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Herpes viruses

Section Editor: Blossom Damania, University of North Carolina at Chapel Hill, USA​​​​​​​ 
Deputy Section Editor: Anthony Nicola, Washington State University, USA​​​​​​​

The Herpes viruses section of Virology Journal includes research articles and reviews on both human and animal herpes viruses. This includes basic, mechanistic, and translational studies of herpes virus biology and pathogenesis. Topics include, but are not limited to, virus biology, virus entry, virus-host interactions, viral pathogenesis, viral cancers, antivirals and vaccines.

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  1. Content type: Research

    Human cytomegalovirus (HCMV) is still considered to be the main viral cause of birth defects and long-term neurological and sensory sequelae following congenital infection.

    Authors: Maria-Cristina Arcangeletti, Rosita Vasile Simone, Isabella Rodighiero, Flora De Conto, Maria-Cristina Medici, Davide Martorana, Carlo Chezzi and Adriana Calderaro

    Citation: Virology Journal 2015 12:202

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  2. Content type: Research

    The UL54 protein of Duck Enteritis Virus (DEV) is a homolog of herpes simplex virus-1 (HSV-1) immediate-early infectious cell protein 27 (ICP27), a multifunctional protein essential for viral infection. Noneth...

    Authors: Chaoyue Liu, Anchun Cheng, Mingshu Wang, Shun Chen, Renyong Jia, Dekang Zhu, Mafeng Liu, Kunfeng Sun, Qiao Yang and Xiaoyue Chen

    Citation: Virology Journal 2015 12:198

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  3. Content type: Short report

    Gammaherpesviruses (GHVs) are a large group of dsDNA viruses that can infect humans and several animal species. The two human GHVs, Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus are known for ...

    Authors: Reinhard Ertl, Melanie Korb, Ines Langbein-Detsch and Dieter Klein

    Citation: Virology Journal 2015 12:146

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  4. Content type: Research

    NK/T cell lymphoma is an aggressive lymphoma almost always associated with EBV. BamHI-A rightward open reading frame 1 (BARF1) and BamHI-H rightward open reading frame 1 (BHRF1) are two EBV early genes, which ...

    Authors: Lingling Sun, Kui Che, Zhenzhen Zhao, Song Liu, Xiaoming Xing and Bing Luo

    Citation: Virology Journal 2015 12:135

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  5. Content type: Research

    Highly pathogenic avian influenza virus (AIV) subtype H5N1 remains a threat to poultry. Duck enteritis virus (DEV)-vectored vaccines expressing AIV H5N1 hemagglutinin (HA) may be viable AIV and DEV vaccine can...

    Authors: Jichun Wang, Aimin Ge, Mengwei Xu, Zhisheng Wang, Yongfeng Qiao, Yiqi Gu, Chang Liu, Yamei Liu and Jibo Hou

    Citation: Virology Journal 2015 12:126

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  6. Content type: Research

    In Korea, every vaccine lot is tested by the National Center for Lot Release (NCLR) in accordance with the national lot release procedures to ensure the safety and efficacy of vaccines. These quality tests exa...

    Authors: JiYoung Hong, Ho Jung Oh, Naery Lee, Do-Keun Kim, Heui-Seong Yoon, Yeon-Tae Kim, Seokkee Chang, Jae-Hak Park and Hyejoo Chung

    Citation: Virology Journal 2015 12:101

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  7. Content type: Short report

    KSHV is a tumorigenic γ-herpesvirus that has been identified as the etiologic agent of Kaposi’s sarcoma (KS), a multifocal highly vascularized neoplasm that is the most common malignancy associated with acquir...

    Authors: Magdalena Angelova, MaryBeth Ferris, Kenneth F Swan, Harris E McFerrin, Gabriella Pridjian, Cindy A Morris and Deborah E Sullivan

    Citation: Virology Journal 2014 11:218

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  8. Content type: Short report

    Herpes viruses infection transmitted through healthy but infected blood donors pose a danger to herpes-naive immunocompromised recipients. The risk of transfusion-related HHV-8 transmission is different in end...

    Authors: Marianna Politou, Dimitrios Koutras, Georgios Kaparos, Serena Valsami, Theodoros Pittaras, Emmanouil Logothetis, George Panayiotakopoulos and Evangelia Kouskouni

    Citation: Virology Journal 2014 11:153

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  9. Content type: Research

    Oral mucosa is frequently exposed to Herpes simplex virus type 1 (HSV-1) infection and irradiation due to dental radiography. During radiotherapy for oral cancer, the surrounding clinically normal tissues are ...

    Authors: Aaro Turunen, Veijo Hukkanen, Michaela Nygårdas, Jarmo Kulmala and Stina Syrjänen

    Citation: Virology Journal 2014 11:125

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  10. Content type: Research

    Epstein-Barr virus (EBV) is associated with 20-40% of Hodgkin’s Lymphoma (HL) cases. EBV-encoded latent membrane protein 1 (LMP1) is a well-known oncogenic protein and two C-terminal deletion variants, del30-L...

    Authors: Charlotte Sueur, Julien Lupo, Philippe Mas, Patrice Morand and Véronique Boyer

    Citation: Virology Journal 2014 11:94

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  11. Content type: Review

    Since the type of herpes simplex virus (HSV) infection affects prognosis and subsequent counseling, type-specific testing to distinguish HSV-1 from HSV-2 is always recommended. Although PCR has been the diagno...

    Authors: Jérôme LeGoff, Hélène Péré and Laurent Bélec

    Citation: Virology Journal 2014 11:83

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    The Erratum to this article has been published in Virology Journal 2015 12:167

  12. Content type: Methodology

    Murine cytomegalovirus (MCMV) is increasingly used as an infectious model to investigate host-pathogen interactions in mice. Detailed methods have been published for using primary murine embryonic fibroblasts ...

    Authors: Katherine A Zurbach, Toktam Moghbeli and Christopher M Snyder

    Citation: Virology Journal 2014 11:71

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  13. Content type: Research

    Herpesviruses are ubiquitous pathogens that infect and cause recurrent disease in multiple animal species. Feline herpesvirus-1 (FHV-1), a member of the alphaherpesvirus family, causes respiratory illness and ...

    Authors: Samantha L Semenkow, Nicole M Johnson, David J Maggs and Barry J Margulies

    Citation: Virology Journal 2014 11:34

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  14. Content type: Research

    Epstein-Barr Virus (EBV) latently infects ~10% of gastric carcinomas (GC). Epstein-Barr Nuclear Antigen 1 (EBNA1) is expressed in EBV-associated GC, and can bind host DNA, where it may impact cellular gene reg...

    Authors: Fang Lu, Italo Tempera, Hyunna T Lee, Karen DeWispelaere and Paul M Lieberman

    Citation: Virology Journal 2014 11:12

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  15. Content type: Research

    HCMV encodes a stable 5 kb RNA of unknown function that is conserved across cytomegalovirus species. In vivo studies of the MCMV orthologue, a 7.2 kb RNA, demonstrated that viruses that do not express the RNA fai...

    Authors: Toni M Schwarz, Lysa-Anne M Volpe, Christopher G Abraham and Caroline A Kulesza

    Citation: Virology Journal 2013 10:348

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  16. Content type: Research

    Herpes simplex virus type-1(HSV-1) and HSV-2 are important human pathogens that cause significant ocular and urogenital complications, respectively. We have previously shown that HSV-1 virions lacking glycopro...

    Authors: Arun V Iyer, Bapi Pahar, Vladimir N Chouljenko, Jason D Walker, Brent Stanfield and Konstantin G Kousoulas

    Citation: Virology Journal 2013 10:317

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  17. Content type: Research

    Epstein-Barr virus (EBV) is an etiological cause of many human lymphocytic and epithelial malignancies. EBV expresses different genes that are associated with three latency types. To date, as many as 44 EBV-en...

    Authors: Hong-Jie Yang, Tie-Jun Huang, Chang-Fu Yang, Li-Xia Peng, Ran-Yi Liu, Guang-Da Yang, Qiao-Qiao Chu, Jia-Ling Huang, Na Liu, Hong-Bing Huang, Zhen-Yu Zhu, Chao-Nan Qian and Bi-Jun Huang

    Citation: Virology Journal 2013 10:314

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  18. Content type: Research

    Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus that infects humans and results in chickenpox and herpes zoster. A number of VZV genes remain functionally uncharacterized and since VZV is an obl...

    Authors: Christine Meyer, Jesse Dewane, Kristen Haberthur, Flora Engelmann, Nicole Arnold, Wayne Gray and Ilhem Messaoudi

    Citation: Virology Journal 2013 10:278

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  19. Content type: Research

    Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide, and novel treatment modalities to improve the prognosis of patients with advanced disease are highly desirable. On...

    Authors: Jhy-Ming Li, Kuo-Chin Kao, Li-Fu Li, Tsung-Ming Yang, Chean-Ping Wu, Yan-Ming Horng, William WG Jia and Cheng-Ta Yang

    Citation: Virology Journal 2013 10:241

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  20. Content type: Research

    The MCMV major immediate early promoter/enhancer (MIEP) is a bidirectional promoter that drives the expression of the three immediate early viral genes, namely ie1, ie2 and ie3. The regulation of their express...

    Authors: Franziska Dag, Adrien Weingärtner, Milada Butueva, Ianina Conte, Julia Holzki, Tobias May, Barbara Adler, Dagmar Wirth and Luka Cicin-Sain

    Citation: Virology Journal 2013 10:197

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  21. Content type: Review

    Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate infections. Understanding of virus entry via endocytosis is critically important for the design of antiviral strateg...

    Authors: Eric Barrow, Anthony V Nicola and Jin Liu

    Citation: Virology Journal 2013 10:177

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  22. Content type: Research

    A severe MD was broken out at a farm in Shandong, China, despite FC126 vaccination of the chickens at 1-day-old. The mortality of the flocks reached up to 38.3%. The infected chickens were found to have MD pat...

    Authors: Zhenhua Gong, Lijuan Zhang, Jianlin Wang, Linlin Chen, Hu Shan, Zhiliang Wang and Hongchao Ma

    Citation: Virology Journal 2013 10:155

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