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Hepatitis viruses

Section Editor: Alan McLachlan, University of Illinois at Chicago, USA 
Deputy Section Editor: Susan Uprichard, Loyola University Medical Center​​​​​​​, USA 

The Hepatitis viruses section of Virology Journal includes studies relating to all aspects of hepatitis A, B C, D and E virus research including research discoveries addressing both basic and medical aspects of the biology of these human pathogens. Basic research topics of interest include all aspects of the viral life cycle (e.g. viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress) and viral-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants.

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  1. This study assessed the association of alanine-aminotransferase (ALT) and hepatitis C virus (HCV) RNA levels with pro-inflammatory and pro-fibrogenic cytokines and chemokines during acute HCV infection to prov...

    Authors: Behzad Hajarizadeh, François MJ Lamoury, Jordan J. Feld, Janaki Amin, Elizabeth Keoshkerian, Gail V. Matthews, Margaret Hellard, Gregory J. Dore, Andrew R. Lloyd, Jason Grebely and Tanya L. Applegate

    Citation: Virology Journal 2016 13:32

    Content type: Research

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  2. The mechanisms leading to virus-specific CD8+ T cell dysfuction in chronic hepatitis B virus (HBV) infection remain to be elucidated. Our study focused on the role of transcription factor T-bet in HBV infectio...

    Authors: Rongshan Fan, Yinghua Lan, Jiwang Chen, Yanxin Huang, Qin Yan, Lisheng Jiang, Shupeng Song and Yongguo Li

    Citation: Virology Journal 2016 13:14

    Content type: Research

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  3. In occult hepatitis B viral infection (OBI), the persistence of hepatitis B virus (HBV) DNA is associated with a lack of hepatitis B surface antigen (HBsAg). To assess the possible role of HBsAg immune escape ...

    Authors: Zhenhua Zhang, Ling Zhang, Yu Dai, Yafei Zhang, Jun Li and Xu Li

    Citation: Virology Journal 2016 13:10

    Content type: Research

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  4. There is no information on the long-term effects of peginterferon (PEG-IFN) alfa-2a therapy for chronic hepatitis B (CHB) in Japan. This double-blind, randomized trial investigated the efficacy of PEG-IFN ther...

    Authors: Keiichi Masaki, Fumitaka Suzuki, Tasuku Hara, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Satoshi Saitoh, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi and Hiromitsu Kumada

    Citation: Virology Journal 2015 12:225

    Content type: Research

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  5. Amino acid (aa) 70 substitution (R70Q/H) in the core protein of hepatitis C virus (HCV) genotype 1b has been shown to be one of the key factors in determining resistance for pegylated interferon-α plus ribavir...

    Authors: Zhongjie Hu, Ying Liu, Lixia Qiu, Zuopeng Fan, Wei Nie, Shan Liang and Ronghua Jin

    Citation: Virology Journal 2015 12:220

    Content type: Research

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  6. For many years, the standard of treatment for hepatitis C virus (HCV) infection was a combination of pegylated interferon alpha (Peg-IFN-α) and ribavirin for 24–48 weeks. This treatment regimen results in a su...

    Authors: Kattareeya Kumthip and Niwat Maneekarn

    Citation: Virology Journal 2015 12:217

    Content type: Review

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  7. Hepatitis B virus (HBV) DNA in serum of chronically infected patients declines by 3–4 log10 units at loss of HBe antigen (HBeAg) from serum. The mechanisms behind this decline, and the much smaller decline of sur...

    Authors: Simon B. Larsson, Sebastian Malmström, Charles Hannoun, Gunnar Norkrans and Magnus Lindh

    Citation: Virology Journal 2015 12:213

    Content type: Research

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  8. Viral hepatitis is a life-threatening liver disease that has become important public health issue in developing countries including Ethiopia. This study was undertaken to determine the seroprevalence of HBsAgs...

    Authors: Sefinew Molla, Abaineh Munshea and Endalkachew Nibret

    Citation: Virology Journal 2015 12:204

    Content type: Research

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  9. HBV X protein (HBX) is associated with cell apoptosis mediated by TNF-α related apoptosis inducing ligand (TRAIL), while the role of HBX on the expressions of TRAIL receptors death receptor 4 (DR4) and DR5 are...

    Authors: Fanyun Kong, Hongjuan You, Jinjin Zhao, Wen Liu, Lei Hu, Wenya Luo, Wei Hu, Renxian Tang and Kuiyang Zheng

    Citation: Virology Journal 2015 12:192

    Content type: Research

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  10. The detection of baseline resistance mutations to new direct-acting antivirals (DAAs) in HCV chronically infected treatment-naïve patients could be important for their management and outcome prevision. In this...

    Authors: Angela Costantino, Enea Spada, Michele Equestre, Roberto Bruni, Elena Tritarelli, Nicola Coppola, Caterina Sagnelli, Evangelista Sagnelli and Anna Rita Ciccaglione

    Citation: Virology Journal 2015 12:186

    Content type: Short report

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  11. The aim was to extract factors from virologic and biochemical profiles at baseline and 24 weeks of treatment to predict HBeAg seroconversion in patients treated with ETV.

    Authors: Fen Liu, Feng Zou, Xiwei Wang, Huaidong Hu, Peng Hu and Hong Ren

    Citation: Virology Journal 2015 12:179

    Content type: Research

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  12. In Colombia, cases of Hepatitis D virus (HDV) infection have been officially described since 1985 mainly in Amerindian population from Sierra Nevada de Santa Marta (North Caribbean Coast), Uraba (North West), ...

    Authors: Diana di Filippo Villa, Fabian Cortes-Mancera, Edra Payares, Neyla Montes, Fernando de la Hoz, Maria Patricia Arbelaez, Gonzalo Correa and Maria-Cristina Navas

    Citation: Virology Journal 2015 12:172

    Content type: Research

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  13. Major hydrophilic region in genomic HBV extending from aa99 to aa169, clustered with a highly conformational epitope, is critical to the antigenicity of hepatitis B surface antigen (HBsAg) and may affect the d...

    Authors: Rania Kishk, Nader Nemr, Abeer Elkady, Mohamed Mandour, Mohamed Aboelmagd, Nevene Ramsis, Mohamed Hassan, Nashaat Soliman, Sayuki Iijima, Shuko Murakami, Yasuhito Tanaka and Mostafa Ragheb

    Citation: Virology Journal 2015 12:153

    Content type: Research

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  14. Anti-hepatitis C virus (HCV) responses are often accompanied by an increase in alanine aminotransferase levels in HCV-infected patients, indicating that inflammatory responses are compromised by the virus. Add...

    Authors: Chao Fan, Ying Zhang, Yun Zhou, Bingjie Li, Yu He, Yonghong Guo and Zhansheng Jia

    Citation: Virology Journal 2015 12:147

    Content type: Research

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  15. The absent in melanoma 2 (AIM2), a cytosolic dsDNA inflammasome, can be activated by viral DNA to trigger caspase-1. Its role in immunopathology of chronic hepatitis B and C virus (HBV, HCV) infection is still...

    Authors: Yongtao Han, Ziping Chen, Ruiping Hou, Daojie Yan, Changhong Liu, Shijun Chen, Xiaobo Li and Wenjun Du

    Citation: Virology Journal 2015 12:129

    Content type: Research

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  16. Worldwide, Hepatitis C (HCV) infection has been increasingly recognized in HIV-positive men who have sex with men (MSM). The objective of this study was to characterize the transmission dynamics of acute HCV i...

    Authors: Denise P. Chan, Ada W. Lin, Ka Hing Wong, Ngai Sze Wong and Shui Shan Lee

    Citation: Virology Journal 2015 12:120

    Content type: Short report

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  17. Hepatitis C virus (HCV) genotype and subtype are related to disease progression and response to antiviral therapy. Current HCV genotype and subtype distribution data, especially for genotypes 3 and 6, are limi...

    Authors: Wei Ju, Song Yang, Shenghu Feng, Qi Wang, Shunai Liu, Huichun Xing, Wen Xie, Liying Zhu and Jun Cheng

    Citation: Virology Journal 2015 12:109

    Content type: Research

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  18. Mixed cryoglobulinemia (MC) in hepatitis C virus (HCV) infection is associated with abnormal immune responses mediated by T cells and B cells, while the relationships of different subsets of CD4 + T helper (Th...

    Authors: Fanyun Kong, Wei Zhang, Bo Feng, Henghui Zhang, Huiying Rao, Jianghua Wang, Xu Cong and Lai Wei

    Citation: Virology Journal 2015 12:100

    Content type: Research

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  19. Hepatitis C virus (HCV) genome contains two envelope proteins (E1 and E2) responsible for the virus entry into the cell. There is a substantial lack of sequences covering the full length of E1/E2 region for ge...

    Authors: Nehal Hussein, Abdel-Rahman N Zekri, Mohamed Abouelhoda, Hanaa M Alam El-din, Ahmed Abdelwahab Ghamry, Mahmoud A Amer, Ghada M sherif and Abeer A Bahnassy

    Citation: Virology Journal 2014 11:231

    Content type: Research

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  20. Hepatitis E virus (HEV) has been reported in the human population and pigs are a recognized reservoir for HEV and a possible source of HEV transmission to humans. Spray-dried porcine plasma (SDPP) is an ingred...

    Authors: Joan Pujols, Carmen Rodríguez, Nuria Navarro, Sonia Pina-Pedrero, Joy M Campbell, Joe Crenshaw and Javier Polo

    Citation: Virology Journal 2014 11:232

    Content type: Research

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  21. Hepatitis B virus (HBV) surface antigen (HBsAg) screening in blood banks reduced the risk of HBV transmission through transfusion. However, the detection of occult HBV infection among blood donors is imperativ...

    Authors: Wilson Alfredo Rios-Ocampo, Fabián Cortes-Mancera, Juan Camilo Olarte, Angela Soto and Maria-Cristina Navas

    Citation: Virology Journal 2014 11:206

    Content type: Research

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  22. Hepatitis C virus (HCV) is a public health problem with almost 185 million people estimated to be infected worldwide and is one of the leading causes of hepatocellular carcinoma. Currently, there is no vaccine...

    Authors: Maemu P Gededzha, M Jeffrey Mphahlele and Selokela G Selabe

    Citation: Virology Journal 2014 11:187

    Content type: Research

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  23. The antiviral therapy of chronic hepatitis B virus (HBV) infection pursues the dual goals, virological response (undetectable serum HBV DNA) and hepatitis B e antigen (HBeAg) serological response (serum HBeAg ...

    Authors: Hui Y Yang, Nai Q Zheng, Dong M Li, Lin Gu and Xiao M Peng

    Citation: Virology Journal 2014 11:165

    Content type: Research

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  24. Hepatitis E is a disease of major public-health concern mainly in developing countries. Although molecular and sero-epidemiological investigations of HEV have been performed in many provinces in China, the epi...

    Authors: Xianghua Shu, Xinhui Duan, Chunlian Song, Jintao Li, Lei Jiang, Gefen Yin and Wengui Li

    Citation: Virology Journal 2014 11:162

    Content type: Research

    Published on:

  25. Substitutions of amino acid (aa) 70 in the core region of hepatitis C virus genotype 1b (HCV 1b) are a predictor of the non-virological response to pegylated interferon plus ribavirin (PEG-IFN/RBV) therapy. Th...

    Authors: Zhongjie Hu, Ying Liu, Lixia Qiu, Zuopeng Fan, Wei Nie, Shan Liang and Ronghua Jin

    Citation: Virology Journal 2014 11:148

    Content type: Methodology

    Published on:

  26. Aberrant DNA methylation profiles are a characteristic feature of almost all types of cancers including hepatocellular carcinoma (HCC) and play an important role in carcinogenesis. In spite of the accumulating...

    Authors: Muhammad Umer, Sohail Asif Qureshi, Zahid Yasin Hashmi, Asif Raza, Janbaz Ahmad, Moazur Rahman and Mazhar Iqbal

    Citation: Virology Journal 2014 11:117

    Content type: Research

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  27. Hepatitis B (HB) is an important disease worldwide. Almost 350 million people are positive for Hepatitis B virus surface antigen (HBsAg), and one-third of them live in China. According to a nation-wide serosur...

    Authors: Xiaoming Chen, Jie Gao, Zhaohua Ji, Weilu Zhang, Lei Zhang, Rui Xu, Jingxia Zhang, Fei Li, Shi Li, Shijie Hu, Lei Shang, ZhongJun Shao and Yongping Yan

    Citation: Virology Journal 2014 11:101

    Content type: Research

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  28. Torque Teno Virus (TTV) is a DNA virus with high rate of prevalence globally. Since its discovery in 1997, several studies have questioned the role of this virus in causing disease. However, it still remains a...

    Authors: Dhananjay Singh Mankotia and Mohammad Irshad

    Citation: Virology Journal 2014 11:96

    Content type: Research

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  29. Study C210 was a Phase IIa, exploratory trial to assess the activity of telaprevir on hepatitis C virus (HCV) early viral kinetics in treatment-naïve patients infected with genotype 4 (G4) HCV.

    Authors: Sandra De Meyer, Anne Ghys, Inge Dierynck, Maria Beumont, Donghan Luo and Gaston Picchio

    Citation: Virology Journal 2014 11:93

    Content type: Research

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  30. Hepatitis C virus (HCV) is a human pathogen causing chronic liver disease in about 200 million people worldwide. However, HCV resistance to interferon treatment is one of the important clinical implications, s...

    Authors: Xinliang Mao, Xifang Li, Xinjun Mao, Zhiwen Huang, Chengcheng Zhang, Wenjun Zhang, Jianguo Wu and Gang Li

    Citation: Virology Journal 2014 11:86

    Content type: Research

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  31. Hepatitis E Virus (HEV) infection has a poor prognosis among pregnant women from high endemic countries. HEV-prevalence and incidence among pregnant women is unknown in high-income countries such as France. Th...

    Authors: Christophe Renou, Vincent Gobert, Christophe Locher, Abdelouahab Moumen, Oumar Timbely, Janine Savary and Anne-Marie Roque-Afonso

    Citation: Virology Journal 2014 11:68

    Content type: Short report

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  32. Currently, there is no consensus on the efficacy and resistance of de novo combination therapy versus monotherapy for treatment naive patients of chronic hepatitis B (CHB).

    Authors: Fen Liu, Xiwei Wang, Fang Wei, Huaidong Hu, Dazhi Zhang, Peng Hu and Hong Ren

    Citation: Virology Journal 2014 11:59

    Content type: Review

    Published on:

  33. Blood CXCR5+CD4+ T cells are defined as circulating T follicular helper (TFH) cells, which is required for effective humoral immunity. This study aimed to investigate the role of circulating TFH cells in patie...

    Authors: Ting-Ting Hu, Xiao-Fei Song, Yu Lei, Huai-Dong Hu, Hong Ren and Peng Hu

    Citation: Virology Journal 2014 11:54

    Content type: Research

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  34. The suppressor of cytokine signaling family (SOCS) is an important negative regulator in the JAK-STAT signaling pathway. This study was designed to explore the correlation between SOCS-1, 2 and 3, Hepatitis B ...

    Authors: Ling-yao Du, Yao-li Cui, En-qiang Chen, Xing Cheng, Li Liu and Hong Tang

    Citation: Virology Journal 2014 11:51

    Content type: Research

    Published on:

  35. Hepatitis C virus is a persistent epidemiological problem, with an estimated 170 million individuals infected worldwide, and the leading cause of asymptomatic chronic infection, liver cirrhosis and hepatocellu...

    Authors: Roxana-Delia Trimbitas, Fatima Zahra Serghini, Fatiha Lazaar, Warda Baha, Abderrahim Foullous, Mohammed Essalhi, Abdelouahed El Malki, Abdelkrim Meziane Bellefquih and Abdelouaheb Bennani

    Citation: Virology Journal 2014 11:43

    Content type: Research

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  36. Currently, sharing of drug paraphernalia is the main form of HCV transmission worldwide. In South America, consistent findings indicate that shared sniffing equipment is an important factor in the spread of HC...

    Authors: Aldemir B Oliveira-Filho, Leila Sawada, Laine C Pinto, Daiane Locks, Santana L Bahia, JairoA A Castro, Renata B Hermes, Igor Brasil-Costa, CarlosE M Amaral and José Alexandre R Lemos

    Citation: Virology Journal 2014 11:38

    Content type: Research

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  37. Hepatitis B virus (HBV) transcription and replication are essentially restricted to hepatocytes. Based on the HBV enhancer and promoter complex that links hepatic glucose metabolism to its transcription and re...

    Authors: Xiaohui Tian, Fei Zhao, Weihua Sun, Xiaoguang Zhi, Zhikui Cheng, Ming Zhou and Kanghong Hu

    Citation: Virology Journal 2014 11:30

    Content type: Research

    Published on:

  38. Hepatitis C virus (HCV) is highly infectious pathogen which is responsible for causing Hepatitis around 200 million individuals worldwide. In Pakistan, 4.7% of HCV prevalence has been reported and HCV genotype...

    Authors: Suliman Qadir Afridi, Muhammad Muddassir Ali, Furqan Awan, Muhammad Nauman Zahid, Irfan Qadir Afridi, Sara Qadir Afridi and Tahir Yaqub

    Citation: Virology Journal 2014 11:24

    Content type: Short report

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  39. Currently there is a significant risk of infection with hepatitis B virus (HBV) during blood transfusion in high epidemic area. This is due to the pre-seroconversion window period, immunovariant viral strains ...

    Authors: Alcione de Oliveira dos Santos, Luan Felipo Botelho Souza, Lourdes Maria Borzacov, Juan Miguel Villalobos-Salcedo and Deusilene Souza Vieira

    Citation: Virology Journal 2014 11:16

    Content type: Methodology

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  40. Co-infections with HBV (hepatitis B virus) occur in HIV (human immunodeficiency virus) patients frequently. It has been reported that an effective treatment of HIV can also lead to a suppression of HBV and to ...

    Authors: Rongjuan Pei, Sebastian Grund, Jens Verheyen, Stefan Esser, Xinwen Chen and Mengji Lu

    Citation: Virology Journal 2014 11:9

    Content type: Case Report

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  41. Direct-acting antiviral (DAA) agents target HCV proteins; some of these have already been approved for the treatment of HCV infection, while others are in development. However, selection of DAA-resistant viral...

    Authors: Stefania Paolucci, Loretta Fiorina, Bianca Mariani, Roberto Gulminetti, Stefano Novati, Giorgio Barbarini, Raffaele Bruno and Fausto Baldanti

    Citation: Virology Journal 2013 10:355

    Content type: Research

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  42. Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma and infects about 3% world population. Response to interferon therapy depends upon the genotype of the virus and factors...

    Authors: Atika Mansoor, Lubna Ali, Noor-ul Sabah, Asraf Hussain Hashmi, Mohammad Haroon Khan, Syed Ali Raza Kazmi, Nafees Ahmad, Saima Siddiqi and Khalid Mehmood Khan

    Citation: Virology Journal 2013 10:352

    Content type: Research

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  43. Although hepatitis C virus (HCV) is primarily hepatotropic, markers of HCV replication were detected in peripheral blood mononuclear cells (PBMC) as well as in ex vivo collected tissues and organs. Specific strai...

    Authors: Agnieszka Pawełczyk, Natalia Kubisa, Joanna Jabłońska, Iwona Bukowska-Ośko, Kamile Caraballo Cortes, Maria Fic, Tomasz Laskus and Marek Radkowski

    Citation: Virology Journal 2013 10:346

    Content type: Research

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  44. Using various methods, we analyzed the cause of death among weaned pigs from a pig farm in Hebei Province, China. All 300 piglets (100% fatality) were identified as moribund, with death occurring within 1 mont...

    Authors: Jingjing Mao, Yue Zhao, Ruiping She, Peng Xiao, Jijing Tian and Jian Chen

    Citation: Virology Journal 2013 10:341

    Content type: Case Report

    Published on: