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Hepatitis viruses

Section Editor: Alan McLachlan, University of Illinois at Chicago, USA 
Deputy Section Editor: Susan Uprichard, Loyola University Medical Center​​​​​​​, USA 

The Hepatitis viruses section of Virology Journal includes studies relating to all aspects of hepatitis A, B C, D and E virus research including research discoveries addressing both basic and medical aspects of the biology of these human pathogens. Basic research topics of interest include all aspects of the viral life cycle (e.g. viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress) and viral-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants.

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  1. Content type: Research

    Hepatitis B virus (HBV) surface antigen (HBsAg) screening in blood banks reduced the risk of HBV transmission through transfusion. However, the detection of occult HBV infection among blood donors is imperativ...

    Authors: Wilson Alfredo Rios-Ocampo, Fabián Cortes-Mancera, Juan Camilo Olarte, Angela Soto and Maria-Cristina Navas

    Citation: Virology Journal 2014 11:206

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  2. Content type: Research

    Hepatitis C virus (HCV) is a public health problem with almost 185 million people estimated to be infected worldwide and is one of the leading causes of hepatocellular carcinoma. Currently, there is no vaccine...

    Authors: Maemu P Gededzha, M Jeffrey Mphahlele and Selokela G Selabe

    Citation: Virology Journal 2014 11:187

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  3. Content type: Research

    The antiviral therapy of chronic hepatitis B virus (HBV) infection pursues the dual goals, virological response (undetectable serum HBV DNA) and hepatitis B e antigen (HBeAg) serological response (serum HBeAg ...

    Authors: Hui Y Yang, Nai Q Zheng, Dong M Li, Lin Gu and Xiao M Peng

    Citation: Virology Journal 2014 11:165

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  4. Content type: Research

    Hepatitis E is a disease of major public-health concern mainly in developing countries. Although molecular and sero-epidemiological investigations of HEV have been performed in many provinces in China, the epi...

    Authors: Xianghua Shu, Xinhui Duan, Chunlian Song, Jintao Li, Lei Jiang, Gefen Yin and Wengui Li

    Citation: Virology Journal 2014 11:162

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  5. Content type: Methodology

    Substitutions of amino acid (aa) 70 in the core region of hepatitis C virus genotype 1b (HCV 1b) are a predictor of the non-virological response to pegylated interferon plus ribavirin (PEG-IFN/RBV) therapy. Th...

    Authors: Zhongjie Hu, Ying Liu, Lixia Qiu, Zuopeng Fan, Wei Nie, Shan Liang and Ronghua Jin

    Citation: Virology Journal 2014 11:148

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  6. Content type: Research

    Aberrant DNA methylation profiles are a characteristic feature of almost all types of cancers including hepatocellular carcinoma (HCC) and play an important role in carcinogenesis. In spite of the accumulating...

    Authors: Muhammad Umer, Sohail Asif Qureshi, Zahid Yasin Hashmi, Asif Raza, Janbaz Ahmad, Moazur Rahman and Mazhar Iqbal

    Citation: Virology Journal 2014 11:117

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  7. Content type: Research

    Hepatitis B (HB) is an important disease worldwide. Almost 350 million people are positive for Hepatitis B virus surface antigen (HBsAg), and one-third of them live in China. According to a nation-wide serosur...

    Authors: Xiaoming Chen, Jie Gao, Zhaohua Ji, Weilu Zhang, Lei Zhang, Rui Xu, Jingxia Zhang, Fei Li, Shi Li, Shijie Hu, Lei Shang, ZhongJun Shao and Yongping Yan

    Citation: Virology Journal 2014 11:101

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  8. Content type: Research

    Torque Teno Virus (TTV) is a DNA virus with high rate of prevalence globally. Since its discovery in 1997, several studies have questioned the role of this virus in causing disease. However, it still remains a...

    Authors: Dhananjay Singh Mankotia and Mohammad Irshad

    Citation: Virology Journal 2014 11:96

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  9. Content type: Research

    Study C210 was a Phase IIa, exploratory trial to assess the activity of telaprevir on hepatitis C virus (HCV) early viral kinetics in treatment-naïve patients infected with genotype 4 (G4) HCV.

    Authors: Sandra De Meyer, Anne Ghys, Inge Dierynck, Maria Beumont, Donghan Luo and Gaston Picchio

    Citation: Virology Journal 2014 11:93

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  10. Content type: Research

    Hepatitis C virus (HCV) is a human pathogen causing chronic liver disease in about 200 million people worldwide. However, HCV resistance to interferon treatment is one of the important clinical implications, s...

    Authors: Xinliang Mao, Xifang Li, Xinjun Mao, Zhiwen Huang, Chengcheng Zhang, Wenjun Zhang, Jianguo Wu and Gang Li

    Citation: Virology Journal 2014 11:86

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  11. Content type: Short report

    Hepatitis E Virus (HEV) infection has a poor prognosis among pregnant women from high endemic countries. HEV-prevalence and incidence among pregnant women is unknown in high-income countries such as France. Th...

    Authors: Christophe Renou, Vincent Gobert, Christophe Locher, Abdelouahab Moumen, Oumar Timbely, Janine Savary and Anne-Marie Roque-Afonso

    Citation: Virology Journal 2014 11:68

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  12. Content type: Review

    Currently, there is no consensus on the efficacy and resistance of de novo combination therapy versus monotherapy for treatment naive patients of chronic hepatitis B (CHB).

    Authors: Fen Liu, Xiwei Wang, Fang Wei, Huaidong Hu, Dazhi Zhang, Peng Hu and Hong Ren

    Citation: Virology Journal 2014 11:59

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  13. Content type: Research

    Blood CXCR5+CD4+ T cells are defined as circulating T follicular helper (TFH) cells, which is required for effective humoral immunity. This study aimed to investigate the role of circulating TFH cells in patie...

    Authors: Ting-Ting Hu, Xiao-Fei Song, Yu Lei, Huai-Dong Hu, Hong Ren and Peng Hu

    Citation: Virology Journal 2014 11:54

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  14. Content type: Research

    The suppressor of cytokine signaling family (SOCS) is an important negative regulator in the JAK-STAT signaling pathway. This study was designed to explore the correlation between SOCS-1, 2 and 3, Hepatitis B ...

    Authors: Ling-yao Du, Yao-li Cui, En-qiang Chen, Xing Cheng, Li Liu and Hong Tang

    Citation: Virology Journal 2014 11:51

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  15. Content type: Research

    Hepatitis C virus is a persistent epidemiological problem, with an estimated 170 million individuals infected worldwide, and the leading cause of asymptomatic chronic infection, liver cirrhosis and hepatocellu...

    Authors: Roxana-Delia Trimbitas, Fatima Zahra Serghini, Fatiha Lazaar, Warda Baha, Abderrahim Foullous, Mohammed Essalhi, Abdelouahed El Malki, Abdelkrim Meziane Bellefquih and Abdelouaheb Bennani

    Citation: Virology Journal 2014 11:43

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  16. Content type: Research

    Currently, sharing of drug paraphernalia is the main form of HCV transmission worldwide. In South America, consistent findings indicate that shared sniffing equipment is an important factor in the spread of HC...

    Authors: Aldemir B Oliveira-Filho, Leila Sawada, Laine C Pinto, Daiane Locks, Santana L Bahia, JairoA A Castro, Renata B Hermes, Igor Brasil-Costa, CarlosE M Amaral and José Alexandre R Lemos

    Citation: Virology Journal 2014 11:38

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  17. Content type: Research

    Hepatitis B virus (HBV) transcription and replication are essentially restricted to hepatocytes. Based on the HBV enhancer and promoter complex that links hepatic glucose metabolism to its transcription and re...

    Authors: Xiaohui Tian, Fei Zhao, Weihua Sun, Xiaoguang Zhi, Zhikui Cheng, Ming Zhou and Kanghong Hu

    Citation: Virology Journal 2014 11:30

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  18. Content type: Short report

    Hepatitis C virus (HCV) is highly infectious pathogen which is responsible for causing Hepatitis around 200 million individuals worldwide. In Pakistan, 4.7% of HCV prevalence has been reported and HCV genotype...

    Authors: Suliman Qadir Afridi, Muhammad Muddassir Ali, Furqan Awan, Muhammad Nauman Zahid, Irfan Qadir Afridi, Sara Qadir Afridi and Tahir Yaqub

    Citation: Virology Journal 2014 11:24

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  19. Content type: Methodology

    Currently there is a significant risk of infection with hepatitis B virus (HBV) during blood transfusion in high epidemic area. This is due to the pre-seroconversion window period, immunovariant viral strains ...

    Authors: Alcione de Oliveira dos Santos, Luan Felipo Botelho Souza, Lourdes Maria Borzacov, Juan Miguel Villalobos-Salcedo and Deusilene Souza Vieira

    Citation: Virology Journal 2014 11:16

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  20. Content type: Case Report

    Co-infections with HBV (hepatitis B virus) occur in HIV (human immunodeficiency virus) patients frequently. It has been reported that an effective treatment of HIV can also lead to a suppression of HBV and to ...

    Authors: Rongjuan Pei, Sebastian Grund, Jens Verheyen, Stefan Esser, Xinwen Chen and Mengji Lu

    Citation: Virology Journal 2014 11:9

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  21. Content type: Research

    Direct-acting antiviral (DAA) agents target HCV proteins; some of these have already been approved for the treatment of HCV infection, while others are in development. However, selection of DAA-resistant viral...

    Authors: Stefania Paolucci, Loretta Fiorina, Bianca Mariani, Roberto Gulminetti, Stefano Novati, Giorgio Barbarini, Raffaele Bruno and Fausto Baldanti

    Citation: Virology Journal 2013 10:355

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  22. Content type: Research

    Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma and infects about 3% world population. Response to interferon therapy depends upon the genotype of the virus and factors...

    Authors: Atika Mansoor, Lubna Ali, Noor-ul Sabah, Asraf Hussain Hashmi, Mohammad Haroon Khan, Syed Ali Raza Kazmi, Nafees Ahmad, Saima Siddiqi and Khalid Mehmood Khan

    Citation: Virology Journal 2013 10:352

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  23. Content type: Research

    Although hepatitis C virus (HCV) is primarily hepatotropic, markers of HCV replication were detected in peripheral blood mononuclear cells (PBMC) as well as in ex vivo collected tissues and organs. Specific strai...

    Authors: Agnieszka Pawełczyk, Natalia Kubisa, Joanna Jabłońska, Iwona Bukowska-Ośko, Kamile Caraballo Cortes, Maria Fic, Tomasz Laskus and Marek Radkowski

    Citation: Virology Journal 2013 10:346

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  24. Content type: Case Report

    Using various methods, we analyzed the cause of death among weaned pigs from a pig farm in Hebei Province, China. All 300 piglets (100% fatality) were identified as moribund, with death occurring within 1 mont...

    Authors: Jingjing Mao, Yue Zhao, Ruiping She, Peng Xiao, Jijing Tian and Jian Chen

    Citation: Virology Journal 2013 10:341

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  25. Content type: Research

    An animal model for HBV that more closely approximates the disease in humans is needed. The tree shrew (Tupaia belangeri) is closely related to primates and susceptible to HBV. We previously established that neon...

    Authors: Ping Ruan, Chun Yang, Jianjia Su, Ji Cao, Chao Ou, Chengpiao Luo, Yanping Tang, Qi Wang, Fang Yang, Junlin Shi, Xiaoxu Lu, Linqun Zhu, Hong Qin, Wen Sun, Yuanzhi Lao and Yuan Li

    Citation: Virology Journal 2013 10:333

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  26. Content type: Research

    Continuous long-term treatment is recommended to reduce the hepatitis B virus (HBV) viral load. However, as a consequence, resistance mutations can emerge and be transmitted to other individuals. The polymeras...

    Authors: Nathalia Mantovani, Maira Cicero, Luiz Claudio Santana, Carla Silveira, Eliane Pereira do Carmo, Paulo Roberto Ferreira Abrão, Ricardo Sobhie Diaz, Marcos Montani Caseiro and Shirley Vasconcelos Komninakis

    Citation: Virology Journal 2013 10:320

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  27. Content type: Research

    Antiviral drug-resistant HBV mutants are complex and currently partly understood. This study was performed to analyze the profile of hepatitis B virus (HBV) resistance mutations against nucleos(t)ide analogues...

    Authors: Jun Lei, Ying Wang, Li-Li Wang, Shao-Jun Zhang, Wei Chen, Zhi-Gang Bai and Lv-Ye Xu

    Citation: Virology Journal 2013 10:313

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  28. Content type: Short report

    Hepatitis B virus (HBV) induces proliferation of human mesangial cells (HMCs), and extracellular matrix expression through the deposition of immune complexes in renal tissue. However, it is unclear whether HBV...

    Authors: Zongli Diao, Jiaxiang Ding, Chenghong Yin, Liyan Wang and Wenhu Liu

    Citation: Virology Journal 2013 10:300

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  29. Content type: Review

    The current standard of care (SOC) for hepatitis C virus (HCV) infection is the combination of pegylated interferon (PEG-IFN), Ribavirin and protease inhibitor for HCV genotype 1. Nevertheless, this treatment ...

    Authors: Muhammad Imran, Sobia Manzoor, Javed Ashraf, Madiha Khalid, Muqddas Tariq, Hafiza Madeha Khaliq and Sikandar Azam

    Citation: Virology Journal 2013 10:299

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  30. Content type: Research

    CTL escape mutations have been described during acute hepatitis C in patients who developed chronic disease later on. Our aim was to investigate the mutual relationship between HCV specific CD8+ T cells and ev...

    Authors: Axel Ulsenheimer, Gláucia Paranhos-Baccalà, Florence Komurian-Pradel, Bijan Raziorrouh, Peter Kurktschiev, Helmut M Diepolder, Reinhart Zachoval, Michael Spannagl, Maria-Christina Jung and Norbert H Gruener

    Citation: Virology Journal 2013 10:295

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  31. Content type: Research

    Selective pressure from either the immune response or the use of nucleoside analogs in antiviral therapy could be driving the emergence of HBV mutants. Because of the overlap of the open reading frame (ORF) S for...

    Authors: Mingshun Zhang, Guohong Ge, Yonglin Yang, Xubing Cai, Qiang Fu, Jie Cai and Zuhu Huang

    Citation: Virology Journal 2013 10:292

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  32. Content type: Research

    Majority of previous studies of pegylated interferon α-2a (PegIFNα-2a) forced on naïve chronic hepatitis B (CHB) patients, and the data of PegIFNα-2a in therapy of patients with prior exposure to nucleos(t)ide...

    Authors: Min Weng, Wei-Zheng Zeng, Xiao-Ling Wu, Yong Zhang, Ming-De Jiang, Zhao Wang, De-Jiang Zhou and Xuan He

    Citation: Virology Journal 2013 10:277

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  33. Content type: Research

    Hepatitis C virus (HCV) is a major cause of liver disease and a potential cause of substantial morbidity and mortality worldwide. The overall prevalence of HCV infection is 2%, representing 120 million people ...

    Authors: Tutik Sri Wahyuni, Lydia Tumewu, Adita Ayu Permanasari, Evhy Apriani, Myrna Adianti, Abdul Rahman, Aty Widyawaruyanti, Maria Inge Lusida, Achmad Fuad, Soetjipto, Nasronudin, Hiroyuki Fuchino, Nobuo Kawahara, Ikuo Shoji, Lin Deng, Chie Aoki…

    Citation: Virology Journal 2013 10:259

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  34. Content type: Research

    Hepatitis B virus (HBV) infection is a major global health problem. The infectious virion contains an inner “core particle”, which is made of 180 or 240 copies of core protein, alternatively known as hepatitis...

    Authors: Guangyu Xu, Chengguo Wei, Yuqi Guo, Chao Zhang, Nan Zhang and Guoqing Wang

    Citation: Virology Journal 2013 10:256

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  35. Content type: Review

    The disproportionate imbalance between the systemic manifestation of reactive oxygen species and body’s ability to detoxify the reactive intermediates is referred to as oxidative stress. Several biological pro...

    Authors: Usman Zafar Paracha, Kaneez Fatima, Mohammad Alqahtani, Adeel Chaudhary, Adel Abuzenadah, Ghazi Damanhouri and Ishtiaq Qadri

    Citation: Virology Journal 2013 10:251

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  36. Content type: Research

    Hepatitis B virus (HBV) genotype F (HBV/F) is considered to be indigenous to the Americas, but its emergence and spread in the continent remain unknown. Previously, only two HBV/F complete genome sequences fro...

    Authors: Francisco CA Mello, Oscar C Araujo, Barbara V Lago, Ana Rita C Motta-Castro, Marcia Terezinha B Moraes, Selma A Gomes, Gonzalo Bello and Natalia M Araujo

    Citation: Virology Journal 2013 10:236

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  37. Content type: Research

    Little is known about HBV-specific T-cell responses in chronic Hepatitis B patients (HBV) that are co-infected with Human immunodeficiency virus type 1 (HIV-1), especially those with normal alanine aminotransf...

    Authors: Xin Zhang, Hanqian Xing, Xia Feng, Haiping Zhang, Yi Wang and Huiping Yan

    Citation: Virology Journal 2013 10:232

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  38. Content type: Research

    It has been suggested that different hepatitis B virus (HBV) genotypes may have distinct virological characteristics that correlate with clinical outcomes during antiviral therapy and the natural course of inf...

    Authors: Lei Li, Hong Shen, Anyi Li, Zhenhua Zhang, Baoju Wang, Junzhong Wang, Xin Zheng, Jun Wu, Dongliang Yang, Mengji Lu and Jingjiao Song

    Citation: Virology Journal 2013 10:214

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  39. Content type: Research

    The prevalence of HCV infection has increased during recent years and the incidence reach 3% of the world's population, and in some countries like Egypt, may around 20%. The developments of effective and preve...

    Authors: Esmail M EL-Fakharany, Lourdes Sánchez, Hussein A Al-Mehdar and Elrashdy M Redwan

    Citation: Virology Journal 2013 10:199

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  40. Content type: Research

    To evaluate the efficacy and safety of Entecavir (ETV) plus adefovir (ADV) for chronic hepatitis B (CHB) patients after multiple nucleos(t)ide analogue (NAs) failure treatment.

    Authors: Xian-Hua Xu, Gai-Li Li, Yang Qin, Qiang Li, Fa-Qun He, Jin-Ye Li, Quan-Rong Pan and Jie-Yin Deng

    Citation: Virology Journal 2013 10:162

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