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Negative-strand RNA viruses

Section Editor: Bert Rima, Queen’s University Belfast, UK
Deputy Section Editor: John Barr, University of Leeds, UK ​​​​​​​

The Negative-strand RNA viruses section of Virology Journal aims to publish research articles and reviews covering all aspects of segmented and non-segmented negative strand RNA viruses from all eukaryotes. Basic research topics of interest include aspects of the viral life cycle: viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress as wells as virus-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants. We also welcome basic and translational studies on the development of antiviral drugs and vaccines. Interdisciplinary research on these viruses using multiple approaches is particularly welcome.

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  1. Human respiratory syncytial virus (HRSV) is a leading viral etiologic agent of pediatric lower respiratory infections, including bronchiolitis and pneumonia. Two antigenic subgroups, HRSV-A and B, each contain...

    Authors: Francois Marie Ngako Kadji, Michiko Okamoto, Yuki Furuse, Raita Tamaki, Akira Suzuki, Irene Lirio, Clyde Dapat, Rungnapa Malasao, Mariko Saito, Gay Anne Granada Pedrera-Rico, Veronica Tallo, Socorro Lupisan, Mayuko Saito and Hitoshi Oshitani
    Citation: Virology Journal 2016 13:113
  2. Research with high biocontainment pathogens such as Rift Valley fever virus (RVFV) and Lassa virus (LASV) is expensive, potentially hazardous, and limited to select institutions. Surrogate pathogens such as Pu...

    Authors: Christopher P. Stefan, Kitty Chase, Susan Coyne, David A. Kulesh, Timothy D. Minogue and Jeffrey W. Koehler
    Citation: Virology Journal 2016 13:54
  3. Respiratory syncytial virus (RSV) can cause recurrent and severe respiratory tract infections. Cytoskeletal proteins are often involved during viral infections, either for cell entry or the initiation of the i...

    Authors: Jop Jans, Hicham elMoussaoui, Ronald de Groot, Marien I. de Jonge and Gerben Ferwerda
    Citation: Virology Journal 2016 13:52
  4. Vesicular stomatitis virus (VSV) causes severe losses to the animal husbandry industry. In this study, a recombinant Newcastle disease virus (NDV) expressing the glycoprotein (G) of VSV (rL-VSV-G) was construc...

    Authors: Minmin Zhang, Jinying Ge, Xiaofang Li, Weiye Chen, Xijun Wang, Zhiyuan Wen and Zhigao Bu
    Citation: Virology Journal 2016 13:31
  5. Rodents are natural reservoirs of hantaviruses, which cause two disease types: hemorrhagic fever with renal syndrome in Eurasia and hantavirus pulmonary syndrome in North America. Hantaviruses related human ca...

    Authors: Xing-Yi Ge, Wei-Hong Yang, Hong Pan, Ji-Hua Zhou, Xi Han, Guang-Jian Zhu, James S. Desmond, Peter Daszak, Zheng-Li Shi and Yun-Zhi Zhang
    Citation: Virology Journal 2016 13:27

    The Erratum to this article has been published in Virology Journal 2016 13:75

  6. During respiratory syncytial virus (RSV) infection filamentous virus particles are formed on the cell surface. Although the virus infectivity remains cell-associated, low levels of cell-free virus is detected ...

    Authors: Tra Nguyen Huong, Laxmi Iyer Ravi, Boon Huan Tan and Richard J. Sugrue
    Citation: Virology Journal 2016 13:12
  7. Mumps virus is a negative-sense, single stranded RNA virus consisting of a ribonucleocapsid core enveloped by a lipid membrane derived from host cell, which causes mumps disease preventable by vaccination. Sin...

    Authors: Marija Brgles, Maximilian Bonta, Maja Šantak, Maja Jagušić, Dubravko Forčić, Beata Halassy, Günter Allmaier and Martina Marchetti-Deschmann
    Citation: Virology Journal 2016 13:9
  8. The strains of the genotype VIId Newcastle disease virus (NDV) induce more severe tissue damage in lymphoid organs than other virulent strains. The underlying molecular mechanisms are poorly understood.

    Authors: Yan Kai, Zenglei Hu, Haixu Xu, Shunlin Hu, Jie Zhu, Jiao Hu, Xiaoquan Wang, Xiaowen Liu and Xiufan Liu
    Citation: Virology Journal 2015 12:133
  9. The strains of Newcastle disease virus (NDV) can be divided into two distinct clades: class I and class II. At present, limited molecular epidemiological data are available for the class I virus at live bird m...

    Authors: Jie Zhu, Haixu Xu, Jingjing Liu, Zhenzhen Zhao, Shunlin Hu, Xiaoquan Wang and Xiufan Liu
    Citation: Virology Journal 2014 11:211
  10. In the frame of active lyssavirus surveillance in bats, oropharyngeal swabs from German (N = 2297) and Danish (N = 134) insectivorous bats were investigated using a newly developed generic pan-lyssavirus real-...

    Authors: Melina Fischer, Conrad M Freuling, Thomas Müller, Juliane Schatz, Thomas Bruun Rasmussen, Mariann Chriel, Anne Balkema-Buschmann, Martin Beer and Bernd Hoffmann
    Citation: Virology Journal 2014 11:196
  11. Avian bornaviruses (ABV) are a recently described group of intranuclear negative-stranded RNA viruses (Order Mononegavirales, Family Bornaviridae). At least 13 different ABV genotypes have been described. One gen...

    Authors: Jianhua Guo, H L Shivaprasad, Raquel R Rech, Jill J Heatley, Ian Tizard and Susan Payne
    Citation: Virology Journal 2014 11:197
  12. There are no approved small molecule drug therapies for human respiratory syncytial virus (hRSV), a cause of morbidity and mortality in at-risk newborns, the immunocompromised, and the elderly. We have investi...

    Authors: Adam B Shapiro, Ning Gao, Nichole O’Connell, Jun Hu, Jason Thresher, Rong-Fang Gu, Ross Overman, Ian M Hardern and Graham G Sproat
    Citation: Virology Journal 2014 11:191
  13. Protection against infection by Newcastle disease virus (NDV), also designated as avian paramyxovirus subtype-1 (APMV-1), is mediated by immune responses to the two surface glycoproteins, hemagglutinin-neurami...

    Authors: Christian Grund, Constanze Steglich, Eva Huthmann, Martin Beer, Thomas C Mettenleiter and Angela Römer-Oberdörfer
    Citation: Virology Journal 2014 11:179
  14. Rabies virus is the main etiologic agent of the widespread neurological disease rabies. Recently, the China rabies virus vaccine strain CTN-1 adapted to chicken embryo cells, which has been designated as CTNCE...

    Authors: Shimao Zhu, Chunhua Wang, Pei Zhang, Hui Li, Shan Luo and Caiping Guo
    Citation: Virology Journal 2014 11:176
  15. The influenza RNA dependent RNA polymerase synthesizes viral RNA in the nucleus as functional viral ribonucleoprotein (vRNP) complexes with RNA and nucleoprotein (NP). The N-terminus of NP contains an unconven...

    Authors: Abel Sanchez, Christian F Guerrero-Juarez, Jose Ramirez and Laura L Newcomb
    Citation: Virology Journal 2014 11:155
  16. Newcastle disease (ND) is an OIE listed disease caused by virulent avian paramyxovirus type 1 (APMV-1) strains, which is enzootic and causes large economic losses in the poultry sector. Genotype VII and genoty...

    Authors: Yinfeng Kang, Yanling Li, Runyu Yuan, Xianwei Li, Minhua Sun, Zhaoxiong Wang, Minsha Feng, Peirong Jiao and Tao Ren
    Citation: Virology Journal 2014 11:147
  17. The use of sequence independent methods combined with next generation sequencing for identification purposes in clinical samples appears promising and exciting results have been achieved to understand unexplai...

    Authors: Shahzad Shaukat, Mehar Angez, Muhammad Masroor Alam, Maarten F Jebbink, Martin Deijs, Marta Canuti, Salmaan Sharif, Michel de Vries, Adnan Khurshid, Tariq Mahmood, Lia van der Hoek and SyedSohail Zahoor Zaidi
    Citation: Virology Journal 2014 11:146
  18. Respiratory Syncytial Virus (RSV) is an important human respiratory pathogen, particularly of infants and older adults, and despite several decades of research and development, no licensed vaccine is available...

    Authors: Bing Hu, Jiawei Jiang, Jianbo Zhan, Guoming Li, Yongzhong Jiang, Xuhua Guan, Yuanding Chen and Zhizheng Fang
    Citation: Virology Journal 2014 11:142
  19. Although national surveillance programs are in place to monitor norovirus epidemiology, the emergence of new strains and the genetic diversity among genotypes can be challenging for clinical laboratories. This...

    Authors: Brenda-Lee Rooney, Janice Pettipas, Elsie Grudeski, Oksana Mykytczuk, Xiao-Li Pang, Tim F Booth, Todd F Hatchette and Jason J LeBlanc
    Citation: Virology Journal 2014 11:129
  20. Arenavirus Junin is the causative agent of Argentine hemorrhagic fever. Limited information is available concerning the pathogenesis of this human disease, especially the pathogenesis of acute and late neurolo...

    Authors: Olga A Kolokoltsova, Nadezhda E Yun and Slobodan Paessler
    Citation: Virology Journal 2014 11:126
  21. Hantaviruses are causative agents of hemorrhagic fever with renal syndrome (HFRS) and nephropathia epidemica (NE) in the Old World and hantavirus pulmonary syndrome (HPS) in the New World. There is a need for ...

    Authors: Takako Amada, Kumiko Yoshimatsu, Takaaki Koma, Kenta Shimizu, Chandika D Gamage, Kanae Shiokawa, Sanae Nishio, Clas Ahlm and Jiro Arikawa
    Citation: Virology Journal 2014 11:87
  22. Rabies virus is the causative agent of rabies, a central nervous system disease that is almost invariably fatal. Currently vaccination is the most effective strategy for preventing rabies, and vaccines are mos...

    Authors: Caiping Guo, Chunhua Wang, Shan Luo, Shimao Zhu, Hui Li, Yongdi Liu, Lanzhen Zhou, Pei Zhang, Xin Zhang, Yujiang Ding, Weirong Huang, Kaiyong Wu, Yanpeng Zhang, Weihua Rong and Hua Tian
    Citation: Virology Journal 2014 11:85
  23. Human rabies infection continues to be a significant public health burden globally, and is occasionally imported to high income settings where the Milwaukee Protocol for intensive care management has recently ...

    Authors: Smriti Pathak, Daniel L Horton, Sebastian Lucas, David Brown, Shumonta Quaderi, Sara Polhill, David Walker, Eleni Nastouli, Alejandro Núñez, Emma L Wise, Anthony R Fooks and Michael Brown
    Citation: Virology Journal 2014 11:63
  24. Respiratory syncytial virus (RSV) is the main cause of lower respiratory tract illness in children worldwide. Molecular analyses show two distinct RSV groups (A and B) that comprise different genotypes. This v...

    Authors: Fernanda de-Paris, Caroline Beck, Luciana de Souza Nunes, Alice Mombach Pinheiro, Rodrigo Minuto Paiva, Denise da Silva Menezes, Márcia Rosane Pires, Rodrigo Pires dos Santos, Ricardo de Souza Kuchenbecker and Afonso Luis Barth
    Citation: Virology Journal 2014 11:36
  25. In recent years, the reported infection cases by coxsackievirus (CV) have been on the rise. In order to reveal the relationship between the nucleotide and amino acid sequences and the viral virulence of the CV...

    Authors: Bin Liu, Zhe Li, Fengyang Xiang, Fan Li, Yang Zheng and Guoqing Wang
    Citation: Virology Journal 2014 11:33
  26. Using a murine model of parainfluenza virus infection (mPIV1 or Sendai virus; SeV), we compared the inflammatory responses to lethal and sub-lethal infections in inbred DBA/2 mice.

    Authors: Manika Suryadevara, Cynthia A Bonville, Helene F Rosenberg and Joseph B Domachowske
    Citation: Virology Journal 2013 10:357
  27. Using reverse genetics, we generated a recombinant low-pathogenic LaSota strain Newcastle disease virus (NDV) expressing the glycoprotein (GP) of Ebola virus (EBOV), designated rLa-EBOVGP, and evaluated its bi...

    Authors: Zhiyuan Wen, Bolin Zhao, Kun Song, Xule Hu, Weiye Chen, Dongni Kong, Jinying Ge and Zhigao Bu
    Citation: Virology Journal 2013 10:331
  28. Human respiratory syncytial virus (hRSV) is a leading cause of severe lower respiratory infection and a major public health threat worldwide. To date, no vaccine or effective therapeutic agent has been develop...

    Authors: Han-Bo Shin, Myung-Soo Choi, Byeol Ryu, Na-Rae Lee, Hye-In Kim, Hye-Eun Choi, Jun Chang, Kyung-Tae Lee, Dae Sik Jang and Kyung-Soo Inn
    Citation: Virology Journal 2013 10:303
  29. Hantaviruses cause acute hemorrhagic fever with renal syndrome (HFRS). Currently, several types of inactivated HFRS vaccines are widely used, however the limited ability of these immunogen to elicit neutralizi...

    Authors: Lan Yu, Wentao Bai, Xingan Wu, Liang Zhang, Lei Zhang, Puyuan Li, Fang Wang, Ziyu Liu, Fanglin Zhang and Zhikai Xu
    Citation: Virology Journal 2013 10:301
  30. Human metapneumovirus (HMPV) is now a major cause of lower respiratory infection in children. Although primary isolation of HMPV has been achieved in several different cell lines, the low level of virus replic...

    Authors: Liat Hui Loo, Muhammad Raihan Jumat, Yi Fu, Teck Choon Ayi, Pui San Wong, Nancy WS Tee, Boon Huan Tan and Richard J Sugrue
    Citation: Virology Journal 2013 10:294
  31. Newcastle disease virus (NDV) is the causative agent of the Newcastle disease, a severe disease in birds associated with substantial economic losses to the poultry industry worldwide. Sweden is situated along ...

    Authors: Conny Tolf, Michelle Wille, Ann-Katrin Haidar, Alexis Avril, Siamak Zohari and Jonas Waldenström
    Citation: Virology Journal 2013 10:285
  32. During 2009/10 a major measles epidemic caused by genotype B3 occurred in South Africa. Measles inclusion body encephalitis (MIBE) was diagnosed in a number of highly immuno-compromised HIV patients. The diagn...

    Authors: Diana R Hardie, Christine Albertyn, Jeannine M Heckmann and Heidi EM Smuts
    Citation: Virology Journal 2013 10:283
  33. Tacaribe virus (TCRV) is a less biohazardous relative of the highly pathogenic clade B New World arenaviruses that cause viral hemorrhagic fever syndromes and require handling in maximum containment facilities...

    Authors: Eric J Sefing, Min-Hui Wong, Deanna P Larson, Brett L Hurst, Arnaud J Van Wettere, Stewart W Schneller and Brian B Gowen
    Citation: Virology Journal 2013 10:221
  34. Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA.

    Authors: Gustavo Palacios, Naomi L Forrester, Nazir Savji, Amelia P A Travassos da Rosa, Hilda Guzman, Kelly DeToy, Vsevolod L Popov, Peter J Walker, W Ian Lipkin, Nikos Vasilakis and Robert B Tesh
    Citation: Virology Journal 2013 10:219
  35. Few studies have used quantitative polymerase chain reaction (qPCR) as an approach to measure virus neutralization assay endpoints. Its lack of use may not be surprising considering that sample nucleic acid ex...

    Authors: Jan C Varada, Belete Teferedegne, R Lynne Crim, Thembi Mdluli, Susette Audet, Keith Peden, Judy Beeler and Haruhiko Murata
    Citation: Virology Journal 2013 10:195
  36. Newcastle disease (ND) is one of the most deadly diseases of poultry around the globe. The disease is endemic in Pakistan and recurrent outbreaks are being reported regularly in wild captive, rural and commerc...

    Authors: Muhammad Zubair Shabbir, Siamak Zohari, Tahir Yaqub, Jawad Nazir, Muhammad Abu Bakr Shabbir, Nadia Mukhtar, Muhammad Shafee, Muhammad Sajid, Muhammad Anees, Muhammad Abbas, Muhammad Tanveer Khan, Asad Amanat Ali, Aamir Ghafoor, Abdul Ahad, Aijaz Ali Channa, Aftab Ahmad Anjum…
    Citation: Virology Journal 2013 10:170