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Table 2 Significantly-regulated HeLa cell proteins after T3D infection

From: HeLa cell response proteome alterations induced by mammalian reovirus T3D infection

      

Run # 1 (H:L)

Run # 2 (L:H)

 

Accession

HGID

Name

Inf / Mock

(±S.E.M.)

# Pep

% Cov

Z-Score

# Pep

% Cov

Z-score

Cytoplasmic

          

Up-regulated

          

Measured more than once

        
 

gi|222136619

MX1

myxovirus resistance protein 1

9.76

0.52

8

55.9

10.925

23

51.7

7.427

 

gi|94536771

CCD56

coiled-coil domain containing 56

5.48

1.62

5

56.6

0.223

3

20.7

15.154

 

gi|27881482

DDX58

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I

4.76

0.83

3

27.7

7.191

12

23.2

5.203

 

gi|72534658

IFIT3

interferon-induced protein with tetratricopeptide repeats 3

4.65

0.39

4

25.3

7.260

14

46.9

5.067

 

gi|4826774

ISG15

ISG15 ubiquitin-like modifier

4.60

0.51

14

47.3

6.164

14

53.9

5.442

 

gi|116534937

IFIT1

interferon-induced protein with tetratricopeptide repeats 1 isoform 2

3.80

1.36

2

40.4

11.782

8

25.1

3.308

 

gi|156105693

PR285

PPAR-alpha interacting complex protein 285 isoform 1

3.45

1.53

2

22.0

5.564

5

10.6

4.109

 

gi|153082755

IFIT2

interferon-induced protein with tetratricopeptide repeats 2

3.37

0.81

3

33.7

1.291

11

33.1

4.978

 

gi|6274552

STAT1

signal transducer and activator of transcription 1 isoform alpha

3.23

0.39

13

44.4

4.386

34

50.4

4.170

 

gi|45007007

OAS3

2'-5'oligoadenylate synthetase 3

3.00

0.32

4

19.5

4.560

9

17.3

3.761

 

gi|208973246

DHPR

quinoid dihydropteridine reductase

2.40

0.48

2

27.9

0.693

4

20.5

4.171

 

gi|38201706

SAMD9

sterile alpha motif domain containing 9

2.15

0.48

1

18.8

2.560

10

15.4

2.648

 

gi|4506103

E2AK2

eukaryotic translation initiation factor 2-alpha kinase 2

1.97

0.72

3

45.7

2.503

10

16.2

2.374

 

gi|24307901

IFI35

interferon-induced protein 35

1.92

0.44

3

29.2

2.119

5

18.4

2.508

 

gi|166706903

GBP1

guanylate binding protein 1, interferon-inducible, 67 kDa

1.85

0.88

5

25.7

1.682

11

27.2

2.393

 

gi|5031863

LG3BP

galectin 3 binding protein

1.81

0.86

6

19.5

1.731

12

29.2

2.303

 

gi|22035653

APOL2

apolipoprotein L2

1.80

0.53

4

30.3

1.501

6

32.6

2.507

 

gi|27477136

ZCCHV

zinc finger antiviral protein isoform 1

1.80

0.69

2

26.2

2.245

16

25.5

2.007

 

gi|20270303

MIRO2

ras homolog gene family, member T2

1.79

0.92

2

15.7

9.955

6

15.7

−0.055

 

gi|4757876

BST2

bone marrow stromal cell antigen 2

1.68

0.38

5

19.4

1.610

5

18.3

2.201

 

gi|188528628

PNPT1

polyribonucleotide nucleotidyltransferase 1

1.63

0.20

13

47.6

2.221

24

36.8

1.575

Measured once

         
 

gi|156415992

ATP8*

transcription factor B1, mitochondrial

84.09

0.71

   

2

9.2

15.154

 

gi|4557321

APOA1

apolipoprotein A-I preproprotein

7.99

0.97

   

2

23.2

7.089

 

gi|11342664

MX2

myxovirus resistance protein 2

7.72

0.57

   

6

11.3

6.972

 

gi|4502511

CO9

complement component 9 precursor

7.26

4.88

   

2

5.0

6.760

 

gi|166706909

IF44L

interferon-induced protein 44-like

6.18

3.89

   

3

15.9

6.211

 

gi|74229015

OAS1

2',5'-oligoadenylate synthetase 1 isoform 3

5.85

0.86

   

3

11.6

6.024

 

gi|19923717

DTX3L

deltex 3-like

3.68

3.31

   

4

9.7

4.438

 

gi|74229019

OAS2

2'-5'-oligoadenylate synthetase 2 isoform 1

3.50

2.14

   

2

4.9

4.263

 

gi|41350201

EPN1

epsin 1 isoform c

3.20

2.53

   

2

5.5

3.953

 

gi|5174751

YAP1

Yes-associated protein 1, 65 kD

3.12

1.32

   

3

7.9

3.867

 

gi|222831595

DDX60

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

2.92

1.56

   

5

7.6

3.636

 

gi|15208660

RO52

tripartite motif protein 21

2.69

0.63

   

8

22.7

3.364

 

gi|110825982

HERC5

hect domain and RLD 5

2.50

0.86

   

2

4.7

3.104

 

gi|4557499

CTBP2

C-terminal binding protein 2 isoform 1

2.49

1.36

   

7

25.8

3.093

 

gi|4506191

PSMB10

proteasome beta 10 subunit proprotein

2.21

0.71

   

2

7.3

2.688

 

gi|73747915

TAP2

transporter 2, ATP-binding cassette, sub-family B isoform 1

2.16

0.70

   

3

10.8

2.615

 

gi|38016914

SAMH1

SAM domain- and HD domain-containing protein 1

2.16

0.48

   

6

21.7

2.610

 

gi|126012562

LRP1

low density lipoprotein-related protein 1

2.11

0.60

   

3

2.9

2.529

 

gi|4503445

TYPH

endothelial cell growth factor 1 (platelet-derived) precursor

2.10

0.85

   

2

18.1

2.504

 

gi|6912630

IFIT5

interferon-induced protein with tetratricopeptide repeats 5

2.05

0.63

   

3

13.9

2.435

 

gi|112789562

IF16

interferon, gamma-inducible protein 16

1.95

0.64

   

6

21.8

2.263

 

gi|45580709

UN93B

unc-93 homolog B1

1.93

0.77

   

2

4.2

2.231

 

gi|9665248

TAP1

transporter 1, ATP-binding cassette, sub-family B

1.88

0.78

   

2

11.8

2.135

 

gi|52630342

HLA-C

major histocompatibility complex, class I, C precursor

1.80

0.34

   

20

45.4

1.982

Down-regulated

          

Measured more than once

        
 

gi|134288865

S4A7

solute carrier family 4, sodium bicarbonate cotransporter, member 7

0.064

0.21

2

21.7

−3.832

2

3.8

−15.807

 

gi|29294627

PPFIBP1

PTPRF interacting protein binding protein 1 isoform 1

0.30

0.21

3

26.5

−10.860

3

11.0

0.328

 

gi|4506431

RASA1

RAS p21 protein activator 1 isoform 1

0.36

0.06

1

16.5

−1.418

2

1.8

−4.688

 

gi|5453704

PRAF3

ADP-ribosylation-like factor 6 interacting protein 5

0.56

0.18

4

40.4

−3.941

2

29.8

0.235

 

gi|21956645

MTPN

myotrophin

0.56

0.08

9

49.1

−4.823

8

39.0

0.091

Measured once

         
 

gi|167466177

CDC27

cell division cycle protein 27 isoform 1

0.010

0.36

   

2

4.0

−15.807

 

gi|8922549

ASF1B

anti-silencing function 1B

0.33

0.000

   

2

23.8

−3.834

 

gi|33598948

PLCG1

phospholipase C gamma 1 isoform a

0.33

0.34

   

2

6.9

−3.803

 

gi|46049063

XPO6

exportin 6

0.34

0.05

   

2

5.2

−3.706

 

gi|116734706

I2BP2

interferon regulatory factor 2 binding protein 2 isoform B

0.36

0.38

   

3

13.7

−3.517

 

gi|116686114

FERM1

kindlin-1

0.38

0.004

   

3

12.3

−3.348

 

gi|5453543

AK1C1

aldo-keto reductase family 1, member C1

0.39

0.05

14

72.8

−4.099

   
 

gi|63025188

HERC4

hect domain and RLD 4 isoform a

0.41

0.000

   

2

2.5

−3.077

 

gi|14589951

RPAB1

DNA directed RNA polymerase II polypeptide E

0.46

0.14

   

6

21.4

−2.683

 

gi|51317370

NDUA6

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14 kDa

0.47

0.000

   

2

14.9

−2.637

 

gi|10190746

RDH14

retinol dehydrogenase 14 (all-trans and 9-cis)

0.51

0.38

   

2

8.6

−2.306

 

gi|13236559

MMTA2

hypothetical protein LOC79169

0.54

0.01

   

2

35.0

−2.138

 

gi|115430235

UHRF1

ubiquitin-like with PHD and ring finger domains 1 isoform 1

0.55

0.10

   

2

11.1

−2.105

 

gi|71773010

AP1G1

adaptor-related protein complex 1, gamma 1 subunit isoform a

0.55

0.25

4

22.3

−2.570

   

Nuclear

          

Up-regulated

          

Measured more than once

        
 

gi|4826774

ISG15

ISG15 ubiquitin-like modifier

4.05

0.40

5

42.4

4.065

4

23.0

6.275

 

gi|19923236

SP100

nuclear antigen Sp100 isoform 2

2.96

0.93

4

18.1

2.812

8

26.2

4.880

 

gi|112789562

IF16

interferon, gamma-inducible protein 16

2.92

0.40

2

11.8

2.384

6

19.3

4.879

 

gi|67089149

PML

promyelocytic leukemia protein isoform 1

2.34

0.60

2

8.4

2.758

9

21.7

3.496

 

gi|4757876

BST2

bone marrow stromal cell antigen 2

2.03

0.56

3

18.3

2.512

2

13.9

2.290

Measured once

         
 

gi|4503253

DAD1

defender against cell death 1

5.22

0.62

3

17.7

5.110

   
 

gi|188219599

NMI

N-myc and STAT interactor

4.33

1.17

   

2

16.9

6.125

 

gi|24307901

IFI35

interferon-induced protein 35

3.60

0.93

   

3

15.6

5.347

 

gi|4758024

COIL

coilin

2.46

0.83

2

12.8

2.788

   
 

gi|5453690

DNJB1

DnaJ (Hsp40) homolog, subfamily B, member 1

2.32

0.000

   

2

11.8

3.499

 

gi|58530840

DESP

desmoplakin isoform I

2.09

0.91

   

3

9.3

3.054

 

gi|156104878

GLSK

glutaminase

2.03

0.75

   

3

4.8

2.931

 

gi|27477136

ZCCHV

zinc finger antiviral protein isoform 1

1.95

0.74

   

2

2.2

2.754

 

gi|4507951

1433F

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

1.89

1.06

   

2

22.8

2.633

 

gi|5901998

LSM6

Sm protein F

1.85

0.60

   

3

56.3

2.538

 

gi|4506003

PP1A

protein phosphatase 1, catalytic subunit, alpha isoform 1

1.70

0.95

   

4

13.9

2.184

Down-regulated

          

Measured more than once

        
 

gi|55953087

NOG1

G protein-binding protein CRFG

0.10

0.21

2

4.4

−13.385

2

6.3

−1.353

 

gi|4503453

EDF1

endothelial differentiation-related factor 1 isoform alpha

0.63

0.17

4

28.4

−0.672

4

41.2

−2.991

 

gi|4507555

LAP2A

thymopoietin isoform alpha

0.64

0.03

10

15.3

−2.464

10

12.5

−0.479

Measured once

         
 

gi|88853069

VTNC

vitronectin precursor

0.013

0.04

2

4.8

−13.385

   
 

gi|25777615

PSD7

proteasome 26S non-ATPase subunit 7

0.39

0.30

   

3

12.3

−4.046

 

gi|4757732

AIFM1

programmed cell death 8 isoform 1

0.40

0.18

   

2

18.4

−3.870

 

gi|57863257

TCPA

T-complex protein 1 isoform a

0.50

0.04

   

2

5.2

−2.951

 

gi|4506701

RS23

ribosomal protein S23

0.54

0.19

   

4

32.9

−2.647

 

gi|151108473

FIS1

tetratricopeptide repeat domain 11

0.63

0.000

   

2

7.2

−1.990

  1. *: Obsolete record; removed from NCBI database.
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Virology Journal

ISSN: 1743-422X