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Hepatitis viruses

Section Editor: Alan McLachlan, University of Illinois at Chicago, USA 
Deputy Section Editor: Susan Uprichard, Loyola University Medical Center​​​​​​​, USA 

The Hepatitis viruses section of Virology Journal includes studies relating to all aspects of hepatitis A, B C, D and E virus research including research discoveries addressing both basic and medical aspects of the biology of these human pathogens. Basic research topics of interest include all aspects of the viral life cycle (e.g. viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress) and viral-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants.

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  1. Content type: Research

    The suppressor of cytokine signaling family (SOCS) is an important negative regulator in the JAK-STAT signaling pathway. This study was designed to explore the correlation between SOCS-1, 2 and 3, Hepatitis B ...

    Authors: Ling-yao Du, Yao-li Cui, En-qiang Chen, Xing Cheng, Li Liu and Hong Tang

    Citation: Virology Journal 2014 11:51

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  2. Content type: Research

    Hepatitis C virus is a persistent epidemiological problem, with an estimated 170 million individuals infected worldwide, and the leading cause of asymptomatic chronic infection, liver cirrhosis and hepatocellu...

    Authors: Roxana-Delia Trimbitas, Fatima Zahra Serghini, Fatiha Lazaar, Warda Baha, Abderrahim Foullous, Mohammed Essalhi, Abdelouahed El Malki, Abdelkrim Meziane Bellefquih and Abdelouaheb Bennani

    Citation: Virology Journal 2014 11:43

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  3. Content type: Research

    Currently, sharing of drug paraphernalia is the main form of HCV transmission worldwide. In South America, consistent findings indicate that shared sniffing equipment is an important factor in the spread of HC...

    Authors: Aldemir B Oliveira-Filho, Leila Sawada, Laine C Pinto, Daiane Locks, Santana L Bahia, JairoA A Castro, Renata B Hermes, Igor Brasil-Costa, CarlosE M Amaral and José Alexandre R Lemos

    Citation: Virology Journal 2014 11:38

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  4. Content type: Research

    Hepatitis B virus (HBV) transcription and replication are essentially restricted to hepatocytes. Based on the HBV enhancer and promoter complex that links hepatic glucose metabolism to its transcription and re...

    Authors: Xiaohui Tian, Fei Zhao, Weihua Sun, Xiaoguang Zhi, Zhikui Cheng, Ming Zhou and Kanghong Hu

    Citation: Virology Journal 2014 11:30

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  5. Content type: Short report

    Hepatitis C virus (HCV) is highly infectious pathogen which is responsible for causing Hepatitis around 200 million individuals worldwide. In Pakistan, 4.7% of HCV prevalence has been reported and HCV genotype...

    Authors: Suliman Qadir Afridi, Muhammad Muddassir Ali, Furqan Awan, Muhammad Nauman Zahid, Irfan Qadir Afridi, Sara Qadir Afridi and Tahir Yaqub

    Citation: Virology Journal 2014 11:24

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  6. Content type: Methodology

    Currently there is a significant risk of infection with hepatitis B virus (HBV) during blood transfusion in high epidemic area. This is due to the pre-seroconversion window period, immunovariant viral strains ...

    Authors: Alcione de Oliveira dos Santos, Luan Felipo Botelho Souza, Lourdes Maria Borzacov, Juan Miguel Villalobos-Salcedo and Deusilene Souza Vieira

    Citation: Virology Journal 2014 11:16

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  7. Content type: Case Report

    Co-infections with HBV (hepatitis B virus) occur in HIV (human immunodeficiency virus) patients frequently. It has been reported that an effective treatment of HIV can also lead to a suppression of HBV and to ...

    Authors: Rongjuan Pei, Sebastian Grund, Jens Verheyen, Stefan Esser, Xinwen Chen and Mengji Lu

    Citation: Virology Journal 2014 11:9

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  8. Content type: Research

    Direct-acting antiviral (DAA) agents target HCV proteins; some of these have already been approved for the treatment of HCV infection, while others are in development. However, selection of DAA-resistant viral...

    Authors: Stefania Paolucci, Loretta Fiorina, Bianca Mariani, Roberto Gulminetti, Stefano Novati, Giorgio Barbarini, Raffaele Bruno and Fausto Baldanti

    Citation: Virology Journal 2013 10:355

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  9. Content type: Research

    Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma and infects about 3% world population. Response to interferon therapy depends upon the genotype of the virus and factors...

    Authors: Atika Mansoor, Lubna Ali, Noor-ul Sabah, Asraf Hussain Hashmi, Mohammad Haroon Khan, Syed Ali Raza Kazmi, Nafees Ahmad, Saima Siddiqi and Khalid Mehmood Khan

    Citation: Virology Journal 2013 10:352

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  10. Content type: Research

    Although hepatitis C virus (HCV) is primarily hepatotropic, markers of HCV replication were detected in peripheral blood mononuclear cells (PBMC) as well as in ex vivo collected tissues and organs. Specific strai...

    Authors: Agnieszka Pawełczyk, Natalia Kubisa, Joanna Jabłońska, Iwona Bukowska-Ośko, Kamile Caraballo Cortes, Maria Fic, Tomasz Laskus and Marek Radkowski

    Citation: Virology Journal 2013 10:346

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  11. Content type: Case Report

    Using various methods, we analyzed the cause of death among weaned pigs from a pig farm in Hebei Province, China. All 300 piglets (100% fatality) were identified as moribund, with death occurring within 1 mont...

    Authors: Jingjing Mao, Yue Zhao, Ruiping She, Peng Xiao, Jijing Tian and Jian Chen

    Citation: Virology Journal 2013 10:341

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  12. Content type: Research

    An animal model for HBV that more closely approximates the disease in humans is needed. The tree shrew (Tupaia belangeri) is closely related to primates and susceptible to HBV. We previously established that neon...

    Authors: Ping Ruan, Chun Yang, Jianjia Su, Ji Cao, Chao Ou, Chengpiao Luo, Yanping Tang, Qi Wang, Fang Yang, Junlin Shi, Xiaoxu Lu, Linqun Zhu, Hong Qin, Wen Sun, Yuanzhi Lao and Yuan Li

    Citation: Virology Journal 2013 10:333

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  13. Content type: Research

    Continuous long-term treatment is recommended to reduce the hepatitis B virus (HBV) viral load. However, as a consequence, resistance mutations can emerge and be transmitted to other individuals. The polymeras...

    Authors: Nathalia Mantovani, Maira Cicero, Luiz Claudio Santana, Carla Silveira, Eliane Pereira do Carmo, Paulo Roberto Ferreira Abrão, Ricardo Sobhie Diaz, Marcos Montani Caseiro and Shirley Vasconcelos Komninakis

    Citation: Virology Journal 2013 10:320

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  14. Content type: Research

    Antiviral drug-resistant HBV mutants are complex and currently partly understood. This study was performed to analyze the profile of hepatitis B virus (HBV) resistance mutations against nucleos(t)ide analogues...

    Authors: Jun Lei, Ying Wang, Li-Li Wang, Shao-Jun Zhang, Wei Chen, Zhi-Gang Bai and Lv-Ye Xu

    Citation: Virology Journal 2013 10:313

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  15. Content type: Short report

    Hepatitis B virus (HBV) induces proliferation of human mesangial cells (HMCs), and extracellular matrix expression through the deposition of immune complexes in renal tissue. However, it is unclear whether HBV...

    Authors: Zongli Diao, Jiaxiang Ding, Chenghong Yin, Liyan Wang and Wenhu Liu

    Citation: Virology Journal 2013 10:300

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  16. Content type: Review

    The current standard of care (SOC) for hepatitis C virus (HCV) infection is the combination of pegylated interferon (PEG-IFN), Ribavirin and protease inhibitor for HCV genotype 1. Nevertheless, this treatment ...

    Authors: Muhammad Imran, Sobia Manzoor, Javed Ashraf, Madiha Khalid, Muqddas Tariq, Hafiza Madeha Khaliq and Sikandar Azam

    Citation: Virology Journal 2013 10:299

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  17. Content type: Research

    CTL escape mutations have been described during acute hepatitis C in patients who developed chronic disease later on. Our aim was to investigate the mutual relationship between HCV specific CD8+ T cells and ev...

    Authors: Axel Ulsenheimer, Gláucia Paranhos-Baccalà, Florence Komurian-Pradel, Bijan Raziorrouh, Peter Kurktschiev, Helmut M Diepolder, Reinhart Zachoval, Michael Spannagl, Maria-Christina Jung and Norbert H Gruener

    Citation: Virology Journal 2013 10:295

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  18. Content type: Research

    Selective pressure from either the immune response or the use of nucleoside analogs in antiviral therapy could be driving the emergence of HBV mutants. Because of the overlap of the open reading frame (ORF) S for...

    Authors: Mingshun Zhang, Guohong Ge, Yonglin Yang, Xubing Cai, Qiang Fu, Jie Cai and Zuhu Huang

    Citation: Virology Journal 2013 10:292

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  19. Content type: Research

    Majority of previous studies of pegylated interferon α-2a (PegIFNα-2a) forced on naïve chronic hepatitis B (CHB) patients, and the data of PegIFNα-2a in therapy of patients with prior exposure to nucleos(t)ide...

    Authors: Min Weng, Wei-Zheng Zeng, Xiao-Ling Wu, Yong Zhang, Ming-De Jiang, Zhao Wang, De-Jiang Zhou and Xuan He

    Citation: Virology Journal 2013 10:277

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  20. Content type: Research

    Hepatitis C virus (HCV) is a major cause of liver disease and a potential cause of substantial morbidity and mortality worldwide. The overall prevalence of HCV infection is 2%, representing 120 million people ...

    Authors: Tutik Sri Wahyuni, Lydia Tumewu, Adita Ayu Permanasari, Evhy Apriani, Myrna Adianti, Abdul Rahman, Aty Widyawaruyanti, Maria Inge Lusida, Achmad Fuad, Soetjipto, Nasronudin, Hiroyuki Fuchino, Nobuo Kawahara, Ikuo Shoji, Lin Deng, Chie Aoki…

    Citation: Virology Journal 2013 10:259

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  21. Content type: Research

    Hepatitis B virus (HBV) infection is a major global health problem. The infectious virion contains an inner “core particle”, which is made of 180 or 240 copies of core protein, alternatively known as hepatitis...

    Authors: Guangyu Xu, Chengguo Wei, Yuqi Guo, Chao Zhang, Nan Zhang and Guoqing Wang

    Citation: Virology Journal 2013 10:256

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  22. Content type: Review

    The disproportionate imbalance between the systemic manifestation of reactive oxygen species and body’s ability to detoxify the reactive intermediates is referred to as oxidative stress. Several biological pro...

    Authors: Usman Zafar Paracha, Kaneez Fatima, Mohammad Alqahtani, Adeel Chaudhary, Adel Abuzenadah, Ghazi Damanhouri and Ishtiaq Qadri

    Citation: Virology Journal 2013 10:251

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  23. Content type: Research

    Hepatitis B virus (HBV) genotype F (HBV/F) is considered to be indigenous to the Americas, but its emergence and spread in the continent remain unknown. Previously, only two HBV/F complete genome sequences fro...

    Authors: Francisco CA Mello, Oscar C Araujo, Barbara V Lago, Ana Rita C Motta-Castro, Marcia Terezinha B Moraes, Selma A Gomes, Gonzalo Bello and Natalia M Araujo

    Citation: Virology Journal 2013 10:236

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  24. Content type: Research

    Little is known about HBV-specific T-cell responses in chronic Hepatitis B patients (HBV) that are co-infected with Human immunodeficiency virus type 1 (HIV-1), especially those with normal alanine aminotransf...

    Authors: Xin Zhang, Hanqian Xing, Xia Feng, Haiping Zhang, Yi Wang and Huiping Yan

    Citation: Virology Journal 2013 10:232

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  25. Content type: Research

    It has been suggested that different hepatitis B virus (HBV) genotypes may have distinct virological characteristics that correlate with clinical outcomes during antiviral therapy and the natural course of inf...

    Authors: Lei Li, Hong Shen, Anyi Li, Zhenhua Zhang, Baoju Wang, Junzhong Wang, Xin Zheng, Jun Wu, Dongliang Yang, Mengji Lu and Jingjiao Song

    Citation: Virology Journal 2013 10:214

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  26. Content type: Research

    The prevalence of HCV infection has increased during recent years and the incidence reach 3% of the world's population, and in some countries like Egypt, may around 20%. The developments of effective and preve...

    Authors: Esmail M EL-Fakharany, Lourdes Sánchez, Hussein A Al-Mehdar and Elrashdy M Redwan

    Citation: Virology Journal 2013 10:199

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  27. Content type: Research

    To evaluate the efficacy and safety of Entecavir (ETV) plus adefovir (ADV) for chronic hepatitis B (CHB) patients after multiple nucleos(t)ide analogue (NAs) failure treatment.

    Authors: Xian-Hua Xu, Gai-Li Li, Yang Qin, Qiang Li, Fa-Qun He, Jin-Ye Li, Quan-Rong Pan and Jie-Yin Deng

    Citation: Virology Journal 2013 10:162

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