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Table 2 Cluster analysis of infection-induced gene expression changes

From: Comparison of host cell gene expression in cowpox, monkeypox or vaccinia virus-infected cells reveals virus-specific regulation of immune response genes

 

Leading terma

No. of genesb

Group p-value

Term p-valueb

CPXV

blood vessel development

49

4.8 × 10-11

7.6 × 10-9

negative regulation of protein kinase activity

25

1.4 × 10-14

1.1 × 10-8

myeloid cell differentiation

22

6.5 × 10-4

5.4 × 10-3

negative regulation of protein serine/threonine kinase activity

22

8.0 × 10-18

1.1 × 10-10

ERK1 and ERK2 cascade

20

1.7 × 10-11

3.8 × 10-6

regulation of ERK1 and ERK2 cascade

19

1.8 × 10-12

1.3 × 10-6

regulation of actin cytoskeleton organization

18

1.1 × 10-4

4.5 × 10-3

negative regulation of MAP kinase activity (gene set 1)

17

4.4 × 10-8

1.0 × 10-8

negative regulation of MAP kinase activity (gene set 2)

17

1.4 × 10-11

1.0 × 10-8

regulation of leukocyte migration

14

6.2 × 10-8

5.5 × 10-5

negative regulation of hormone secretion

13

4.6 × 10-5

1.0 × 10-6

negative regulation of Wnt receptor signalling pathway

11

4.2 × 10-3

1.1 × 10-1

nephron development

11

2.4 × 10-5

3.8 × 10-2

positive regulation of nitric oxide biosynthetic process

10

5.0 × 10-6

2.5 × 10-5

positive regulation of transmission of nerve impulse

9

7.7 × 10-4

3.9 × 10-3

positive regulation of mitosis

7

2.2 × 10-6

1.8 × 10-2

negative regulation of insulin receptor signalling pathway

6

n.a.c

1.3 × 10-2

MPXV

positive regulation of NF-κB transcription factor activity

12

1.8 × 10-16

5.3 × 10-8

negative regulation of intracellular protein kinase cascade

11

n.a.c

2.6 × 10-6

negative regulation of hormone secretion

10

n.a.c

3.3 × 10-9

negative regulation of MAP kinase activity

8

n.a.c

1.8 × 10-5

cellular response to lipopolysaccharide

8

9.3 × 10-9

8.1 × 10-5

positive regulation of Rho GTPase activity

7

n.a.c

2.7 × 10-4

astrocyte differentiation

6

n.a.c

2.0 × 10-4

regulation of gliogenesis

6

n.a.c

1.3 × 10-3

VACV

negative regulation of MAPK cascade

12

7.0 × 10-6

2.5 × 10-4

ovum-producing ovary development

8

n.a.c

4.8 × 10-2

potassium ion transmembrane transport

6

n.a.c

4.1 × 10-2

cellular potassium ion transport

6

n.a.c

4.1 × 10-2

  1. a Overrepresented biological processes identified by GO clustering of the genes affected by CPXV, MPXV or VACV infection. Related terms were merged into functional groups to reduce redundancy, and the most significant term of the group was defined as group-leading term.
  2. b The degree of connectivity between terms is calculated using κ statistics, and the calculated κ score is also used for defining functional groups. Shown are the identified overrepresented processes, the number of infection-regulated genes assigned to that process and the term p-values.
  3. cn.a. = not applicable. Only term p-values are given if no grouping was done.
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Virology Journal

ISSN: 1743-422X