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Hepatitis viruses

Section Editor: Alan McLachlan, University of Illinois at Chicago, USA 
Deputy Section Editor: Susan Uprichard, Loyola University Medical Center​​​​​​​, USA 

The Hepatitis viruses section of Virology Journal includes studies relating to all aspects of hepatitis A, B C, D and E virus research including research discoveries addressing both basic and medical aspects of the biology of these human pathogens. Basic research topics of interest include all aspects of the viral life cycle (e.g. viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress) and viral-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants.

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  1. Infection with the hepatitis E virus (HEV) can cause acute hepatitis in endemic areas in immune-competent hosts, as well as chronic infection in immune-compromised subjects in non-endemic areas. Most studies a...

    Authors: Ananta Shrestha, Anurag Adhikari, Manjula Bhattarai, Ramanuj Rauniyar, Jose D. Debes, André Boonstra, Thupten K. Lama, Mamun Al Mahtab, Amna Subhan Butt, Sheikh Mohammad Fazle Akbar, Nirmal Aryal, Sapana Karn, Krishna Das Manandhar and Birendra Prasad Gupta
    Citation: Virology Journal 2017 14:228
    Content type: Research Published on:

  2. Hepatitis C virus (HCV) genotypes and subtypes are considered an important tool for epidemiological and clinical studies and valuable markers for disease progression and response to antiviral therapy. The aim ...

    Authors: Amen Bawazir, Fahad AlGusheri, Hoda Jradi, Mohammed AlBalwi and Abdel-Galil Abdel-Gader
    Citation: Virology Journal 2017 14:208
    Content type: Research Published on:

  3. Hydrodynamic injection (HI) of hepatitis B virus (HBV) mouse model is an useful tool for HBV related research in vivo. However, only 40% of C57/BL6 mice injected with 10 Î¼g HBV genome contained plasmid (pAAV-H...

    Authors: Lei Li, Sheng Li, Yun Zhou, Lu Yang, Di Zhou, Yan Yang, Mengji Lu, Dongliang Yang and Jingjiao Song
    Citation: Virology Journal 2017 14:205
    Content type: Research Published on:

  4. The pathogenesis of acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is not well understood. The aim of this study was to investigate whether there is an association between HBV polymerase (P...

    Authors: Shan Gao, Shivali S. Joshi, Carla Osiowy, Y. Chen, Carla S. Coffin and Z-P. Duan
    Citation: Virology Journal 2017 14:203
    Content type: Research Published on:

  5. Occult hepatitis B infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the serum and/or liver in HBsAg-negative individuals. OBI is associated with the risk of viral transmission, espe...

    Authors: Yan Mardian, Yoshihiko Yano, Widya Wasityastuti, Neneng Ratnasari, Yujiao Liang, Wahyu Aristyaning Putri, Teguh Triyono and Yoshitake Hayashi
    Citation: Virology Journal 2017 14:201
    Content type: Research Published on:

  6. Seroprevalence of hepatitis C in Khyber Pakhtunkhwa province of Pakistan was determined by screening blood samples of expectant mothers seeking antenatal care in gynecological units of district hospitals. The ...

    Authors: Zobia Afsheen, Bashir Ahmad and Shumaila Bashir
    Citation: Virology Journal 2017 14:195
    Content type: Research Published on:

  7. Hepatitis B virus (HBV) infection is a serious public health problem leading to cirrhosis and hepatocellular carcinoma. As the clinical utility of current therapies is limited, the development of new therapeut...

    Authors: Huifang Li, Junru Li, Yuan Tang, Lin Lin, Zhanglian Xie, Jia Zhou, Liyun Zhang, Xiaoyong Zhang, Xiaoshan Zhao, Zhengliang Chen and Daming Zuo
    Citation: Virology Journal 2017 14:178
    Content type: Research Published on:

  8. There are an estimated 400 million chronic carriers of HBV worldwide; between 15 and 20 million have serological evidence of exposure to HDV. Traditionally, regions with high rates of endemicity are central an...

    Authors: Luan Felipo Botelho-Souza, Mariana Pinheiro Alves Vasconcelos, Alcione de Oliveira dos Santos, Juan Miguel Villalobos Salcedo and Deusilene Souza Vieira
    Citation: Virology Journal 2017 14:177
    Content type: Review Published on:

  10. Direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) treatment are tolerable and highly effective in a shorter period of time than before. However, resistance-associated variants (RAVs) can affect the...

    Authors: Jung Hwan Yu, Jung Il Lee, Kwan Sik Lee and Ja Kyung Kim
    Citation: Virology Journal 2017 14:164
    Content type: Research Published on:

  11. The existing literature about HCV association with, and replication in mosquitoes is extremely poor. To fill this gap, we performed cellular investigations aimed at exploring (i) the capacity of HCV E1E2 glyco...

    Authors: Catherine Fallecker, Alban Caporossi, Yassine Rechoum, Frederic Garzoni, Sylvie Larrat, Olivier François, Pascal Fender, Patrice Morand, Imre Berger, Marie-Anne Petit and Emmanuel Drouet
    Citation: Virology Journal 2017 14:161
    Content type: Research Published on:

  12. Hepatitis C virus (HCV) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and Hepatocellular Carcinoma (HCC). This study aimed to determine the prevalence of HCV gen...

    Authors: Nausheen Nazir, Muhammad Rasul Jan, Amjad Ali, Muhammad Asif, Muhammad Idrees, Mohammad Nisar, Muhammad Zahoor and Naser M. Abd El-Salam
    Citation: Virology Journal 2017 14:160
    Content type: Research Published on:

  13. Chronic hepatitis B virus (HBV) infection remains an important public health issue. A20, a ubiquitin-editing protein encoded by tumor necrosis factor alpha-inducible protein 3 (TNFAIP3) gene, is complicated in HB...

    Authors: Na Li, Ying Shi, Pingping Zhang, Jiao Sang, Fang Li, Huan Deng, Yi Lv, Qunying Han and Zhengwen Liu
    Citation: Virology Journal 2017 14:148
    Content type: Research Published on:

  14. Because of shared modes of transmission, patients with hepatitis C virus (HCV) infection are often co-infected with other types of hepatitis viruses and/or HIV. We studied HCV viral load and its genotype patte...

    Authors: Marzieh Jamalidoust, Mandana Namayandeh, Mohsen Moghadami and Mazyar Ziyaeyan
    Citation: Virology Journal 2017 14:127
    Content type: Research Published on:

  15. The major resistance-associated substitution for sofosbuvir (S282T) in HCV NS5B causes severe viral fitness costs and rapidly reverts back to prototype in the absence of selection pressure. Accordingly, resist...

    Authors: Andreas Walker, Sandra Filke, Nadine Lübke, Martin Obermeier, Rolf Kaiser, Dieter Häussinger, Jörg Timm and Hans H. Bock
    Citation: Virology Journal 2017 14:106
    Content type: Case report Published on:

  16. In study TMC647055HPC2001, a 3-direct-acting-antiviral (DAA) regimen combining NS3/4A protease inhibitor simeprevir (SMV), non-nucleoside NS5B inhibitor TMC647055/ritonavir (RTV) and NS5A inhibitor JNJ-5691484...

    Authors: Leen Vijgen, Kim Thys, An Vandebosch, Pieter Van Remoortere, René Verloes and Sandra De Meyer
    Citation: Virology Journal 2017 14:101
    Content type: Research Published on:

  18. Quantification Hepatitis B virus (HBV) DNA plays a critical role in the management of chronic HBV infections. However, HBV is a DNA virus with high levels of genetic variation, and drug-resistant mutations hav...

    Authors: Chao Liu, Le Chang, Tingting Jia, Fei Guo, Lu Zhang, Huimin Ji, Junpeng Zhao and Lunan Wang
    Citation: Virology Journal 2017 14:94
    Content type: Research Published on:

  19. Around 170–200 million individuals have hepatitis C virus (HCV), which represents ~ 3% of the world population, including ~ 3–5 million people in the USA. According to the WHO regional office in the Middle Eas...

    Authors: Mostafa H. Elberry, Noureldien H. E. Darwish and Shaker A. Mousa
    Citation: Virology Journal 2017 14:88
    Content type: Review Published on:

  20. Chronic hepatitis C virus (HCV) infection is an important cause of hepatocellular carcinoma (HCC). Epithelial to mesenchymal transition (EMT) is a key process associated with tumor metastasis and poor prognosi...

    Authors: Bicheng Hu, Shenggao Xie, Yuqian Hu, Wen Chen, Xiaofan Chen, Yi Zheng and Xinxing Wu
    Citation: Virology Journal 2017 14:83
    Content type: Research Published on:

  21. Hepatitis B virus (HBV) is the leading cause of liver cirrhosis and hepatocellular carcinoma in Asia and Africa. Existing antivirals cannot cure HBV or eliminate risk of hepatocellular carcinoma. Glucose-regul...

    Authors: Nai Q. Zheng, Zi H. Zheng, Hai X. Xu, Ming X. Huang and Xiao M. Peng
    Citation: Virology Journal 2017 14:77
    Content type: Research Published on:

  22. The amino acid substitution at position 181 of the Hepatitis B virus (HBV) polymerase is a multi-drug resistance affecting both the L-nucleoside and acyclic phosphonate nucleotide groups. Data is limited on th...

    Authors: Ping Li, Jiabao Geng, Wei Li, Xiaobing Xu, Xin Zhang, Wenkai Zheng, Yuecheng Yu, Zhiguo Yang and Maorong Wang
    Citation: Virology Journal 2017 14:68
    Content type: Research Published on:

  23. The Aptima HCV Quant Dx assay (Aptima assay) is a fully automated quantitative assay on the Panther® system. This assay is intended for confirmation of diagnosis and monitoring of HCV RNA in plasma and serum s...

    Authors: A. Worlock, D. Blair, M. Hunsicker, T. Le-Nguyen, C. Motta, C. Nguyen, E. Papachristou, J. Pham, A. Williams, M. Vi, B. Vinluan and A. Hatzakis
    Citation: Virology Journal 2017 14:66
    Content type: Methodology Published on:

  24. Chronic HCV Patients taking PEG-IFN-α/R from different ethnic groups have different probabilities of reaching a sustained viral response (SVR). There are many influence factors, such as HCV genotype, IL-28B si...

    Authors: Yanhua Li, Jiuping Wang, Juan Wang, Yunfeng Xiao, Bin Xu, Hongwei Li, Liu Yang, Xiaoke Hao and Yueyun Ma
    Citation: Virology Journal 2017 14:62
    Content type: Research Published on:

  25. Controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis B virus (HBV) infection. Thus, the aim of study was to analyze the changes in renal functio...

    Authors: Ye Zhang, Wei-Lu Zhang, Xiao-Wen Pang, Lin-Xu Wang, Xin Wei, Chang-Xing Huang, Xue-Fan Bai, Shuai Han, Lin-Na Liu and Jian-Qi Lian
    Citation: Virology Journal 2017 14:49
    Content type: Research Published on:

  28. In Ethiopia, there is lack of data on the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immune deficiency virus (HIV) infections in adult population at community level. This study ai...

    Authors: Bayeh Abera, Yesuf Adem, Mulat Yimer, Wondemagegn Mulu, Yohannes Zenebe and Zewdie Mekonnen
    Citation: Virology Journal 2017 14:21
    Content type: Research Published on:

  29. This study aimed to evaluate the predictive values of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) levels in 171 Chinese patients with chronic hepatitis B who received a 48-week course...

    Authors: Song Yang, Huichun Xing, Yuming Wang, Jinlin Hou, Duande Luo, Qing Xie, Qin Ning, Hong Ren, Huiguo Ding, Jifang Sheng, Lai Wei, Shijun Chen, Xiaoling Fan, Wenxiang Huang, Chen Pan, Zhiliang Gao…
    Citation: Virology Journal 2016 13:180
    Content type: Research Published on:

  30. HBV and HIV share similar transmission routes. Concurrent infection with the two viruses usually results in more severe and progressive liver disease, and a higher incidence of cirrhosis, liver cancer and mort...

    Authors: Tshifhiwa Magoro, George Gachara, Lufuno Mavhandu, Emmaculate Lum, Helen K. Kimbi, Roland N. Ndip and Pascal Bessong
    Citation: Virology Journal 2016 13:178
    Content type: Research Published on:

  32. The Centers for Disease Control and Prevention (CDC) issued an update on hepatitis C virus (HCV) testing approach, in which it omitted the use of recombinant immunoblot assay (RIBA) in the diagnostic algorithm...

    Authors: Mona Rafik, Salwa Bakr, Dina Soliman, Nesrine Mohammed, Dina Ragab, Walid Abd ElHady and Nancy Samir
    Citation: Virology Journal 2016 13:116
    Content type: Research Published on:

  33. The prognosis of liver failure depends greatly on the underlying cause, and there were few data about the prognosis, etiologies or trigger factors of liver failure in China based on long-term and large samples...

    Authors: Gui-Juan Xie, Hui-Yan Zhang, Qing Chen, Hui-Min Liu, Jian-Ping You, Sha Yang, Qing Mao and Xu-Qing Zhang
    Citation: Virology Journal 2016 13:89
    Content type: Research Published on:

  35. Hepatitis B virus (HBV) transmission through blood transfusion is reduced by screening for hepatitis B surface antigen (HBsAg). However this method cannot detect the presence of occult hepatitis B virus infect...

    Authors: Amadin A. Olotu, Adesola O. Oyelese, Lateef Salawu, Rosemary A. Audu, Azuka P. Okwuraiwe and Aaron O. Aboderin
    Citation: Virology Journal 2016 13:76
    Content type: Research Published on:

  36. HIV-HCV co-infection is associated with accelerated progression to hepatic fibrosis, cirrhosis and hepatocellular carcinoma than HCV mono-infection. The contribution of innate immunity during HIV-HCV co-infect...

    Authors: Suvercha Bhardwaj, Fareed Ahmad, Heiner Wedemeyer, Marcus Cornberg, Julian Schulze zur Wiesch, Jan van Lunzen, Shiv K. Sarin, Reinhold E. Schmidt and Dirk Meyer-Olson
    Citation: Virology Journal 2016 13:67
    Content type: Research Published on:

  37. To assess the potential effects of telbivudine (LdT) and entecavir (ETV) on renal function in patients with chronic hepatitis B (CHB), we performed a meta-analysis of the relevant data available on these agent...

    Authors: Xiaolu Wu, Shaohang Cai, Zhandong Li, Caixia Zheng, Xiulan Xue, Jianyong Zeng and Jie Peng
    Citation: Virology Journal 2016 13:64
    Content type: Research Published on:

  38. Hepatitis B virus (HBV) and hepatitis D virus (HDV) infections are major public health problems in sub-Saharan Africa. Whereas it is known that HBV infection is endemic in Nigeria, there is only little data ab...

    Authors: Oluyinka Oladele Opaleye, Oluwatoyin Margaret Japhet, Olubusuyi Moses Adewumi, Ewean Chukwuma Omoruyi, Olusola Anuoluwapo Akanbi, Adeolu Sunday Oluremi, Bo Wang, Hoang van Tong, Thirumalaisamy P. Velavan and C.-Thomas Bock
    Citation: Virology Journal 2016 13:61
    Content type: Research Published on:

  39. Hepatitis B virus is one of the most important blood born viruses. Although the sensitivity of screening tests has been considerably increased, transmission may still occur due to window period or occult hepat...

    Authors: Gharib Karimi, Maryam Zadsar, Nasrin Vafaei, Zohreh Sharifi and Mohammad FalahTafti
    Citation: Virology Journal 2016 13:36
    Content type: Research Published on:

  40. This study assessed the association of alanine-aminotransferase (ALT) and hepatitis C virus (HCV) RNA levels with pro-inflammatory and pro-fibrogenic cytokines and chemokines during acute HCV infection to prov...

    Authors: Behzad Hajarizadeh, François MJ Lamoury, Jordan J. Feld, Janaki Amin, Elizabeth Keoshkerian, Gail V. Matthews, Margaret Hellard, Gregory J. Dore, Andrew R. Lloyd, Jason Grebely and Tanya L. Applegate
    Citation: Virology Journal 2016 13:32
    Content type: Research Published on:

  41. The mechanisms leading to virus-specific CD8+ T cell dysfuction in chronic hepatitis B virus (HBV) infection remain to be elucidated. Our study focused on the role of transcription factor T-bet in HBV infectio...

    Authors: Rongshan Fan, Yinghua Lan, Jiwang Chen, Yanxin Huang, Qin Yan, Lisheng Jiang, Shupeng Song and Yongguo Li
    Citation: Virology Journal 2016 13:14
    Content type: Research Published on:

  42. In occult hepatitis B viral infection (OBI), the persistence of hepatitis B virus (HBV) DNA is associated with a lack of hepatitis B surface antigen (HBsAg). To assess the possible role of HBsAg immune escape ...

    Authors: Zhenhua Zhang, Ling Zhang, Yu Dai, Yafei Zhang, Jun Li and Xu Li
    Citation: Virology Journal 2016 13:10
    Content type: Research Published on:

  43. There is no information on the long-term effects of peginterferon (PEG-IFN) alfa-2a therapy for chronic hepatitis B (CHB) in Japan. This double-blind, randomized trial investigated the efficacy of PEG-IFN ther...

    Authors: Keiichi Masaki, Fumitaka Suzuki, Tasuku Hara, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Satoshi Saitoh, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi and Hiromitsu Kumada
    Citation: Virology Journal 2015 12:225
    Content type: Research Published on:

  44. Amino acid (aa) 70 substitution (R70Q/H) in the core protein of hepatitis C virus (HCV) genotype 1b has been shown to be one of the key factors in determining resistance for pegylated interferon-α plus ribavir...

    Authors: Zhongjie Hu, Ying Liu, Lixia Qiu, Zuopeng Fan, Wei Nie, Shan Liang and Ronghua Jin
    Citation: Virology Journal 2015 12:220
    Content type: Research Published on:

  45. For many years, the standard of treatment for hepatitis C virus (HCV) infection was a combination of pegylated interferon alpha (Peg-IFN-α) and ribavirin for 24–48 weeks. This treatment regimen results in a su...

    Authors: Kattareeya Kumthip and Niwat Maneekarn
    Citation: Virology Journal 2015 12:217
    Content type: Review Published on:

  46. Hepatitis B virus (HBV) DNA in serum of chronically infected patients declines by 3–4 log10 units at loss of HBe antigen (HBeAg) from serum. The mechanisms behind this decline, and the much smaller decline of sur...

    Authors: Simon B. Larsson, Sebastian Malmström, Charles Hannoun, Gunnar Norkrans and Magnus Lindh
    Citation: Virology Journal 2015 12:213
    Content type: Research Published on:

  47. Viral hepatitis is a life-threatening liver disease that has become important public health issue in developing countries including Ethiopia. This study was undertaken to determine the seroprevalence of HBsAgs...

    Authors: Sefinew Molla, Abaineh Munshea and Endalkachew Nibret
    Citation: Virology Journal 2015 12:204
    Content type: Research Published on:

  48. HBV X protein (HBX) is associated with cell apoptosis mediated by TNF-α related apoptosis inducing ligand (TRAIL), while the role of HBX on the expressions of TRAIL receptors death receptor 4 (DR4) and DR5 are...

    Authors: Fanyun Kong, Hongjuan You, Jinjin Zhao, Wen Liu, Lei Hu, Wenya Luo, Wei Hu, Renxian Tang and Kuiyang Zheng
    Citation: Virology Journal 2015 12:192
    Content type: Research Published on:

  49. The detection of baseline resistance mutations to new direct-acting antivirals (DAAs) in HCV chronically infected treatment-naïve patients could be important for their management and outcome prevision. In this...

    Authors: Angela Costantino, Enea Spada, Michele Equestre, Roberto Bruni, Elena Tritarelli, Nicola Coppola, Caterina Sagnelli, Evangelista Sagnelli and Anna Rita Ciccaglione
    Citation: Virology Journal 2015 12:186
    Content type: Short report Published on:

  50. The aim was to extract factors from virologic and biochemical profiles at baseline and 24 weeks of treatment to predict HBeAg seroconversion in patients treated with ETV.

    Authors: Fen Liu, Feng Zou, Xiwei Wang, Huaidong Hu, Peng Hu and Hong Ren
    Citation: Virology Journal 2015 12:179
    Content type: Research Published on:
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  • ISSN: 1743-422X (electronic)

Virology Journal

ISSN: 1743-422X