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Hepatitis viruses

Section Editor: Alan McLachlan, University of Illinois at Chicago, USA 
Deputy Section Editor: Susan Uprichard, Loyola University Medical Center​​​​​​​, USA 

The Hepatitis viruses section of Virology Journal includes studies relating to all aspects of hepatitis A, B C, D and E virus research including research discoveries addressing both basic and medical aspects of the biology of these human pathogens. Basic research topics of interest include all aspects of the viral life cycle (e.g. viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress) and viral-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants.

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  1. Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of...

    Authors: Ana Carolina Gomes Jardim, Jacqueline Farinha Shimizu, Paula Rahal and Mark Harris

    Citation: Virology Journal 2018 15:34

    Content type: Review

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  2. Simeprevir is approved with pegylated interferon and ribavirin (PR) for chronic hepatitis C virus (HCV) genotype (GT) 1 and GT4 infection in the USA and the European Union.

    Authors: Fabien Zoulim, Christophe Moreno, Samuel S. Lee, Peter Buggisch, Andrzej Horban, Eric Lawitz, Chris Corbett, Oliver Lenz, Bart Fevery, Thierry Verbinnen, Umesh Shukla and Wolfgang Jessner

    Citation: Virology Journal 2018 15:26

    Content type: Research

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  3. Previous published studies have reported conflicting results of association between hepatitis B virus (HBV) infection and preeclampsia. There was no published data on HBV and preeclampsia in Africa including S...

    Authors: Mohamed A. Ahmed, Manal E. Sharif, Duria A. Rayis, Abubakr M. Nasr and Ishag Adam

    Citation: Virology Journal 2018 15:20

    Content type: Research

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  4. The treatment of hepatitis C virus (HCV) in HCV/human immunodeficiency virus (HIV) co-infected patients remains complex. This present meta-analysis evaluated the efficacy and safety of Sofosbuvir (SOF) for tre...

    Authors: Guotao Li, Ke Zang, Guoqiang Zhang, Danyan Zhu and Xiaozhao Deng

    Citation: Virology Journal 2018 15:19

    Content type: Research

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  5. An association between hepatitis C virus (HCV) and type 2 diabetes (T2D) is supported by numerous epidemiologic studies. We hypothesized that HCV could infect human pancreatic islet cells in vitro.

    Authors: Jason T. Blackard, Ling Kong, Angela Lombardi, Dirk Homann, Sara Salehi Hammerstad and Yaron Tomer

    Citation: Virology Journal 2017 14:237

    Content type: Research

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  6. It has been widely accepted that hepatitis B virus X protein (HBx) plays an important role in hepatocellular carcinoma (HCC). This study aimed to explore the function of long non-coding RNAs (lncRNAs) in the e...

    Authors: Yinji Jin, Di Wu, Weiwei Yang, Mingjiao Weng, Yafei Li, Xuefei Wang, Xiao Zhang, Xiaoming Jin and Tianzhen Wang

    Citation: Virology Journal 2017 14:238

    Content type: Research

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  7. Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV) therapy and clearance for a majority of patients, but are not available or effective for all patients. They risk developing HCV-induced...

    Authors: Sara M. Ø. Solbak, Eldar Abdurakhmanov, Anni Vedeler and U. Helena Danielson

    Citation: Virology Journal 2017 14:236

    Content type: Research

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  8. Recently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationshi...

    Authors: Peng Huang, Haozhi Fan, Ting Tian, Peiwen Liao, Jun Li, Rongbin Yu, Xueshan Xia, Yue Feng, Jie Wang, Yuan Liu, Yun Zhang and Ming Yue

    Citation: Virology Journal 2017 14:235

    Content type: Research

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  9. Infection with the hepatitis E virus (HEV) can cause acute hepatitis in endemic areas in immune-competent hosts, as well as chronic infection in immune-compromised subjects in non-endemic areas. Most studies a...

    Authors: Ananta Shrestha, Anurag Adhikari, Manjula Bhattarai, Ramanuj Rauniyar, Jose D. Debes, André Boonstra, Thupten K. Lama, Mamun Al Mahtab, Amna Subhan Butt, Sheikh Mohammad Fazle Akbar, Nirmal Aryal, Sapana Karn, Krishna Das Manandhar and Birendra Prasad Gupta

    Citation: Virology Journal 2017 14:228

    Content type: Research

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  10. Hepatitis C virus (HCV) genotypes and subtypes are considered an important tool for epidemiological and clinical studies and valuable markers for disease progression and response to antiviral therapy. The aim ...

    Authors: Amen Bawazir, Fahad AlGusheri, Hoda Jradi, Mohammed AlBalwi and Abdel-Galil Abdel-Gader

    Citation: Virology Journal 2017 14:208

    Content type: Research

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  11. Hydrodynamic injection (HI) of hepatitis B virus (HBV) mouse model is an useful tool for HBV related research in vivo. However, only 40% of C57/BL6 mice injected with 10 μg HBV genome contained plasmid (pAAV-H...

    Authors: Lei Li, Sheng Li, Yun Zhou, Lu Yang, Di Zhou, Yan Yang, Mengji Lu, Dongliang Yang and Jingjiao Song

    Citation: Virology Journal 2017 14:205

    Content type: Research

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  12. The pathogenesis of acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is not well understood. The aim of this study was to investigate whether there is an association between HBV polymerase (P...

    Authors: Shan Gao, Shivali S. Joshi, Carla Osiowy, Y. Chen, Carla S. Coffin and Z-P. Duan

    Citation: Virology Journal 2017 14:203

    Content type: Research

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  13. Occult hepatitis B infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the serum and/or liver in HBsAg-negative individuals. OBI is associated with the risk of viral transmission, espe...

    Authors: Yan Mardian, Yoshihiko Yano, Widya Wasityastuti, Neneng Ratnasari, Yujiao Liang, Wahyu Aristyaning Putri, Teguh Triyono and Yoshitake Hayashi

    Citation: Virology Journal 2017 14:201

    Content type: Research

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  14. Seroprevalence of hepatitis C in Khyber Pakhtunkhwa province of Pakistan was determined by screening blood samples of expectant mothers seeking antenatal care in gynecological units of district hospitals. The ...

    Authors: Zobia Afsheen, Bashir Ahmad and Shumaila Bashir

    Citation: Virology Journal 2017 14:195

    Content type: Research

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  15. Hepatitis B virus (HBV) infection is a serious public health problem leading to cirrhosis and hepatocellular carcinoma. As the clinical utility of current therapies is limited, the development of new therapeut...

    Authors: Huifang Li, Junru Li, Yuan Tang, Lin Lin, Zhanglian Xie, Jia Zhou, Liyun Zhang, Xiaoyong Zhang, Xiaoshan Zhao, Zhengliang Chen and Daming Zuo

    Citation: Virology Journal 2017 14:178

    Content type: Research

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  16. There are an estimated 400 million chronic carriers of HBV worldwide; between 15 and 20 million have serological evidence of exposure to HDV. Traditionally, regions with high rates of endemicity are central an...

    Authors: Luan Felipo Botelho-Souza, Mariana Pinheiro Alves Vasconcelos, Alcione de Oliveira dos Santos, Juan Miguel Villalobos Salcedo and Deusilene Souza Vieira

    Citation: Virology Journal 2017 14:177

    Content type: Review

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  17. Direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) treatment are tolerable and highly effective in a shorter period of time than before. However, resistance-associated variants (RAVs) can affect the...

    Authors: Jung Hwan Yu, Jung Il Lee, Kwan Sik Lee and Ja Kyung Kim

    Citation: Virology Journal 2017 14:164

    Content type: Research

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  18. The existing literature about HCV association with, and replication in mosquitoes is extremely poor. To fill this gap, we performed cellular investigations aimed at exploring (i) the capacity of HCV E1E2 glyco...

    Authors: Catherine Fallecker, Alban Caporossi, Yassine Rechoum, Frederic Garzoni, Sylvie Larrat, Olivier François, Pascal Fender, Patrice Morand, Imre Berger, Marie-Anne Petit and Emmanuel Drouet

    Citation: Virology Journal 2017 14:161

    Content type: Research

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  19. Hepatitis C virus (HCV) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and Hepatocellular Carcinoma (HCC). This study aimed to determine the prevalence of HCV gen...

    Authors: Nausheen Nazir, Muhammad Rasul Jan, Amjad Ali, Muhammad Asif, Muhammad Idrees, Mohammad Nisar, Muhammad Zahoor and Naser M. Abd El-Salam

    Citation: Virology Journal 2017 14:160

    Content type: Research

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  20. Chronic hepatitis B virus (HBV) infection remains an important public health issue. A20, a ubiquitin-editing protein encoded by tumor necrosis factor alpha-inducible protein 3 (TNFAIP3) gene, is complicated in HB...

    Authors: Na Li, Ying Shi, Pingping Zhang, Jiao Sang, Fang Li, Huan Deng, Yi Lv, Qunying Han and Zhengwen Liu

    Citation: Virology Journal 2017 14:148

    Content type: Research

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  21. Because of shared modes of transmission, patients with hepatitis C virus (HCV) infection are often co-infected with other types of hepatitis viruses and/or HIV. We studied HCV viral load and its genotype patte...

    Authors: Marzieh Jamalidoust, Mandana Namayandeh, Mohsen Moghadami and Mazyar Ziyaeyan

    Citation: Virology Journal 2017 14:127

    Content type: Research

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  22. The major resistance-associated substitution for sofosbuvir (S282T) in HCV NS5B causes severe viral fitness costs and rapidly reverts back to prototype in the absence of selection pressure. Accordingly, resist...

    Authors: Andreas Walker, Sandra Filke, Nadine Lübke, Martin Obermeier, Rolf Kaiser, Dieter Häussinger, Jörg Timm and Hans H. Bock

    Citation: Virology Journal 2017 14:106

    Content type: Case report

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  23. In study TMC647055HPC2001, a 3-direct-acting-antiviral (DAA) regimen combining NS3/4A protease inhibitor simeprevir (SMV), non-nucleoside NS5B inhibitor TMC647055/ritonavir (RTV) and NS5A inhibitor JNJ-5691484...

    Authors: Leen Vijgen, Kim Thys, An Vandebosch, Pieter Van Remoortere, René Verloes and Sandra De Meyer

    Citation: Virology Journal 2017 14:101

    Content type: Research

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  24. Quantification Hepatitis B virus (HBV) DNA plays a critical role in the management of chronic HBV infections. However, HBV is a DNA virus with high levels of genetic variation, and drug-resistant mutations hav...

    Authors: Chao Liu, Le Chang, Tingting Jia, Fei Guo, Lu Zhang, Huimin Ji, Junpeng Zhao and Lunan Wang

    Citation: Virology Journal 2017 14:94

    Content type: Research

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  25. Around 170–200 million individuals have hepatitis C virus (HCV), which represents ~ 3% of the world population, including ~ 3–5 million people in the USA. According to the WHO regional office in the Middle Eas...

    Authors: Mostafa H. Elberry, Noureldien H. E. Darwish and Shaker A. Mousa

    Citation: Virology Journal 2017 14:88

    Content type: Review

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  26. Chronic hepatitis C virus (HCV) infection is an important cause of hepatocellular carcinoma (HCC). Epithelial to mesenchymal transition (EMT) is a key process associated with tumor metastasis and poor prognosi...

    Authors: Bicheng Hu, Shenggao Xie, Yuqian Hu, Wen Chen, Xiaofan Chen, Yi Zheng and Xinxing Wu

    Citation: Virology Journal 2017 14:83

    Content type: Research

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  27. Hepatitis B virus (HBV) is the leading cause of liver cirrhosis and hepatocellular carcinoma in Asia and Africa. Existing antivirals cannot cure HBV or eliminate risk of hepatocellular carcinoma. Glucose-regul...

    Authors: Nai Q. Zheng, Zi H. Zheng, Hai X. Xu, Ming X. Huang and Xiao M. Peng

    Citation: Virology Journal 2017 14:77

    Content type: Research

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  28. The amino acid substitution at position 181 of the Hepatitis B virus (HBV) polymerase is a multi-drug resistance affecting both the L-nucleoside and acyclic phosphonate nucleotide groups. Data is limited on th...

    Authors: Ping Li, Jiabao Geng, Wei Li, Xiaobing Xu, Xin Zhang, Wenkai Zheng, Yuecheng Yu, Zhiguo Yang and Maorong Wang

    Citation: Virology Journal 2017 14:68

    Content type: Research

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  29. The Aptima HCV Quant Dx assay (Aptima assay) is a fully automated quantitative assay on the Panther® system. This assay is intended for confirmation of diagnosis and monitoring of HCV RNA in plasma and serum s...

    Authors: A. Worlock, D. Blair, M. Hunsicker, T. Le-Nguyen, C. Motta, C. Nguyen, E. Papachristou, J. Pham, A. Williams, M. Vi, B. Vinluan and A. Hatzakis

    Citation: Virology Journal 2017 14:66

    Content type: Methodology

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  30. Chronic HCV Patients taking PEG-IFN-α/R from different ethnic groups have different probabilities of reaching a sustained viral response (SVR). There are many influence factors, such as HCV genotype, IL-28B si...

    Authors: Yanhua Li, Jiuping Wang, Juan Wang, Yunfeng Xiao, Bin Xu, Hongwei Li, Liu Yang, Xiaoke Hao and Yueyun Ma

    Citation: Virology Journal 2017 14:62

    Content type: Research

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  31. Controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis B virus (HBV) infection. Thus, the aim of study was to analyze the changes in renal functio...

    Authors: Ye Zhang, Wei-Lu Zhang, Xiao-Wen Pang, Lin-Xu Wang, Xin Wei, Chang-Xing Huang, Xue-Fan Bai, Shuai Han, Lin-Na Liu and Jian-Qi Lian

    Citation: Virology Journal 2017 14:49

    Content type: Research

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  32. In Ethiopia, there is lack of data on the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immune deficiency virus (HIV) infections in adult population at community level. This study ai...

    Authors: Bayeh Abera, Yesuf Adem, Mulat Yimer, Wondemagegn Mulu, Yohannes Zenebe and Zewdie Mekonnen

    Citation: Virology Journal 2017 14:21

    Content type: Research

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  33. This study aimed to evaluate the predictive values of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) levels in 171 Chinese patients with chronic hepatitis B who received a 48-week course...

    Authors: Song Yang, Huichun Xing, Yuming Wang, Jinlin Hou, Duande Luo, Qing Xie, Qin Ning, Hong Ren, Huiguo Ding, Jifang Sheng, Lai Wei, Shijun Chen, Xiaoling Fan, Wenxiang Huang, Chen Pan, Zhiliang Gao…

    Citation: Virology Journal 2016 13:180

    Content type: Research

    Published on:

  34. HBV and HIV share similar transmission routes. Concurrent infection with the two viruses usually results in more severe and progressive liver disease, and a higher incidence of cirrhosis, liver cancer and mort...

    Authors: Tshifhiwa Magoro, George Gachara, Lufuno Mavhandu, Emmaculate Lum, Helen K. Kimbi, Roland N. Ndip and Pascal Bessong

    Citation: Virology Journal 2016 13:178

    Content type: Research

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  35. The Centers for Disease Control and Prevention (CDC) issued an update on hepatitis C virus (HCV) testing approach, in which it omitted the use of recombinant immunoblot assay (RIBA) in the diagnostic algorithm...

    Authors: Mona Rafik, Salwa Bakr, Dina Soliman, Nesrine Mohammed, Dina Ragab, Walid Abd ElHady and Nancy Samir

    Citation: Virology Journal 2016 13:116

    Content type: Research

    Published on:

  36. The prognosis of liver failure depends greatly on the underlying cause, and there were few data about the prognosis, etiologies or trigger factors of liver failure in China based on long-term and large samples...

    Authors: Gui-Juan Xie, Hui-Yan Zhang, Qing Chen, Hui-Min Liu, Jian-Ping You, Sha Yang, Qing Mao and Xu-Qing Zhang

    Citation: Virology Journal 2016 13:89

    Content type: Research

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  37. Hepatitis B virus (HBV) transmission through blood transfusion is reduced by screening for hepatitis B surface antigen (HBsAg). However this method cannot detect the presence of occult hepatitis B virus infect...

    Authors: Amadin A. Olotu, Adesola O. Oyelese, Lateef Salawu, Rosemary A. Audu, Azuka P. Okwuraiwe and Aaron O. Aboderin

    Citation: Virology Journal 2016 13:76

    Content type: Research

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  38. HIV-HCV co-infection is associated with accelerated progression to hepatic fibrosis, cirrhosis and hepatocellular carcinoma than HCV mono-infection. The contribution of innate immunity during HIV-HCV co-infect...

    Authors: Suvercha Bhardwaj, Fareed Ahmad, Heiner Wedemeyer, Marcus Cornberg, Julian Schulze zur Wiesch, Jan van Lunzen, Shiv K. Sarin, Reinhold E. Schmidt and Dirk Meyer-Olson

    Citation: Virology Journal 2016 13:67

    Content type: Research

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  39. To assess the potential effects of telbivudine (LdT) and entecavir (ETV) on renal function in patients with chronic hepatitis B (CHB), we performed a meta-analysis of the relevant data available on these agent...

    Authors: Xiaolu Wu, Shaohang Cai, Zhandong Li, Caixia Zheng, Xiulan Xue, Jianyong Zeng and Jie Peng

    Citation: Virology Journal 2016 13:64

    Content type: Research

    Published on:

  40. Hepatitis B virus (HBV) and hepatitis D virus (HDV) infections are major public health problems in sub-Saharan Africa. Whereas it is known that HBV infection is endemic in Nigeria, there is only little data ab...

    Authors: Oluyinka Oladele Opaleye, Oluwatoyin Margaret Japhet, Olubusuyi Moses Adewumi, Ewean Chukwuma Omoruyi, Olusola Anuoluwapo Akanbi, Adeolu Sunday Oluremi, Bo Wang, Hoang van Tong, Thirumalaisamy P. Velavan and C.-Thomas Bock

    Citation: Virology Journal 2016 13:61

    Content type: Research

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  41. Hepatitis B virus is one of the most important blood born viruses. Although the sensitivity of screening tests has been considerably increased, transmission may still occur due to window period or occult hepat...

    Authors: Gharib Karimi, Maryam Zadsar, Nasrin Vafaei, Zohreh Sharifi and Mohammad FalahTafti

    Citation: Virology Journal 2016 13:36

    Content type: Research

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  42. This study assessed the association of alanine-aminotransferase (ALT) and hepatitis C virus (HCV) RNA levels with pro-inflammatory and pro-fibrogenic cytokines and chemokines during acute HCV infection to prov...

    Authors: Behzad Hajarizadeh, François MJ Lamoury, Jordan J. Feld, Janaki Amin, Elizabeth Keoshkerian, Gail V. Matthews, Margaret Hellard, Gregory J. Dore, Andrew R. Lloyd, Jason Grebely and Tanya L. Applegate

    Citation: Virology Journal 2016 13:32

    Content type: Research

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  43. The mechanisms leading to virus-specific CD8+ T cell dysfuction in chronic hepatitis B virus (HBV) infection remain to be elucidated. Our study focused on the role of transcription factor T-bet in HBV infectio...

    Authors: Rongshan Fan, Yinghua Lan, Jiwang Chen, Yanxin Huang, Qin Yan, Lisheng Jiang, Shupeng Song and Yongguo Li

    Citation: Virology Journal 2016 13:14

    Content type: Research

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  44. In occult hepatitis B viral infection (OBI), the persistence of hepatitis B virus (HBV) DNA is associated with a lack of hepatitis B surface antigen (HBsAg). To assess the possible role of HBsAg immune escape ...

    Authors: Zhenhua Zhang, Ling Zhang, Yu Dai, Yafei Zhang, Jun Li and Xu Li

    Citation: Virology Journal 2016 13:10

    Content type: Research

    Published on: