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Table 1 Pandemic influenza A (H1N1) viruses characterized by Sanger sequencing for amino acid position 222 of the HA

From: A (H1N1) pdm09 HA D222 variants associated with severity and mortality in patients during a second wave in Mexico

HA position 222 codon

Clinical outcome

 

Mild (n  =  27)

Severe (n =  26)

Fatal (n =  24)

222D (wt)

100% (27)

84. 6% (22)

58. 2% (14)

222D, 222E, 222G, 222N

0% (0)

7.7% (2)

8.4% (2)

222G

0% (0)

0% (0)

12.5% (3)

222D, 222G

0% (0)

7.7% (2)

12.5% (3)

222D, 222N

0% (0)

0% (0)

4.2% (1)

222D, 222V, 222A

0% (0)

0% (0)

4.2% (1)

All 222 variants

0% (0)

15.4% (4)

41.8% (10)

  1. Clinical outcome based on patient information, assigned into categories by a medical specialist according to WHO guidance criteria.