Articles
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Citation: Virology Journal 2023 20:95
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Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severity
Coronavirus Disease 2019 (COVID-19) is a worldwide pandemic challenge spreading enormously within a few months. COVID-19 is characterized by the over-activation of the immune system causing cytokine storm. Ins...
Citation: Virology Journal 2023 20:94 -
Performance evaluation of in vitro diagnostic kits for hepatitis B virus infection using the regional reference panel of Japan
Hepatitis B virus (HBV) infection is a global public health concern. Precise and sensitive detection of viral markers, including HBV DNA and HBs antigen (Ag), is essential to determine HBV infection.
Citation: Virology Journal 2023 20:93 -
Predictive values of procalcitonin for coinfections in patients with COVID-19: a systematic review and meta-analysis
To assess the ability of procalcitonin (PCT)—a promising marker for coinfections—to predict coinfections in patients with COVID-19.
Citation: Virology Journal 2023 20:92 -
Potential of CRISPR/Cas system as emerging tools in the detection of viral hepatitis infection
Viral hepatitis, the most common cause of inflammatory liver disease, affects hundreds of millions of people worldwide. It is most commonly associated with one of the five nominal hepatitis viruses (hepatitis ...
Citation: Virology Journal 2023 20:91 -
Global mpox lineage discovery and rapid outbreak tracking with nanopore sequencing
Insufficient tracking of virus introduction, spread, and new lineage emergence for the human monkeypox (mpox) virus 1 (hMPXV1) outbreak of 2022 hindered epidemiological studies and public health response. hMPX...
Citation: Virology Journal 2023 20:90 -
Switch from a ritonavir to a cobicistat containing antiretroviral regimen and impact on tacrolimus levels in a kidney transplant recipient
Solid-organ transplantation due to end-stage organ disease is increasingly performed in people living with HIV. Despite improved transplant outcomes, management of these patients remains challenging due to hig...
Citation: Virology Journal 2023 20:89 -
Systematic levels of IL-29 and microRNA185-5p were not associated with severe COVID-19 in the Iranian population
Increased systematic pro-inflammatory cytokines is the main cause of the inflammatory conditions of the hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. In this proj...
Citation: Virology Journal 2023 20:88 -
Pathogenicity and immunogenicity of gI/gE/TK-gene-deleted Felid herpesvirus 1 variants in cats
Felid herpesvirus 1 (FHV-1) is a major pathogenic agent of upper respiratory tract infections and eye damage in felines worldwide. Current FHV-1 vaccines offer limited protection of short duration, and therefore,...
Citation: Virology Journal 2023 20:87 -
Morphological, biological, and genomic characterization of Klebsiella pneumoniae phage vB_Kpn_ZC2
Bacteriophages (phages) are one of the most promising alternatives to traditional antibiotic therapies, especially against multidrug-resistant bacteria. Klebsiella pneumoniae is considered to be an opportunistic ...
Citation: Virology Journal 2023 20:86 -
Differential abundance of IgG antibodies against the spike protein of SARS-CoV-2 and seasonal coronaviruses in patients with fatal COVID-19
Infection with the novel pandemic SARS-CoV-2 virus has been shown to elicit a cross-reactive immune response that could lead to a back-boost of memory recall to previously encountered seasonal (endemic) corona...
Citation: Virology Journal 2023 20:85 -
Water bath is more efficient than hot air oven at thermal inactivation of coronavirus
Thermal inactivation is a conventional and effective method of eliminating the infectivity of pathogens from specimens in clinical and biological laboratories, and reducing the risk of occupational exposure an...
Citation: Virology Journal 2023 20:84 -
Uncovering neglected subtypes and zoonotic transmission of Hepatitis E virus (HEV) in Brazil
Hepatitis E virus (HEV) circulation in humans and swine has been extensively studied in South America over the last two decades. Nevertheless, only 2.1% of reported HEV strains are available as complete genome...
Citation: Virology Journal 2023 20:83 -
The interactions between PML nuclear bodies and small and medium size DNA viruses
Promyelocytic leukemia nuclear bodies (PM NBs), often referred to as membraneless organelles, are dynamic macromolecular protein complexes composed of a PML protein core and other transient or permanent compon...
Citation: Virology Journal 2023 20:82 -
Isolation and characterization of a novel phage belonging to a new genus against Vibrio parahaemolyticus
Vibrio parahaemolyticus is a major foodborne pathogen that contaminates aquatic products and causes great economic losses to aquaculture. Because of the emergence of multidrug-resistant V. parahaemolyticus strain...
Citation: Virology Journal 2023 20:81 -
Peripheral blood lymphocytes influence human papillomavirus infection and clearance: a retrospective cohort study
There is a close correlation between HPV infection and systemic immune status. The purpose of this study was to determine which lymphocytes in peripheral blood influence human papillomavirus (HPV) infection an...
Citation: Virology Journal 2023 20:80 -
Evaluating anti-viral effect of Tylvalosin tartrate on porcine reproductive and respiratory syndrome virus and analyzing the related gene regulation by transcriptomics
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen, characterized by its genetic and antigenic variation. The PRRSV vaccine is widely used, however, the unsatisfi...
Citation: Virology Journal 2023 20:79 -
Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice
Caspases and poly (ADP-ribose) polymerase 1 (PARP1) have been shown to promote influenza A virus (IAV) replication. However, the relative importance and molecular mechanisms of specific caspases and their down...
Citation: Virology Journal 2023 20:78 -
Acalculous cholecystitis is a common extrahepatic manifestation of hepatitis E and suggests a more serious condition
This study aimed to understand the incidence and clinical significance of acalculous cholecystitis in patients with acute hepatitis E (HE).
Citation: Virology Journal 2023 20:77 -
Vaccination with recombinant Lactococcus lactis expressing HA1-IgY Fc fusion protein provides protective mucosal immunity against H9N2 avian influenza virus in chickens
H9N2 virus is mainly transmitted through the respiratory mucosal pathway, so mucosal immunity is considered to play a good role in controlling avian influenza infection. It is commonly accepted that no adequat...
Citation: Virology Journal 2023 20:76 -
MHC class I links with severe pathogenicity in C57BL/6N mice infected with SARS-CoV-2/BMA8
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes non-symptomatic infection, mild influenza-like symptoms to pneumonia, severe acute respiratory distress syndrome, and even death, reflect...
Citation: Virology Journal 2023 20:75 -
Molecular characterization of coxsackievirus B5 from the sputum of pneumonia children patients of Kunming, Southwest China
CVB5 can cause respiratory infections. However, the molecular epidemiological information about CVB5 in respiratory tract samples is still limited. Here, we report five cases in which CVB5 was detected in sput...
Citation: Virology Journal 2023 20:74 -
The interplay between human papillomavirus and vaginal microbiota in cervical cancer development
Over the past few decades, we have grown accustomed to the idea that human papillomavirus can cause tumors. The genetic and environmental factors that make the difference between elimination of viral infection...
Citation: Virology Journal 2023 20:73 -
MRF: a tool to overcome the barrier of inconsistent genome annotations and perform comparative genomics studies for the largest animal DNA virus
The genome of the largest known animal virus, the white spot syndrome virus (WSSV) responsible for huge economic losses and loss of employment in aquaculture, suffers from inconsistent annotation nomenclature....
Citation: Virology Journal 2023 20:72 -
Genomic characterization of an Omono River virus isolated from Culex tritaeniorhynchus in eastern China
Omono River virus (OMRV) is a newly reported, unclassified RNA virus in the family Totiviridae, which infects mosquitoes and bats. In this study, we report the isolation of an OMRV strain SD76 from Culex tritaeni...
Citation: Virology Journal 2023 20:71 -
Comparison of 14 respiratory pathogens among hospitalized children during and after the COVID-19 outbreak in Chaoshan area
Since January 2020, measures has been adopted in the Chaoshan area to limit the spread of COVID-19. Restrictions were removed after August 2020. At the same time, children returned to school. We previously rep...
Citation: Virology Journal 2023 20:70 -
Cutavirus on the skin in an Asian cohort: identification of a novel geographically related genotype
Cutavirus (CuV) is the newest human parvovirus and is currently receiving increasing attention because of its possible association with cutaneous T-cell lymphoma. Despite the pathogenetic potential of CuV, it ...
Citation: Virology Journal 2023 20:69 -
Genetic variants of Dabie bandavirus: classification and biological/clinical implications
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by Dabie bandavirus (DBV), a novel Bandavirus in the family Phenuiviridae. The first case of SFTS was reported in China,...
Citation: Virology Journal 2023 20:68 -
Influenza vaccine effectiveness in patients hospitalized with severe acute respiratory infection in Lithuania during the 2019–2020 influenza season: a test negative case – control study
Influenza is a contagious viral airborne disease that adds to the clinical and economic burden on the healthcare system. It could be prevented substantially by seasonal influenza vaccination. Seasonal influenz...
Citation: Virology Journal 2023 20:67 -
Screening and identification of cyprinid herpesvirus 2 (CyHV-2) ORF55-interacting proteins by phage display
Cyprinid herpesvirus 2 (CyHV-2) is a pathogenic fish virus belonging to family Alloherpesviridae. The CyHV-2 gene encoding thymidine kinase (TK) is an important virulence-associated factor. Therefore, we aimed...
Citation: Virology Journal 2023 20:66 -
SARS-CoV-2 infection aggravates cigarette smoke-exposed cell damage in primary human airway epithelia
The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a worldwide pandemic with over 627 million cases and over 6.5 million deaths...
Citation: Virology Journal 2023 20:65 -
Revolutionizing viral disease vaccination: the promising clinical advancements of non-replicating mRNA vaccines
The mRNA vaccine technology was developed rapidly during the global pandemic of COVID-19. The crucial role of the COVID-19 mRNA vaccine in preventing viral infection also have been beneficial to the exploratio...
Citation: Virology Journal 2023 20:64 -
An optimized circular polymerase extension reaction-based method for functional analysis of SARS-CoV-2
Reverse genetics systems have been crucial for studying specific viral genes and their relevance in the virus lifecycle, and become important tools for the rational attenuation of viruses and thereby for vacci...
Citation: Virology Journal 2023 20:63 -
Development and application of a dual ERA method for the detection of Feline Calicivirus and Feline Herpesvirus Type I
Feline calicivirus (FCV) and feline herpesvirus type I (FHV-1) are the most common viral pathogens responsible for cat respiratory diseases, and coinfection with these two pathogens is often found. In veterina...
Citation: Virology Journal 2023 20:62 -
Progress in the study of parvovirus entry pathway
A group of DNA viruses called parvoviruses that have significant effects on cancer therapy and genetic engineering applications. After passing through the cell membrane to reach the cytosol, it moves along the...
Citation: Virology Journal 2023 20:61 -
Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants
Norovirus is a leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the norovirus O...
Citation: Virology Journal 2023 20:60 -
A comparison of transmissibility of SARS-CoV-2 variants of concern
The World Health Organization (WHO) has currently detected five Variants of Concern of SARS-CoV-2 having the WHO labels of ‘Alpha’, ‘Beta’, ‘Gamma’, ‘Delta’ and ‘Omicron’. We aimed to assess and compare the tr...
Citation: Virology Journal 2023 20:59 -
ARIH1 inhibits influenza A virus replication and facilitates RIG-I dependent immune signaling by interacting with SQSTM1/p62
Multiple host factors are involved in modulating type I interferon expression induced by viruses; however, the mechanism is not fully elucidated. Influenza A virus infection causes severe respiratory symptoms ...
Citation: Virology Journal 2023 20:58 -
Evaluation of ten (10) SARS-CoV-2 rapid serological tests in comparison with WANTAI SARS-CoV-2 ab ELISA in Burkina Faso, West Africa
The aim of this study was to evaluate the performance of ten (10) SARS-CoV-2 serological rapid diagnostic tests in comparison with the WANTAI SARS-CoV-2 Ab ELISA test in a laboratory setting.
Citation: Virology Journal 2023 20:57 -
SARS-CoV2 mutations and impact on mortality: observational study in a sub-saharan Africa hospital
One year after the coronavirus disease 2019 (COVID-19) pandemic, the focus of attention has shifted to the emergence and spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of conce...
Citation: Virology Journal 2023 20:56 -
SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
When viruses like SARS-CoV-2 infect cells, they reprogram the repertoire of cellular and viral transcripts that are being translated to optimize their strategy of replication, often targeting host translation ...
Citation: Virology Journal 2023 20:55 -
Proteins in pregnant swine serum promote the African swine fever virus replication: an iTRAQ-based quantitative proteomic analysis
African swine fever (ASF) is a severe infectious disease caused by the African swine fever virus (ASFV), seriously endangering the global pig industry. ASFV possesses a large genome, strong mutation ability, a...
Citation: Virology Journal 2023 20:54 -
Simple prediction of COVID-19 convalescent plasma units with high levels of neutralization antibodies
Hyperimmune convalescent COVID-19 plasma (CCP) containing anti-SARS-CoV-2 neutralizing antibodies (NAbs) was proposed as a therapeutic option for patients early in the new coronavirus disease pandemic. The eff...
Citation: Virology Journal 2023 20:53 -
Comparison of gut viral communities in children under 5 years old and newborns
The gut virome of humans is mainly composed of bacteriophages and their role in shaping the gut microbiome and influencing human health is increasingly recognized. However, little is known about the dynamic ch...
Citation: Virology Journal 2023 20:52 -
Inducible nitric oxide synthase deficiency promotes murine-β-coronavirus induced demyelination
Multiple sclerosis (MS) is characterized by neuroinflammation and demyelination orchestrated by activated neuroglial cells, CNS infiltrating leukocytes, and their reciprocal interactions through inflammatory s...
Citation: Virology Journal 2023 20:51 -
Anti-human immunodeficiency virus-1 activity of MoMo30 protein isolated from the traditional African medicinal plant Momordica balsamina
Plants are used in traditional healing practices of many cultures worldwide. Momordica balsamina is a plant commonly used by traditional African healers as a part of a treatment for HIV/AIDS. It is typically give...
Citation: Virology Journal 2023 20:50 -
The persistence and stabilization of auxiliary genes in the human skin virome
The human skin contains a diverse microbiome that provides protective functions against environmental pathogens. Studies have demonstrated that bacteriophages modulate bacterial community composition and facil...
Citation: Virology Journal 2023 20:49 -
Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library
Here, using viral metagenomic method, a novel whale papillomavirus (temporarily named wPV, GenBank accession number OP856597) was discovered in a whale (Delphinapterus leucas) pharyngeal metagenomic library. The ...
Citation: Virology Journal 2023 20:48 -
Evaluation of the clinical efficacy of vaginal treatment options for persistent high-risk human papillomavirus infection after excisional treatment of cervical high-grade squamous intraepithelial lesions: a systematic review and Bayesian network meta-analysis
To evaluate the clinical efficacy of different vaginal administration on cervical persistent high-risk human papillomavirus (HR-HPV) infection after excisional treatment for high-grade squamous intraepithelial...
Citation: Virology Journal 2023 20:47 -
Virome of wild rats (Rattus norvegicus) captured far from pig farms in Jiangsu province of China reveals novel porcine circovirus type 2d (PCV2d) sequences
Porcine circovirus type 2 (PCV2) has caused great economic losses in the global pig industry. There have been published records of wild rats acting as the reservoirs of PCV2 (only PCV2a and PCV2b), but almost ...
Citation: Virology Journal 2023 20:46