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Negative-strand RNA viruses

Section Editor: Bert Rima, Queen’s University Belfast, UK
Deputy Section Editor: John Barr, University of Leeds, UK ​​​​​​​

The Negative-strand RNA viruses section of Virology Journal aims to publish research articles and reviews covering all aspects of segmented and non-segmented negative strand RNA viruses from all eukaryotes. Basic research topics of interest include aspects of the viral life cycle: viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress as wells as virus-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants. We also welcome basic and translational studies on the development of antiviral drugs and vaccines. Interdisciplinary research on these viruses using multiple approaches is particularly welcome.

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  1. Content type: Research

    Respiratory Syncytial Virus (RSV) is an important human respiratory pathogen, particularly of infants and older adults, and despite several decades of research and development, no licensed vaccine is available...

    Authors: Bing Hu, Jiawei Jiang, Jianbo Zhan, Guoming Li, Yongzhong Jiang, Xuhua Guan, Yuanding Chen and Zhizheng Fang

    Citation: Virology Journal 2014 11:142

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  2. Content type: Research

    Although national surveillance programs are in place to monitor norovirus epidemiology, the emergence of new strains and the genetic diversity among genotypes can be challenging for clinical laboratories. This...

    Authors: Brenda-Lee Rooney, Janice Pettipas, Elsie Grudeski, Oksana Mykytczuk, Xiao-Li Pang, Tim F Booth, Todd F Hatchette and Jason J LeBlanc

    Citation: Virology Journal 2014 11:129

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  3. Content type: Research

    Arenavirus Junin is the causative agent of Argentine hemorrhagic fever. Limited information is available concerning the pathogenesis of this human disease, especially the pathogenesis of acute and late neurolo...

    Authors: Olga A Kolokoltsova, Nadezhda E Yun and Slobodan Paessler

    Citation: Virology Journal 2014 11:126

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  4. Content type: Research

    Hantaviruses are causative agents of hemorrhagic fever with renal syndrome (HFRS) and nephropathia epidemica (NE) in the Old World and hantavirus pulmonary syndrome (HPS) in the New World. There is a need for ...

    Authors: Takako Amada, Kumiko Yoshimatsu, Takaaki Koma, Kenta Shimizu, Chandika D Gamage, Kanae Shiokawa, Sanae Nishio, Clas Ahlm and Jiro Arikawa

    Citation: Virology Journal 2014 11:87

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  5. Content type: Research

    Rabies virus is the causative agent of rabies, a central nervous system disease that is almost invariably fatal. Currently vaccination is the most effective strategy for preventing rabies, and vaccines are mos...

    Authors: Caiping Guo, Chunhua Wang, Shan Luo, Shimao Zhu, Hui Li, Yongdi Liu, Lanzhen Zhou, Pei Zhang, Xin Zhang, Yujiang Ding, Weirong Huang, Kaiyong Wu, Yanpeng Zhang, Weihua Rong and Hua Tian

    Citation: Virology Journal 2014 11:85

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  6. Content type: Case Report

    Human rabies infection continues to be a significant public health burden globally, and is occasionally imported to high income settings where the Milwaukee Protocol for intensive care management has recently ...

    Authors: Smriti Pathak, Daniel L Horton, Sebastian Lucas, David Brown, Shumonta Quaderi, Sara Polhill, David Walker, Eleni Nastouli, Alejandro Núñez, Emma L Wise, Anthony R Fooks and Michael Brown

    Citation: Virology Journal 2014 11:63

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  7. Content type: Research

    Respiratory syncytial virus (RSV) is the main cause of lower respiratory tract illness in children worldwide. Molecular analyses show two distinct RSV groups (A and B) that comprise different genotypes. This v...

    Authors: Fernanda de-Paris, Caroline Beck, Luciana de Souza Nunes, Alice Mombach Pinheiro, Rodrigo Minuto Paiva, Denise da Silva Menezes, Márcia Rosane Pires, Rodrigo Pires dos Santos, Ricardo de Souza Kuchenbecker and Afonso Luis Barth

    Citation: Virology Journal 2014 11:36

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  8. Content type: Research

    In recent years, the reported infection cases by coxsackievirus (CV) have been on the rise. In order to reveal the relationship between the nucleotide and amino acid sequences and the viral virulence of the CV...

    Authors: Bin Liu, Zhe Li, Fengyang Xiang, Fan Li, Yang Zheng and Guoqing Wang

    Citation: Virology Journal 2014 11:33

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  9. Content type: Research

    Using a murine model of parainfluenza virus infection (mPIV1 or Sendai virus; SeV), we compared the inflammatory responses to lethal and sub-lethal infections in inbred DBA/2 mice.

    Authors: Manika Suryadevara, Cynthia A Bonville, Helene F Rosenberg and Joseph B Domachowske

    Citation: Virology Journal 2013 10:357

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  10. Content type: Research

    Using reverse genetics, we generated a recombinant low-pathogenic LaSota strain Newcastle disease virus (NDV) expressing the glycoprotein (GP) of Ebola virus (EBOV), designated rLa-EBOVGP, and evaluated its bi...

    Authors: Zhiyuan Wen, Bolin Zhao, Kun Song, Xule Hu, Weiye Chen, Dongni Kong, Jinying Ge and Zhigao Bu

    Citation: Virology Journal 2013 10:331

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  11. Content type: Research

    Human respiratory syncytial virus (hRSV) is a leading cause of severe lower respiratory infection and a major public health threat worldwide. To date, no vaccine or effective therapeutic agent has been develop...

    Authors: Han-Bo Shin, Myung-Soo Choi, Byeol Ryu, Na-Rae Lee, Hye-In Kim, Hye-Eun Choi, Jun Chang, Kyung-Tae Lee, Dae Sik Jang and Kyung-Soo Inn

    Citation: Virology Journal 2013 10:303

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  12. Content type: Research

    Hantaviruses cause acute hemorrhagic fever with renal syndrome (HFRS). Currently, several types of inactivated HFRS vaccines are widely used, however the limited ability of these immunogen to elicit neutralizi...

    Authors: Lan Yu, Wentao Bai, Xingan Wu, Liang Zhang, Lei Zhang, Puyuan Li, Fang Wang, Ziyu Liu, Fanglin Zhang and Zhikai Xu

    Citation: Virology Journal 2013 10:301

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  13. Content type: Research

    Human metapneumovirus (HMPV) is now a major cause of lower respiratory infection in children. Although primary isolation of HMPV has been achieved in several different cell lines, the low level of virus replic...

    Authors: Liat Hui Loo, Muhammad Raihan Jumat, Yi Fu, Teck Choon Ayi, Pui San Wong, Nancy WS Tee, Boon Huan Tan and Richard J Sugrue

    Citation: Virology Journal 2013 10:294

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  14. Content type: Research

    Newcastle disease virus (NDV) is the causative agent of the Newcastle disease, a severe disease in birds associated with substantial economic losses to the poultry industry worldwide. Sweden is situated along ...

    Authors: Conny Tolf, Michelle Wille, Ann-Katrin Haidar, Alexis Avril, Siamak Zohari and Jonas Waldenström

    Citation: Virology Journal 2013 10:285

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  15. Content type: Research

    During 2009/10 a major measles epidemic caused by genotype B3 occurred in South Africa. Measles inclusion body encephalitis (MIBE) was diagnosed in a number of highly immuno-compromised HIV patients. The diagn...

    Authors: Diana R Hardie, Christine Albertyn, Jeannine M Heckmann and Heidi EM Smuts

    Citation: Virology Journal 2013 10:283

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  16. Content type: Research

    Tacaribe virus (TCRV) is a less biohazardous relative of the highly pathogenic clade B New World arenaviruses that cause viral hemorrhagic fever syndromes and require handling in maximum containment facilities...

    Authors: Eric J Sefing, Min-Hui Wong, Deanna P Larson, Brett L Hurst, Arnaud J Van Wettere, Stewart W Schneller and Brian B Gowen

    Citation: Virology Journal 2013 10:221

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  17. Content type: Research

    Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA.

    Authors: Gustavo Palacios, Naomi L Forrester, Nazir Savji, Amelia P A Travassos da Rosa, Hilda Guzman, Kelly DeToy, Vsevolod L Popov, Peter J Walker, W Ian Lipkin, Nikos Vasilakis and Robert B Tesh

    Citation: Virology Journal 2013 10:219

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  18. Content type: Methodology

    Few studies have used quantitative polymerase chain reaction (qPCR) as an approach to measure virus neutralization assay endpoints. Its lack of use may not be surprising considering that sample nucleic acid ex...

    Authors: Jan C Varada, Belete Teferedegne, R Lynne Crim, Thembi Mdluli, Susette Audet, Keith Peden, Judy Beeler and Haruhiko Murata

    Citation: Virology Journal 2013 10:195

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  19. Content type: Research

    Newcastle disease (ND) is one of the most deadly diseases of poultry around the globe. The disease is endemic in Pakistan and recurrent outbreaks are being reported regularly in wild captive, rural and commerc...

    Authors: Muhammad Zubair Shabbir, Siamak Zohari, Tahir Yaqub, Jawad Nazir, Muhammad Abu Bakr Shabbir, Nadia Mukhtar, Muhammad Shafee, Muhammad Sajid, Muhammad Anees, Muhammad Abbas, Muhammad Tanveer Khan, Asad Amanat Ali, Aamir Ghafoor, Abdul Ahad, Aijaz Ali Channa, Aftab Ahmad Anjum…

    Citation: Virology Journal 2013 10:170

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