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Hepatitis viruses

Section Editor: Alan McLachlan, University of Illinois at Chicago, USA 
Deputy Section Editor: Susan Uprichard, Loyola University Medical Center​​​​​​​, USA 

The Hepatitis viruses section of Virology Journal includes studies relating to all aspects of hepatitis A, B C, D and E virus research including research discoveries addressing both basic and medical aspects of the biology of these human pathogens. Basic research topics of interest include all aspects of the viral life cycle (e.g. viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress) and viral-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants.

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  1. Content type: Research

    Direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) treatment are tolerable and highly effective in a shorter period of time than before. However, resistance-associated variants (RAVs) can affect the...

    Authors: Jung Hwan Yu, Jung Il Lee, Kwan Sik Lee and Ja Kyung Kim

    Citation: Virology Journal 2017 14:164

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  2. Content type: Research

    The existing literature about HCV association with, and replication in mosquitoes is extremely poor. To fill this gap, we performed cellular investigations aimed at exploring (i) the capacity of HCV E1E2 glyco...

    Authors: Catherine Fallecker, Alban Caporossi, Yassine Rechoum, Frederic Garzoni, Sylvie Larrat, Olivier François, Pascal Fender, Patrice Morand, Imre Berger, Marie-Anne Petit and Emmanuel Drouet

    Citation: Virology Journal 2017 14:161

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  3. Content type: Research

    Hepatitis C virus (HCV) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and Hepatocellular Carcinoma (HCC). This study aimed to determine the prevalence of HCV gen...

    Authors: Nausheen Nazir, Muhammad Rasul Jan, Amjad Ali, Muhammad Asif, Muhammad Idrees, Mohammad Nisar, Muhammad Zahoor and Naser M. Abd El-Salam

    Citation: Virology Journal 2017 14:160

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  4. Content type: Research

    Chronic hepatitis B virus (HBV) infection remains an important public health issue. A20, a ubiquitin-editing protein encoded by tumor necrosis factor alpha-inducible protein 3 (TNFAIP3) gene, is complicated in HB...

    Authors: Na Li, Ying Shi, Pingping Zhang, Jiao Sang, Fang Li, Huan Deng, Yi Lv, Qunying Han and Zhengwen Liu

    Citation: Virology Journal 2017 14:148

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  5. Content type: Research

    Because of shared modes of transmission, patients with hepatitis C virus (HCV) infection are often co-infected with other types of hepatitis viruses and/or HIV. We studied HCV viral load and its genotype patte...

    Authors: Marzieh Jamalidoust, Mandana Namayandeh, Mohsen Moghadami and Mazyar Ziyaeyan

    Citation: Virology Journal 2017 14:127

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  6. Content type: Case report

    The major resistance-associated substitution for sofosbuvir (S282T) in HCV NS5B causes severe viral fitness costs and rapidly reverts back to prototype in the absence of selection pressure. Accordingly, resist...

    Authors: Andreas Walker, Sandra Filke, Nadine Lübke, Martin Obermeier, Rolf Kaiser, Dieter Häussinger, Jörg Timm and Hans H. Bock

    Citation: Virology Journal 2017 14:106

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  7. Content type: Research

    In study TMC647055HPC2001, a 3-direct-acting-antiviral (DAA) regimen combining NS3/4A protease inhibitor simeprevir (SMV), non-nucleoside NS5B inhibitor TMC647055/ritonavir (RTV) and NS5A inhibitor JNJ-5691484...

    Authors: Leen Vijgen, Kim Thys, An Vandebosch, Pieter Van Remoortere, René Verloes and Sandra De Meyer

    Citation: Virology Journal 2017 14:101

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  8. Content type: Research

    Quantification Hepatitis B virus (HBV) DNA plays a critical role in the management of chronic HBV infections. However, HBV is a DNA virus with high levels of genetic variation, and drug-resistant mutations hav...

    Authors: Chao Liu, Le Chang, Tingting Jia, Fei Guo, Lu Zhang, Huimin Ji, Junpeng Zhao and Lunan Wang

    Citation: Virology Journal 2017 14:94

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  9. Content type: Review

    Around 170–200 million individuals have hepatitis C virus (HCV), which represents ~ 3% of the world population, including ~ 3–5 million people in the USA. According to the WHO regional office in the Middle Eas...

    Authors: Mostafa H. Elberry, Noureldien H. E. Darwish and Shaker A. Mousa

    Citation: Virology Journal 2017 14:88

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  10. Content type: Research

    Chronic hepatitis C virus (HCV) infection is an important cause of hepatocellular carcinoma (HCC). Epithelial to mesenchymal transition (EMT) is a key process associated with tumor metastasis and poor prognosi...

    Authors: Bicheng Hu, Shenggao Xie, Yuqian Hu, Wen Chen, Xiaofan Chen, Yi Zheng and Xinxing Wu

    Citation: Virology Journal 2017 14:83

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  11. Content type: Research

    Hepatitis B virus (HBV) is the leading cause of liver cirrhosis and hepatocellular carcinoma in Asia and Africa. Existing antivirals cannot cure HBV or eliminate risk of hepatocellular carcinoma. Glucose-regul...

    Authors: Nai Q. Zheng, Zi H. Zheng, Hai X. Xu, Ming X. Huang and Xiao M. Peng

    Citation: Virology Journal 2017 14:77

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  12. Content type: Research

    The amino acid substitution at position 181 of the Hepatitis B virus (HBV) polymerase is a multi-drug resistance affecting both the L-nucleoside and acyclic phosphonate nucleotide groups. Data is limited on th...

    Authors: Ping Li, Jiabao Geng, Wei Li, Xiaobing Xu, Xin Zhang, Wenkai Zheng, Yuecheng Yu, Zhiguo Yang and Maorong Wang

    Citation: Virology Journal 2017 14:68

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  13. Content type: Methodology

    The Aptima HCV Quant Dx assay (Aptima assay) is a fully automated quantitative assay on the Panther® system. This assay is intended for confirmation of diagnosis and monitoring of HCV RNA in plasma and serum s...

    Authors: A. Worlock, D. Blair, M. Hunsicker, T. Le-Nguyen, C. Motta, C. Nguyen, E. Papachristou, J. Pham, A. Williams, M. Vi, B. Vinluan and A. Hatzakis

    Citation: Virology Journal 2017 14:66

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  14. Content type: Research

    Chronic HCV Patients taking PEG-IFN-α/R from different ethnic groups have different probabilities of reaching a sustained viral response (SVR). There are many influence factors, such as HCV genotype, IL-28B si...

    Authors: Yanhua Li, Jiuping Wang, Juan Wang, Yunfeng Xiao, Bin Xu, Hongwei Li, Liu Yang, Xiaoke Hao and Yueyun Ma

    Citation: Virology Journal 2017 14:62

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  15. Content type: Research

    Controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis B virus (HBV) infection. Thus, the aim of study was to analyze the changes in renal functio...

    Authors: Ye Zhang, Wei-Lu Zhang, Xiao-Wen Pang, Lin-Xu Wang, Xin Wei, Chang-Xing Huang, Xue-Fan Bai, Shuai Han, Lin-Na Liu and Jian-Qi Lian

    Citation: Virology Journal 2017 14:49

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  16. Content type: Research

    In Ethiopia, there is lack of data on the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immune deficiency virus (HIV) infections in adult population at community level. This study ai...

    Authors: Bayeh Abera, Yesuf Adem, Mulat Yimer, Wondemagegn Mulu, Yohannes Zenebe and Zewdie Mekonnen

    Citation: Virology Journal 2017 14:21

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  17. Content type: Research

    This study aimed to evaluate the predictive values of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) levels in 171 Chinese patients with chronic hepatitis B who received a 48-week course...

    Authors: Song Yang, Huichun Xing, Yuming Wang, Jinlin Hou, Duande Luo, Qing Xie, Qin Ning, Hong Ren, Huiguo Ding, Jifang Sheng, Lai Wei, Shijun Chen, Xiaoling Fan, Wenxiang Huang, Chen Pan, Zhiliang Gao…

    Citation: Virology Journal 2016 13:180

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  18. Content type: Research

    HBV and HIV share similar transmission routes. Concurrent infection with the two viruses usually results in more severe and progressive liver disease, and a higher incidence of cirrhosis, liver cancer and mort...

    Authors: Tshifhiwa Magoro, George Gachara, Lufuno Mavhandu, Emmaculate Lum, Helen K. Kimbi, Roland N. Ndip and Pascal Bessong

    Citation: Virology Journal 2016 13:178

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  19. Content type: Research

    The Centers for Disease Control and Prevention (CDC) issued an update on hepatitis C virus (HCV) testing approach, in which it omitted the use of recombinant immunoblot assay (RIBA) in the diagnostic algorithm...

    Authors: Mona Rafik, Salwa Bakr, Dina Soliman, Nesrine Mohammed, Dina Ragab, Walid Abd ElHady and Nancy Samir

    Citation: Virology Journal 2016 13:116

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  20. Content type: Research

    The prognosis of liver failure depends greatly on the underlying cause, and there were few data about the prognosis, etiologies or trigger factors of liver failure in China based on long-term and large samples...

    Authors: Gui-Juan Xie, Hui-Yan Zhang, Qing Chen, Hui-Min Liu, Jian-Ping You, Sha Yang, Qing Mao and Xu-Qing Zhang

    Citation: Virology Journal 2016 13:89

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  21. Content type: Research

    Hepatitis B virus (HBV) transmission through blood transfusion is reduced by screening for hepatitis B surface antigen (HBsAg). However this method cannot detect the presence of occult hepatitis B virus infect...

    Authors: Amadin A. Olotu, Adesola O. Oyelese, Lateef Salawu, Rosemary A. Audu, Azuka P. Okwuraiwe and Aaron O. Aboderin

    Citation: Virology Journal 2016 13:76

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  22. Content type: Research

    HIV-HCV co-infection is associated with accelerated progression to hepatic fibrosis, cirrhosis and hepatocellular carcinoma than HCV mono-infection. The contribution of innate immunity during HIV-HCV co-infect...

    Authors: Suvercha Bhardwaj, Fareed Ahmad, Heiner Wedemeyer, Marcus Cornberg, Julian Schulze zur Wiesch, Jan van Lunzen, Shiv K. Sarin, Reinhold E. Schmidt and Dirk Meyer-Olson

    Citation: Virology Journal 2016 13:67

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  23. Content type: Research

    To assess the potential effects of telbivudine (LdT) and entecavir (ETV) on renal function in patients with chronic hepatitis B (CHB), we performed a meta-analysis of the relevant data available on these agent...

    Authors: Xiaolu Wu, Shaohang Cai, Zhandong Li, Caixia Zheng, Xiulan Xue, Jianyong Zeng and Jie Peng

    Citation: Virology Journal 2016 13:64

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  24. Content type: Research

    Hepatitis B virus (HBV) and hepatitis D virus (HDV) infections are major public health problems in sub-Saharan Africa. Whereas it is known that HBV infection is endemic in Nigeria, there is only little data ab...

    Authors: Oluyinka Oladele Opaleye, Oluwatoyin Margaret Japhet, Olubusuyi Moses Adewumi, Ewean Chukwuma Omoruyi, Olusola Anuoluwapo Akanbi, Adeolu Sunday Oluremi, Bo Wang, Hoang van Tong, Thirumalaisamy P. Velavan and C.-Thomas Bock

    Citation: Virology Journal 2016 13:61

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  25. Content type: Research

    Hepatitis B virus is one of the most important blood born viruses. Although the sensitivity of screening tests has been considerably increased, transmission may still occur due to window period or occult hepat...

    Authors: Gharib Karimi, Maryam Zadsar, Nasrin Vafaei, Zohreh Sharifi and Mohammad FalahTafti

    Citation: Virology Journal 2016 13:36

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  26. Content type: Research

    This study assessed the association of alanine-aminotransferase (ALT) and hepatitis C virus (HCV) RNA levels with pro-inflammatory and pro-fibrogenic cytokines and chemokines during acute HCV infection to prov...

    Authors: Behzad Hajarizadeh, François MJ Lamoury, Jordan J. Feld, Janaki Amin, Elizabeth Keoshkerian, Gail V. Matthews, Margaret Hellard, Gregory J. Dore, Andrew R. Lloyd, Jason Grebely and Tanya L. Applegate

    Citation: Virology Journal 2016 13:32

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  27. Content type: Research

    The mechanisms leading to virus-specific CD8+ T cell dysfuction in chronic hepatitis B virus (HBV) infection remain to be elucidated. Our study focused on the role of transcription factor T-bet in HBV infectio...

    Authors: Rongshan Fan, Yinghua Lan, Jiwang Chen, Yanxin Huang, Qin Yan, Lisheng Jiang, Shupeng Song and Yongguo Li

    Citation: Virology Journal 2016 13:14

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  28. Content type: Research

    In occult hepatitis B viral infection (OBI), the persistence of hepatitis B virus (HBV) DNA is associated with a lack of hepatitis B surface antigen (HBsAg). To assess the possible role of HBsAg immune escape ...

    Authors: Zhenhua Zhang, Ling Zhang, Yu Dai, Yafei Zhang, Jun Li and Xu Li

    Citation: Virology Journal 2016 13:10

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  29. Content type: Research

    There is no information on the long-term effects of peginterferon (PEG-IFN) alfa-2a therapy for chronic hepatitis B (CHB) in Japan. This double-blind, randomized trial investigated the efficacy of PEG-IFN ther...

    Authors: Keiichi Masaki, Fumitaka Suzuki, Tasuku Hara, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Satoshi Saitoh, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi and Hiromitsu Kumada

    Citation: Virology Journal 2015 12:225

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  30. Content type: Research

    Amino acid (aa) 70 substitution (R70Q/H) in the core protein of hepatitis C virus (HCV) genotype 1b has been shown to be one of the key factors in determining resistance for pegylated interferon-α plus ribavir...

    Authors: Zhongjie Hu, Ying Liu, Lixia Qiu, Zuopeng Fan, Wei Nie, Shan Liang and Ronghua Jin

    Citation: Virology Journal 2015 12:220

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  31. Content type: Review

    For many years, the standard of treatment for hepatitis C virus (HCV) infection was a combination of pegylated interferon alpha (Peg-IFN-α) and ribavirin for 24–48 weeks. This treatment regimen results in a su...

    Authors: Kattareeya Kumthip and Niwat Maneekarn

    Citation: Virology Journal 2015 12:217

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  32. Content type: Research

    Hepatitis B virus (HBV) DNA in serum of chronically infected patients declines by 3–4 log10 units at loss of HBe antigen (HBeAg) from serum. The mechanisms behind this decline, and the much smaller decline of sur...

    Authors: Simon B. Larsson, Sebastian Malmström, Charles Hannoun, Gunnar Norkrans and Magnus Lindh

    Citation: Virology Journal 2015 12:213

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  33. Content type: Research

    Viral hepatitis is a life-threatening liver disease that has become important public health issue in developing countries including Ethiopia. This study was undertaken to determine the seroprevalence of HBsAgs...

    Authors: Sefinew Molla, Abaineh Munshea and Endalkachew Nibret

    Citation: Virology Journal 2015 12:204

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  34. Content type: Research

    HBV X protein (HBX) is associated with cell apoptosis mediated by TNF-α related apoptosis inducing ligand (TRAIL), while the role of HBX on the expressions of TRAIL receptors death receptor 4 (DR4) and DR5 are...

    Authors: Fanyun Kong, Hongjuan You, Jinjin Zhao, Wen Liu, Lei Hu, Wenya Luo, Wei Hu, Renxian Tang and Kuiyang Zheng

    Citation: Virology Journal 2015 12:192

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  35. Content type: Short report

    The detection of baseline resistance mutations to new direct-acting antivirals (DAAs) in HCV chronically infected treatment-naïve patients could be important for their management and outcome prevision. In this...

    Authors: Angela Costantino, Enea Spada, Michele Equestre, Roberto Bruni, Elena Tritarelli, Nicola Coppola, Caterina Sagnelli, Evangelista Sagnelli and Anna Rita Ciccaglione

    Citation: Virology Journal 2015 12:186

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  36. Content type: Research

    The aim was to extract factors from virologic and biochemical profiles at baseline and 24 weeks of treatment to predict HBeAg seroconversion in patients treated with ETV.

    Authors: Fen Liu, Feng Zou, Xiwei Wang, Huaidong Hu, Peng Hu and Hong Ren

    Citation: Virology Journal 2015 12:179

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  37. Content type: Research

    In Colombia, cases of Hepatitis D virus (HDV) infection have been officially described since 1985 mainly in Amerindian population from Sierra Nevada de Santa Marta (North Caribbean Coast), Uraba (North West), ...

    Authors: Diana di Filippo Villa, Fabian Cortes-Mancera, Edra Payares, Neyla Montes, Fernando de la Hoz, Maria Patricia Arbelaez, Gonzalo Correa and Maria-Cristina Navas

    Citation: Virology Journal 2015 12:172

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  38. Content type: Research

    Major hydrophilic region in genomic HBV extending from aa99 to aa169, clustered with a highly conformational epitope, is critical to the antigenicity of hepatitis B surface antigen (HBsAg) and may affect the d...

    Authors: Rania Kishk, Nader Nemr, Abeer Elkady, Mohamed Mandour, Mohamed Aboelmagd, Nevene Ramsis, Mohamed Hassan, Nashaat Soliman, Sayuki Iijima, Shuko Murakami, Yasuhito Tanaka and Mostafa Ragheb

    Citation: Virology Journal 2015 12:153

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  39. Content type: Research

    Anti-hepatitis C virus (HCV) responses are often accompanied by an increase in alanine aminotransferase levels in HCV-infected patients, indicating that inflammatory responses are compromised by the virus. Add...

    Authors: Chao Fan, Ying Zhang, Yun Zhou, Bingjie Li, Yu He, Yonghong Guo and Zhansheng Jia

    Citation: Virology Journal 2015 12:147

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  40. Content type: Research

    The absent in melanoma 2 (AIM2), a cytosolic dsDNA inflammasome, can be activated by viral DNA to trigger caspase-1. Its role in immunopathology of chronic hepatitis B and C virus (HBV, HCV) infection is still...

    Authors: Yongtao Han, Ziping Chen, Ruiping Hou, Daojie Yan, Changhong Liu, Shijun Chen, Xiaobo Li and Wenjun Du

    Citation: Virology Journal 2015 12:129

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  41. Content type: Short report

    Worldwide, Hepatitis C (HCV) infection has been increasingly recognized in HIV-positive men who have sex with men (MSM). The objective of this study was to characterize the transmission dynamics of acute HCV i...

    Authors: Denise P. Chan, Ada W. Lin, Ka Hing Wong, Ngai Sze Wong and Shui Shan Lee

    Citation: Virology Journal 2015 12:120

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  42. Content type: Research

    Hepatitis C virus (HCV) genotype and subtype are related to disease progression and response to antiviral therapy. Current HCV genotype and subtype distribution data, especially for genotypes 3 and 6, are limi...

    Authors: Wei Ju, Song Yang, Shenghu Feng, Qi Wang, Shunai Liu, Huichun Xing, Wen Xie, Liying Zhu and Jun Cheng

    Citation: Virology Journal 2015 12:109

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  43. Content type: Research

    Mixed cryoglobulinemia (MC) in hepatitis C virus (HCV) infection is associated with abnormal immune responses mediated by T cells and B cells, while the relationships of different subsets of CD4 + T helper (Th...

    Authors: Fanyun Kong, Wei Zhang, Bo Feng, Henghui Zhang, Huiying Rao, Jianghua Wang, Xu Cong and Lai Wei

    Citation: Virology Journal 2015 12:100

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  44. Content type: Research

    Hepatitis C virus (HCV) genome contains two envelope proteins (E1 and E2) responsible for the virus entry into the cell. There is a substantial lack of sequences covering the full length of E1/E2 region for ge...

    Authors: Nehal Hussein, Abdel-Rahman N Zekri, Mohamed Abouelhoda, Hanaa M Alam El-din, Ahmed Abdelwahab Ghamry, Mahmoud A Amer, Ghada M sherif and Abeer A Bahnassy

    Citation: Virology Journal 2014 11:231

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