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Positive-strand RNA viruses

Section Editor: Jason Mackenzie, The University of Melbourne, Australia
Deputy Section Editor: Rushika Perera, Colorado State University, USA

The Positive-strand RNA viruses section of Virology Journal invites submissions of research articles and reviews covering all aspects of positive-strand RNA virus biology. Basic research topics of interest include all facets of the viral life cycle from viral attachment and entry, viral RNA replication and translation, viral gene expression/regulation, viral protein processing, viral particle assembly and secretion. We welcome studies that investigate interactions between the virus and host that impact viral replication and the cellular response to infection. Other topics include but are not limited to viral pathogenesis, epidemiology, and viral immunology. We also welcome basic and translational studies on the development of novel model systems, antiviral drugs and vaccines.

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  1. Porcine Reproductive and Respiratory Syndrome (PRRS) is a disease of major economic impact worldwide. The etiologic agent of this disease is the PRRS virus (PRRSV). Increasing evidence suggest that microevolut...

    Authors: Zen H Lu, Alexander Brown, Alison D Wilson, Jay G Calvert, Monica Balasch, Pablo Fuentes-Utrilla, Julia Loecherbach, Frances Turner, Richard Talbot, Alan L Archibald and Tahar Ait-Ali
    Citation: Virology Journal 2014 11:42
  2. Human Rhinoviruses (HRV) are major causative agents of acute respiratory tract infections in all age group and important contributing factors of childhood morbidity and mortality. Clinical presentation is poor...

    Authors: Julien Dupouey, Laetitia Ninove, Vanessa Ferrier, Odile Py, Céline Gazin, Laurence Thirion-Perrier and Xavier de Lamballerie
    Citation: Virology Journal 2014 11:31
  3. Porcine reproductive and respiratory syndrome virus (PRRSV) infection leads to substantial economic losses to the swine industry worldwide. However, no effective countermeasures exist to combat this virus infe...

    Authors: Jintao Gao, Shuqi Xiao, Xiaohong Liu, Liangliang Wang, Xiaoyu Zhang, Qianqian Ji, Yue Wang, Delin Mo and Yaosheng Chen
    Citation: Virology Journal 2014 11:17
  4. Japanese encephalitis virus (JEV) has a significant impact on public health. An estimated three billion people in 'at-risk’ regions remain unvaccinated and the number of unvaccinated individuals in certain Asi...

    Authors: Zixue Shi, Jianchao Wei, Xufang Deng, Shuqing Li, Yafeng Qiu, Donghua Shao, Beibei Li, Keyu Zhang, Feiqun Xue, Xiaodu Wang and Zhiyong Ma
    Citation: Virology Journal 2014 11:10
  5. Flavivirus NS1 is a non-structural glycoprotein that is expressed on the cell surface and secreted into the extracellular space, where it acts as an antagonist of complement pathway activation. Despite its tra...

    Authors: Soonjeon Youn, Rebecca L Ambrose, Jason M Mackenzie and Michael S Diamond
    Citation: Virology Journal 2013 10:339
  6. Norovirus is the commonest cause of epidemic gastroenteritis among people of all ages. Outbreaks frequently occur in hospitals and the community, costing the UK an estimated £110 m per annum. An evolutionary e...

    Authors: T H Nicholas Wong, Bethany L Dearlove, Jessica Hedge, Adam P Giess, Paolo Piazza, Amy Trebes, John Paul, Erasmus Smit, E Grace Smith, Julian K Sutton, Mark H Wilcox, Kate E Dingle, Tim E A Peto, Derrick W Crook, Daniel J Wilson and David H Wyllie
    Citation: Virology Journal 2013 10:335
  7. Classical swine fever (CSF) caused by CSF virus (CSFV) is a highly contagious disease of pigs. The RNA helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5) ar...

    Authors: Xiao-Ying Dong, Wen-Jun Liu, Ming-Qiu Zhao, Jia-Ying Wang, Jing-Jing Pei, Yong-Wen Luo, Chun-Mei Ju and Jin-Ding Chen
    Citation: Virology Journal 2013 10:286
  8. In recent decades, Echovirus 30 (E30) and Japanese encephalitis virus (JEV) have been reported to be the common causative agents of acute meningitis among patients in South East Asia. An E30 outbreak in Vietna...

    Authors: Yuki Takamatsu, Leo Uchida, Phan Thi Nga, Kenta Okamoto, Takeshi Nabeshima, Dang Thi Thu Thao, Do Thien Hai, Nguyen Thi Tuyet, Hoang Minh Duc, Le Xuan Luat, Futoshi Hasebe and Kouichi Morita
    Citation: Virology Journal 2013 10:280
  9. Chikungunya virus (CHIKV) is an alphavirus of the Togaviridae family. After autoproteolytic cleavage, the CHIKV capsid protein (CP) is involved in RNA binding and assembly of the viral particle. The monomeric CP ...

    Authors: Saijo Thomas, Jagdish Rai, Lijo John, Stephan Schaefer, Brigitte M Pützer and Ottmar Herchenröder
    Citation: Virology Journal 2013 10:269
  10. The clinical presentation of dengue is classified by the World Health Organization into dengue without warning signs, dengue with warning signs and severe dengue. Reports of neurological disease caused by Dengue ...

    Authors: Kátia Paulino Ribeiro de Souza, Emanuele Guimarães Silva, Eliseu Soares de Oliveira Rocha, Leandra Barcelos Figueiredo, Camila Megale de Almeida-Leite, Rosa Maria Esteves Arantes, Juliana de Assis Silva Gomes, Gustavo Portela Ferreira, Jaquelline Germano de Oliveira, Erna Geessien Kroon and Marco Antônio Campos
    Citation: Virology Journal 2013 10:267
  11. Evaluation of the primary etiologic agents that cause aseptic meningitis outbreaks may provide valuable information regarding the prevention and management of aseptic meningitis. An outbreak of aseptic meningi...

    Authors: Hong Xiao, Dawei Guan, Ruiyu Chen, Pingxi Chen, Corina Monagin, Wei Li, Juan Su, Cong Ma, Wanli Zhang and Changwen Ke
    Citation: Virology Journal 2013 10:263
  12. Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute viral encephalitis in humans. Pigs are important amplifiers of JEV. The entry mechanism of JEV into porcine cells remains larg...

    Authors: Songbai Yang, Minhui He, Xiangdong Liu, Xinyun Li, Bin Fan and Shuhong Zhao
    Citation: Virology Journal 2013 10:258
  13. Several studies have shown that American genotype dengue 2 viruses (DENV2) have reduced viral fitness in the mosquito vector, Aedes aegypti, compared to other DENV2 genotypes. Diminished replication efficiency or...

    Authors: Cynthia CH Khoo, Jeffrey B Doty, Nicole L Held, Ken E Olson and Alexander WE Franz
    Citation: Virology Journal 2013 10:257
  14. Ophiostoma novo-ulmi is the causative agent of Dutch elm disease (DED). It is an ascomycetous filamentous fungus that ranks as the third most devastating fungal pathogen in Canada. The disease front has spread ea...

    Authors: William E Hintz, Joyce S Carneiro, Irina Kassatenko, Aniko Varga and Delano James
    Citation: Virology Journal 2013 10:252
  15. The flaviviral nonstructural protein 5 (NS5) is a phosphoprotein, though the precise identities and roles of many specific phosphorylations remain unknown. Protein kinase G (PKG), a cGMP-dependent protein kina...

    Authors: Julie A Keating, Dipankar Bhattacharya, Pei-Yin Lim, Shaun Falk, Bernard Weisblum, Kristen A Bernard, Mayuri Sharma, Richard J Kuhn and Rob Striker
    Citation: Virology Journal 2013 10:242
  16. Chikungunya virus (CHIKV) has been responsible for large epidemic outbreaks causing fever, headache, rash and severe arthralgia. So far, no specific treatment or vaccine is available. As nucleic acid amplifica...

    Authors: Sabine Gläsker, Aleksei Lulla, Valeria Lulla, Therese Couderc, Jan Felix Drexler, Peter Liljeström, Marc Lecuit, Christian Drosten, Andres Merits and Beate Mareike Kümmerer
    Citation: Virology Journal 2013 10:235
  17. Cryopreserved primary human renal proximal tubule epithelial cells (RPTEC) were obtained from a commercial supplier for studies of Simian virus 40 (SV40). Within twelve hrs after cell cultures were initiated, cyt...

    Authors: John A Lednicky, Thomas B Waltzek, Elizabeth McGeehan, Julia C Loeb, Sara B Hamilton and Maya C Luetke
    Citation: Virology Journal 2013 10:213