Genome segment* | Molecular size (bp)** | 5′UTR (bp)** | 3′UTR (bp)** | Protein name*** | Protein size (aa) & mass (kDa)1 | pI value | Predicted function |
---|---|---|---|---|---|---|---|
L1 | 3911 | 18 | 44 | Core shell (T = 1) [λ1] | 1282, 141.41 kDa | 5.47 | major inner capsid protein, Helicase, RNA triphosphatase |
L2 | 3935 | 18 | 44 | Core turret [λ2] | 1290, 143.75 kDa | 4.81 | core spike, guanylyl transferase |
L3 | 3916 | 7 | 48 | Core RdRp [λ3] | 1286, 144.24 kDa | 8.68 | minor inner capsid protein, RNA polymerase |
M1 | 2383 | 21 | 79 | Core NTPase [μ2] | 760, 86.09 kDa | 8.23 | minor inner capsid protein, nucleoside triphosphate phosphohydrolase |
M2 | 2179 | 26 | 89 | Outer shell (T = 13) [μ1] | 687, 74.26 kDa | 6.27 | outer capsid protein, membrane penetration, apoptosis |
M3 | 2403 | 83 | 61 | NS factory [μNS] | 752, 83.53 kDa | 5.00 | NS, genome packaging? |
S1 | 1081 | 28 | 60 | Outer clamp [σ3] | 330, 37.08 kDa | 7.43 | major outer capsid protein, dsRNA binding protein, translation control, modulation of cellular interferon, zinc-binding |
NS, p13 [σ1s] | 124, 12.99 kDa | 4.88 | NS, block cell-cycle progression, cytolytic in PRV | ||||
S2 | 1329 | 21 | 45 | Core clamp [σ2] | 420, 45.93 kDa | 9.02 | major inner capsid protein, morphogenesis? |
S3 | 1143 | 28 | 50 | NS RNA [σNS] | 354, 39.07 kDa | 7.76 | NS, genome packaging? |
S4 | 1040 | 38 | 54 | Outer fiber [σ1] | 315, 34.60 kDa | 6.04 | outer capsid protein (virus attachment), cell tropism, pathways of viral spread in-vivo, virulence |