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Herpes viruses

Section Editor: Blossom Damania, University of North Carolina at Chapel Hill, USA​​​​​​​ 
Deputy Section Editor: Anthony Nicola, Washington State University, USA​​​​​​​

The Herpes viruses section of Virology Journal includes research articles and reviews on both human and animal herpes viruses. This includes basic, mechanistic, and translational studies of herpes virus biology and pathogenesis. Topics include, but are not limited to, virus biology, virus entry, virus-host interactions, viral pathogenesis, viral cancers, antivirals and vaccines.

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  1. Gliomas are the most common brain tumors and include a variety of histologic types and grades of malignancy. They arise from glial cells and represent approximately 70% of the primary brain tumors. According t...

    Authors: Araceli Garcia-Martinez, Cristina Alenda, Esperanza Irles, Enrique Ochoa, Teresa Quintanar, Alvaro Rodriguez-Lescure, Jose L. Soto and Victor M. Barbera
    Citation: Virology Journal 2017 14:216
    Content type: Short Report Published on:

  2. Epstein–Barr virus (EBV) is closely associated with many human diseases, including a variety of deadly human malignant tumours. However, due to the lack of ideal animal models,the biological characteristics of...

    Authors: Zhi Wang, Xiang Yi, Long Du, Hong Wang, Jie Tang, Menglin Wang, Chenglin Qi, Heng Li, Yongjing Lai, Wei Xia and Anzhou Tang
    Citation: Virology Journal 2017 14:193
    Content type: Research Published on:

  3. There is little information regarding the duck enteritis virus (DEV) US10 gene and its molecular characterization.

    Authors: Daixi Zhang, Maoyin Lai, Anchun Cheng, Mingshu Wang, Ying Wu, Qiao Yang, Mafeng Liu, Dekang Zhu, Renyong Jia, Shun Chen, Kunfeng Sun, Xinxin Zhao and Xiaoyue Chen
    Citation: Virology Journal 2017 14:183
    Content type: Research Published on:

  5. Rift Valley fever virus (RVFV) is an arthropod-borne bunyavirus that can cause serious and fatal disease in humans and animals. RVFV is a negative-sense RNA virus of the Phlebovirus genus in the Bunyaviridae fami...

    Authors: Abdelrahman Said, Mona Elmanzalawy, Guanggang Ma, Armando Mario Damiani and Nikolaus Osterrieder
    Citation: Virology Journal 2017 14:154
    Content type: Short Report Published on:

  6. Preeclampsia is a major health problem. Although, the pathophysiology of preeclampsia is not fully understood, there are recent studies on association between infections and preeclampsia.

    Authors: Shimos A. Alshareef, Ahmed M. Eltom, Abubakr M. Nasr, Hamdan Z. Hamdan and Ishag Adam
    Citation: Virology Journal 2017 14:142
    Content type: Research Published on:

  7. Cytomegalovirus (CMV) infection occurs frequently and is widespread globally. Numerous studies have shown that various types of immune cells play roles in mediating the response to CMV infection. CD11c, a comm...

    Authors: Yi Liao, Xinglou Liu, Yuan Huang, Heyu Huang, Yuanyuan Lu, Yanan Zhang, Sainan Shu and Feng Fang
    Citation: Virology Journal 2017 14:132
    Content type: Research Published on:

  8. Epstein-Barr Virus (EBV) is associated with hematopoietic malignancies, such as Burkitt’s lymphoma, post-transplantation lymphoproliferative disorder, and diffuse large B-cell lymphoma. The current approach fo...

    Authors: Qinyan Yin, Mark Sides, Christopher H. Parsons, Erik K. Flemington and Joseph A. Lasky
    Citation: Virology Journal 2017 14:121
    Content type: Research Published on:

  9. Primary Human herpesvirus-7 (HHV-7) infection usually occurs during childhood and causes several clinical manifestations: mainly exanthem subitum (roseola infantum), followed by a lifelong latent state with possi...

    Authors: Mónica Parra, Adoración Alcala, Cristina Amoros, Anna Baeza, Antonio Galiana, David Tarragó, Miguel Ángel García-Quesada and Victoria Sánchez-Hellín
    Citation: Virology Journal 2017 14:97
    Content type: Case Report Published on:

  10. Human cytomegalovirus (HCMV) is the most common cause of intrauterine infections worldwide. The toll-like receptors (TLRs) have been reported as important factors in immune response against HCMV. Particularly,...

    Authors: Wioletta Wujcicka, Edyta Paradowska, Mirosława Studzińska, Jan Wilczyński and Dorota Nowakowska
    Citation: Virology Journal 2017 14:64
    Content type: Research Published on:

  11. Acyclovir (ACV)-resistant (ACVr) herpes simplex virus type 1 (HSV-1) infections are concern in immunocompromised patients. Most clinical ACVr HSV-1 isolates have mutations in the viral thymidine kinase (vTK) g...

    Authors: Natsumi Omura, Hikaru Fujii, Tomoki Yoshikawa, Souichi Yamada, Shizuko Harada, Takuya Inagaki, Miho Shibamura, Haruko Takeyama and Masayuki Saijo
    Citation: Virology Journal 2017 14:59
    Content type: Research Published on:

  12. Epstein-Barr virus (EBV) and human cytomegalovirus (CMV) infections are environmental risk factors affecting the outcome of cancer due to an impairment in the cell-mediated immunity. Therefore, this study aime...

    Authors: Samah Aly Loutfy, Maha A. Abo-Shadi, Mohamed Fawzy, Mohamed El-Wakil, Shimaa A. Metwally, Manar M. Moneer, Nasra F. Abdel Fattah, Sara Kassem and Ahmed Elgebaly
    Citation: Virology Journal 2017 14:46
    Content type: Research Published on:

  13. Herpes simplex virus type 1 (HSV-1) cause not only mild symptoms but also blindness and encephalitis. It was previously shown that the immune response against HSV-1 occurs mainly in the trigeminal ganglia (TG)...

    Authors: Natália Lucinda, Maria Marta Figueiredo, Natália Lima Pessoa, Beatriz Senra Álvares da Silva Santos, Graciela Kunrath Lima, Arthur Molinari Freitas, Alexandre Magalhães Vieira Machado, Erna Geessien Kroon, Lis Ribeiro do Valle Antonelli and Marco Antônio Campos
    Citation: Virology Journal 2017 14:37
    Content type: Research Published on:

  14. Herpes simplex virus 1 (HSV-1) is an archetypal member of the alphaherpesvirus subfamily with a large genome encoding over 80 proteins, many of which play a critical role in virus-host interactions and immune ...

    Authors: Chunfu Zheng and Chenhe Su
    Citation: Virology Journal 2017 14:35
    Content type: Research Published on:

  15. AIM2, a cytosolic DNA sensor, plays an important role during infection caused by pathogens with double-stranded DNA; however, its role in human cytomegalovirus (HCMV) infection remains unclear. Previously, we ...

    Authors: Yuan Huang, Di Ma, Heyu Huang, Yuanyuan Lu, Yi Liao, Lingling Liu, Xinglou Liu and Feng Fang
    Citation: Virology Journal 2017 14:34
    Content type: Research Published on:

  16. Human cytomegalovirus (HCMV) is responsible for the most common intrauterine infections, which may be acquired congenitally from infected pregnant woman to fetus. The research was aimed to estimate the role of...

    Authors: Wioletta Wujcicka, Edyta Paradowska, Mirosława Studzińska, Jan Wilczyński and Dorota Nowakowska
    Citation: Virology Journal 2017 14:12
    Content type: Research Published on:

  17. Human herpesviruses have been hypothesized as environmental triggers in the development of autoimmune thyroid diseases (AITD), and in particular active human herpesvirus 6A (HHV-6A) infection was detected in t...

    Authors: Elisabetta Caselli, Maria D’Accolti, Irene Soffritti, Maria Chiara Zatelli, Roberta Rossi, Ettore degli Uberti and Dario Di Luca
    Citation: Virology Journal 2017 14:3
    Content type: Short report Published on:

  18. Human cytomegalovirus (HCMV) is an opportunistic pathogen leading to severe and even fatal diseases in ‘at-risk’ categories of individuals upon primary infection or the symptomatic reactivation of the endogeno...

    Authors: Maria-Cristina Arcangeletti, Rosita Vasile Simone, Isabella Rodighiero, Flora De Conto, Maria-Cristina Medici, Clara Maccari, Carlo Chezzi and Adriana Calderaro
    Citation: Virology Journal 2016 13:179
    Content type: Research Published on:

  19. Herpes simplex virus type 1 (HSV1), a member of the alphaherpesvirinae, can cause recurrent facial lesions and encephalitis. Two membrane envelopment processes, one at the inner nuclear membrane and a second a...

    Authors: Melanie Ott, Débora Marques, Christina Funk and Susanne M. Bailer
    Citation: Virology Journal 2016 13:175
    Content type: Research Published on:

  20. HSV-2 is the major cause of genital herpes. We previously demonstrated that the host viral restriction factor tetherin restricts HSV-2 release and is antagonized by several HSV-2 glycoproteins. However, the me...

    Authors: Yalan Liu, Mei Li, Di Zhang, Mudan Zhang and Qinxue Hu
    Citation: Virology Journal 2016 13:154
    Content type: Research Published on:

  21. UL7, a tegument protein of Herpes Simplex Virus type I (HSV-1), is highly conserved in viral infection and proliferation and has an unknown mechanism of action.

    Authors: Xingli Xu, Shengtao Fan, Jienan Zhou, Ying Zhang, Yanchun Che, Hongzhi Cai, Lichun Wang, Lei Guo, Longding Liu and Qihan Li
    Citation: Virology Journal 2016 13:152
    Content type: Research Published on:

  22. The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that transforms B cells and causes several malignancies including Burkitt’s lymphoma. EBV differentially expresses at least 49 mature microRNAs (miRNAs)...

    Authors: Cecelia Harold, Diana Cox and Kasandra J. Riley
    Citation: Virology Journal 2016 13:145
    Content type: Short report Published on:

  23. One of the most important functions of long noncoding RNAs (lncRNAs) is to control protein coding gene transcription by acting locally in cis, or remotely in trans. Herpes Simplex Virus type I (HSV-1) latently...

    Authors: Benxia Hu, Yongxia Huo, Guijun Chen, Liping Yang, Dongdong Wu and Jumin Zhou
    Citation: Virology Journal 2016 13:137
    Content type: Research Published on:

  25. Herpes simplex virus (HSV) is the most common identified cause of focal encephalitis worldwide. However, postoperative HSV encephalitis (HSVE) is a rare complication of neurosurgical procedures and a significa...

    Authors: David A. Jaques, Spyridoula Bagetakou, Arnaud G. L’Huillier, Andrea Bartoli, Maria-Isabel Vargas, Joel Fluss and Laurent Kaiser
    Citation: Virology Journal 2016 13:83
    Content type: Case Report Published on:

  26. Replication of viral genome is the central event during the lytic infectious cycle of herpes simplex virus 1 (HSV-1). However, the details of HSV-1 replication process are still elusive due to the limitations ...

    Authors: Zhuoran Li, Ce Fang, Yuanyuan Su, Hongmei Liu, Fengchao Lang, Xin Li, Guijun Chen, Danfeng Lu and Jumin Zhou
    Citation: Virology Journal 2016 13:65
    Content type: Research Published on:

  29. Investigating the neutralizing antibody (NAb) titer against HSV-1 is essential for monitoring the immune protection against HSV-1 in susceptible populations, which would facilitate the development of vaccines ...

    Authors: Yong Luo, Dan Xiong, Huan-Huan Li, Sheng-Ping Qiu, Chao-Long Lin, Qin Chen, Cheng-Hao Huang, Quan Yuan, Jun Zhang and Ning-Shao Xia
    Citation: Virology Journal 2016 13:44
    Content type: Methodology Published on:

  30. Herpes simplex virus type-2 is the common cause of genital ulcer disease worldwide. Genital herpes infection is a major concern in pregnancy due to the risk of neonatal transmission.

    Authors: Antehun Alemayehu Anjulo, Tamrat Abebe, Feleke Hailemichael and Adane Mihret
    Citation: Virology Journal 2016 13:43
    Content type: Research Published on:

  31. Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide ran...

    Authors: Chenhe Su, Guoqing Zhan and Chunfu Zheng
    Citation: Virology Journal 2016 13:38
    Content type: Review Published on:

  33. Marek’s disease is a virus disease with worldwide distribution that causes major losses to poultry production. Vaccines against Marek’s disease virus, an oncogenic alphaherpesvirus, reduce tumour formation but...

    Authors: Mathilde Couteaudier, Katia Courvoisier, Laetitia Trapp-Fragnet, Caroline Denesvre and Jean-François Vautherot
    Citation: Virology Journal 2016 13:7
    Content type: Short report Published on:

  34. Epstein-Barr virus (EBV) was the first virus identified to encode microRNAs (miRNAs). Both of viral and human cellular miRNAs are important in EBV infection. However, the dynamic expression profile of miRNAs d...

    Authors: Liwei Gao, Junhong Ai, Zhengde Xie, Chen Zhou, Chunyan Liu, Hui Zhang and Kunling Shen
    Citation: Virology Journal 2015 12:208
    Content type: Research Published on:

  36. Human cytomegalovirus (HCMV) is still considered to be the main viral cause of birth defects and long-term neurological and sensory sequelae following congenital infection.

    Authors: Maria-Cristina Arcangeletti, Rosita Vasile Simone, Isabella Rodighiero, Flora De Conto, Maria-Cristina Medici, Davide Martorana, Carlo Chezzi and Adriana Calderaro
    Citation: Virology Journal 2015 12:202
    Content type: Research Published on:

  37. The UL54 protein of Duck Enteritis Virus (DEV) is a homolog of herpes simplex virus-1 (HSV-1) immediate-early infectious cell protein 27 (ICP27), a multifunctional protein essential for viral infection. Noneth...

    Authors: Chaoyue Liu, Anchun Cheng, Mingshu Wang, Shun Chen, Renyong Jia, Dekang Zhu, Mafeng Liu, Kunfeng Sun, Qiao Yang and Xiaoyue Chen
    Citation: Virology Journal 2015 12:198
    Content type: Research Published on:

  38. Gammaherpesviruses (GHVs) are a large group of dsDNA viruses that can infect humans and several animal species. The two human GHVs, Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus are known for ...

    Authors: Reinhard Ertl, Melanie Korb, Ines Langbein-Detsch and Dieter Klein
    Citation: Virology Journal 2015 12:146
    Content type: Short report Published on:

  39. NK/T cell lymphoma is an aggressive lymphoma almost always associated with EBV. BamHI-A rightward open reading frame 1 (BARF1) and BamHI-H rightward open reading frame 1 (BHRF1) are two EBV early genes, which ...

    Authors: Lingling Sun, Kui Che, Zhenzhen Zhao, Song Liu, Xiaoming Xing and Bing Luo
    Citation: Virology Journal 2015 12:135
    Content type: Research Published on:

  41. Highly pathogenic avian influenza virus (AIV) subtype H5N1 remains a threat to poultry. Duck enteritis virus (DEV)-vectored vaccines expressing AIV H5N1 hemagglutinin (HA) may be viable AIV and DEV vaccine can...

    Authors: Jichun Wang, Aimin Ge, Mengwei Xu, Zhisheng Wang, Yongfeng Qiao, Yiqi Gu, Chang Liu, Yamei Liu and Jibo Hou
    Citation: Virology Journal 2015 12:126
    Content type: Research Published on:

  43. In Korea, every vaccine lot is tested by the National Center for Lot Release (NCLR) in accordance with the national lot release procedures to ensure the safety and efficacy of vaccines. These quality tests exa...

    Authors: JiYoung Hong, Ho Jung Oh, Naery Lee, Do-Keun Kim, Heui-Seong Yoon, Yeon-Tae Kim, Seokkee Chang, Jae-Hak Park and Hyejoo Chung
    Citation: Virology Journal 2015 12:101
    Content type: Research Published on:

  44. KSHV is a tumorigenic γ-herpesvirus that has been identified as the etiologic agent of Kaposi’s sarcoma (KS), a multifocal highly vascularized neoplasm that is the most common malignancy associated with acquir...

    Authors: Magdalena Angelova, MaryBeth Ferris, Kenneth F Swan, Harris E McFerrin, Gabriella Pridjian, Cindy A Morris and Deborah E Sullivan
    Citation: Virology Journal 2014 11:218
    Content type: Short report Published on:

  45. Herpes viruses infection transmitted through healthy but infected blood donors pose a danger to herpes-naive immunocompromised recipients. The risk of transfusion-related HHV-8 transmission is different in end...

    Authors: Marianna Politou, Dimitrios Koutras, Georgios Kaparos, Serena Valsami, Theodoros Pittaras, Emmanouil Logothetis, George Panayiotakopoulos and Evangelia Kouskouni
    Citation: Virology Journal 2014 11:153
    Content type: Short report Published on:

  47. Oral mucosa is frequently exposed to Herpes simplex virus type 1 (HSV-1) infection and irradiation due to dental radiography. During radiotherapy for oral cancer, the surrounding clinically normal tissues are ...

    Authors: Aaro Turunen, Veijo Hukkanen, Michaela Nygårdas, Jarmo Kulmala and Stina Syrjänen
    Citation: Virology Journal 2014 11:125
    Content type: Research Published on:
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  • ISSN: 1743-422X (electronic)

Virology Journal

ISSN: 1743-422X