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Figure 2 | Virology Journal

Figure 2

From: Adaptive evolution of bat dipeptidyl peptidase 4 (dpp4): implications for the origin and emergence of Middle East respiratory syndrome coronavirus

Figure 2

Interaction of bat DPP4 and MERS-CoV spike protein receptor-binding domain and the location of positively selected sites. The structure was displayed using PyMol v1.6 (http://www.pymol.org/). (A) Homology model showing the structural interactions between bat DPP4 (from common pipistrelle) coloured grey and MERS-CoV spike protein receptor-binding domain coloured blue. The three positively selected residues (positions 187, 288 and 392) located within the interface where the virus-host interact are highlighted as red. (B) Protein alignment of human DPP4 compared to that of seven bat species showing RBD spanning codons 41 – 400. Conserved and variable positions are shown in black and grey text, respectively, and residues under positive selection are coloured red.

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Virology Journal

ISSN: 1743-422X