minor areas of lymphocytes | encephalitis, dark staining condensed cells |
Suckling liver | necrotic foci and lymphocytes | less numerous necrotic foci and lymphocytes |