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Hepatitis viruses

Section Editor: Alan McLachlan, University of Illinois at Chicago, USA 
Deputy Section Editor: Susan Uprichard, Loyola University Medical Center​​​​​​​, USA 

The Hepatitis viruses section of Virology Journal includes studies relating to all aspects of hepatitis A, B C, D and E virus research including research discoveries addressing both basic and medical aspects of the biology of these human pathogens. Basic research topics of interest include all aspects of the viral life cycle (e.g. viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress) and viral-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants.

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  1. Hepatitis E virus (HEV) generally causes self-limiting viral hepatitis. However, in pregnant women, HEV infection can be severe and has been associated with up to 30% mortality in the third trimester. Addition...

    Authors: Chunchen Wu, Xiaoxue Wu and Jianbo Xia
    Citation: Virology Journal 2020 17:73
  2. Hepatitis B virus (HBV) infection remains as one of the major public health problems in the world. Type I interferon (IFN) plays an essential role in antiviral defense by induced expression of a few hundred in...

    Authors: Yujia Li, Min Yao, Xiaoqiong Duan, Haiyan Ye, Shilin Li, Limin Chen, Chunhui Yang and Yongjun Chen
    Citation: Virology Journal 2020 17:47
  3. The prevalence of hepatitis C virus (HCV) infection is typically evaluated based on the current rate of positivity of anti-HCV antibody; however, HCV RNA positivity is considered the main criterion for antivir...

    Authors: Yurong Li, Lianrong Zhao, Nan Geng, Weijia Zhu, Hongbo Liu and Han Bai
    Citation: Virology Journal 2020 17:36
  4. Hepatitis C virus (HCV) infection is a public health issue for which an effective universal screening method is urgently needed. An oral anti-HCV test could provide a noninvasive and rapid screening strategy f...

    Authors: Lili Liu, Mingyuan Zhang, Lei Hang, Fei Kong, Hongqing Yan, Yumei Zhang, Xiangwei Feng, Yuanda Gao, Chang Wang, Heming Ma, Xu Liu, Mengru Zhan, Yu Pan, Hongqin Xu and Junqi Niu
    Citation: Virology Journal 2020 17:14
  5. Avian hepatitis E virus (aHEV) has been associated with hepatitis-splenomegaly syndrome (HSS) in chickens along with asymptomatic subclinical infection in many cases. So far, four genotypes have been described...

    Authors: Tahir Iqbal, Umer Rashid, Muhammad Idrees, Amber Afroz, Saleem Kamili and Michael A. Purdy
    Citation: Virology Journal 2019 16:142
  6. Human pegivirus (HPgV) is structurally similar to hepatitis C virus (HCV) and was discovered 20 years ago. Its distribution, natural history and exact rule of this viral group in human hosts remain unclear. Ou...

    Authors: Hany K. Soliman, Mohamed Abouelhoda, Mahmoud N. El Rouby, Ola S. Ahmed, G. Esmat, Zeinab K. Hassan, Mohammed M. Hafez, Dina Ahmed Mehaney, Manojkumar Selvaraju, Rania Kamal Darwish, Yehia A. Osman and Abdel-Rahman N. Zekri
    Citation: Virology Journal 2019 16:132
  7. Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) is a novel target and molecule in the negative regulation of immune homeostasis. The present study aimed to investigate the dynamic expression of TI...

    Authors: Yi Liu, Jia Jin, Jian Ji, Xi-Mei Gao and Yu-Chen Fan
    Citation: Virology Journal 2019 16:120
  8. Hepatitis B virus-related decompensated cirrhosis is difficult to cure but has a high readmission rate due to multiple complications. Our aim was to investigate the diagnostic potential value of plasma diamine...

    Authors: Feng-Cai Li, Yu-Chen Fan, Yue-Kai Li and Kai Wang
    Citation: Virology Journal 2019 16:115
  9. Current HCV treatments are genotype specific although potential pan-genotype treatments have recently been described. Therefore, genotyping is an essential tool for the therapeutic management of HCV infection ...

    Authors: Paul Alain Tagnouokam-Ngoupo, Marie Nicole Ngoufack, Sebastien Kenmoe, Simon Frédéric Lissock, Marie Amougou-Atsama, Robert Banai, Laure Ngono and Richard Njouom
    Citation: Virology Journal 2019 16:101
  10. Patients with hepatitis C virus (HCV) genotype 3 infection remain a difficult-to-cure population. This study evaluated the efficacy and safety of sofosbuvir-based regimen in genotype 3 patients in a real-world...

    Authors: Qunying Han, Xiude Fan, Xiaoyun Wang, Ye Wang, Huan Deng, Xiaoge Zhang, Kun Zhang, Na Li and Zhengwen Liu
    Citation: Virology Journal 2019 16:74
  11. The ubiquitin proteasome system (UPS) regulates the expression levels of cellular proteins by ubiquitination of protein substrates followed by their degradation via the proteasome. As a highly conserved cellul...

    Authors: Fanyun Kong, Hongjuan You, Delong Kong, Kuiyang Zheng and Renxian Tang
    Citation: Virology Journal 2019 16:73
  12. Much evidence has demonstrated the influence of Hepatitis B virus (HBV) mutations on the clinical course of HBV infection. As large (L) protein plays a crucial role for viral entry, we hypothesized that mutati...

    Authors: Suguru Ogura, Masahiko Tameda, Kazushi Sugimoto, Makoto Ikejiri, Masanobu Usui, Masaaki Ito and Yoshiyuki Takei
    Citation: Virology Journal 2019 16:59
  13. MicroRNAs (miRNAs) have gained much attention as cellular factors regulating hepatitis C virus (HCV) infection. miR-27b has been shown to regulate HCV infection in the hepatocytes via various mechanisms that h...

    Authors: Fuminori Sakurai, Rina Hashimoto, Chieko Inoue, Keisaku Wakabayashi, Tomohito Tsukamoto, Tsutomu Imaizumi, Taracena Gandara Marcos Andres, Eiko Sakai, Kanae Itsuki, Naoya Sakamoto, Takaji Wakita and Hiroyuki Mizuguchi
    Citation: Virology Journal 2019 16:58
  14. Human pegivirus (HPgV), formally called GB virus C (GBV-C), is a member of the pegivirus genus in Flaviviridae family. High prevalence of HPgV infection is seen among sex workers, blood transfusion recipients ...

    Authors: Wubet Taklual, Shixing Tang and Wu Yue
    Citation: Virology Journal 2019 16:50
  15. Interleukin (IL)-35 regulates imbalance between regulatory T cells (Tregs) and T helper (Th) 17 cells, leading to an important modulator in autoimmune disorder, cancer, and infectious diseases. Our previous st...

    Authors: Lanlan Yang, Shengnan Jia, Xue Shao, Siqi Liu, Qian Zhang, Jie Song, Wudong Wang and Zhenjing Jin
    Citation: Virology Journal 2019 16:48
  16. Hepatitis C virus (HCV) infection is one of the leading causes of liver cancer, creating enormous economic and social burdens. The Chinese government recommends routine screening of inpatients for HCV before i...

    Authors: Lili Liu, Hongqin Xu, Yue Hu, Jia Shang, Jianning Jiang, Lei Yu, Caiyan Zhao, Dazhi Zhang, Xinxin Zhang, Junfeng Li, Wei Li, Yanan Wu, Diefei Hu, Xiaofang Wang, Qian Zhao, Qiongfang Zhang…
    Citation: Virology Journal 2019 16:47
  17. Although vaccines for hepatitis B virus (HBV) are highly effective, HBV infections in vaccinees occur. Index samples of breakthrough infections are typically anti-HBc negative but HBV DNA positive with protect...

    Authors: Mary C. Kuhns, Anne L. McNamara, Vera Holzmayer and Gavin A. Cloherty
    Citation: Virology Journal 2019 16:43
  18. Whether sofosbuvir is suitable for hepatitis C virus (HCV) infected patients with severe renal impairment is inconclusive. This systematic review aims to evaluate the safety and effectiveness of SOF-based regi...

    Authors: Mingshu Li, Jun Chen, Zhixiong Fang, Yi Li and Qian Lin
    Citation: Virology Journal 2019 16:34
  19. HCV exhibits a high genetic diversity and is classified into 7 genotypes which are further divided into 86 confirmed subtypes. However, there are multiple isolates with unassigned subtypes. We aimed to amplify...

    Authors: Bo Wang, Luise Krüger, Patrycja Machnowska, Amare Eshetu, Barbara Gunsenheimer-Bartmeyer, Viviane Bremer, Andrea Hauser, Norbert Bannert and C.-Thomas Bock
    Citation: Virology Journal 2019 16:28
  20. To examine the epidemiological trends and changes of hepatitis E virus (HEV) infection and the potential risk factors for severe infection in the Zhejiang eastern coastal area of China.

    Authors: Jun Tan, Yijuan Chen, Lin Wang, Ta-Chien Chan, Said Amer, Xiaobin Xu, Jian Cai, Wei Li, Xiaoqing Zheng, Mi Zhou, Shuwen Qin, Na Zhao, Ziping Miao and Shelan Liu
    Citation: Virology Journal 2019 16:16
  21. Data on the treatment of patients with hepatitis C virus (HCV)/human immunodeficiency virus (HIV) coinfection remains limited. A comprehensive analysis was performed to evaluate the efficacy and safety of ombi...

    Authors: Jingjing Wu, Peng Huang, Haozhi Fan, Ting Tian, Xueshan Xia, Zuqiang Fu, Yan Wang, Xiangyu Ye, Ming Yue and Yun Zhang
    Citation: Virology Journal 2019 16:11
  22. Men who have sex with men (MSM) are considered to be at significant risk for sexually transmitted infections (STI) and bloodborne viruses including viral hepatitis types B, C, and D (HBV, HCV, and HDV) and hum...

    Authors: Henri Gautier Ouedraogo, Seni Kouanda, Ashley Grosso, Rebecca Compaoré, Modibo Camara, Charlemagne Dabire, Rasmata Ouedraogo, Yves Traore, Stefan Baral and Nicolas Barro
    Citation: Virology Journal 2018 15:194
  23. Hepatitis B virus is a hepatotropic DNA virus that reproduces via an RNA intermediate. It can lead to an increased risk of serious liver diseases such as hepatocellular carcinoma and is a serious threat to pub...

    Authors: Lei Jia, Fengyu Hu, Hanping Li, Lin Li, Xiaoping Tang, Yongjian Liu, Haohui Deng, Jingwan Han, Jingyun Li and Weiping Cai
    Citation: Virology Journal 2018 15:188
  24. The recently approved interferon-free DAA (direct antiviral agents) regimens have shown not only to be effective in terms of sustained virological response (SVR) rates (> 90%) but also well tolerated in most h...

    Authors: Antonio Di Biagio, Lucia Taramasso and Giovanni Cenderello
    Citation: Virology Journal 2018 15:180
  25. In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of ...

    Authors: Bo Wang, Olusola Anuoluwapo Akanbi, Dominik Harms, Olufisayo Adesina, Folakemi Abiodun Osundare, Dhamari Naidoo, Isabel Deveaux, Opeayo Ogundiran, Uzoma Ugochukwu, Nwando Mba, Chikwe Ihekweazu and C.-Thomas Bock
    Citation: Virology Journal 2018 15:163
  26. Transjugular intrahepatic portosystemic shunt (TIPS) procedure has played a vital role in management of portal hypertension. Thus, we aimed to investigate the natural history, long-term clinical outcome, predi...

    Authors: Dengke Teng, Hao Zuo, Lin Liu, Jinghui Dong and Lei Ding
    Citation: Virology Journal 2018 15:151
  27. Chronic hepatitis C virus (HCV) genotype (GT) 3 infection with advanced liver disease has emerged as a challenging to treat by direct-acting antivirals (DAAs), but the efficacy of DAAs in Chinese HCV-GT3 patie...

    Authors: Ya-Chao Tao, Rong Deng, Meng-Lan Wang, Duo-Duo Lv, Man Yuan, Yong-Hong Wang, En-Qiang Chen and Hong Tang
    Citation: Virology Journal 2018 15:150
  28. We evaluated the frequency of naturally occurring resistance associated substitutions (RASs) and their characteristic of polymorphic or non-polymorphic amino acid change to direct acting antivirals (DAAs) in N...

    Authors: Sabrina Bagaglio, Caterina Uberti-Foppa, Alessandro Olgiati, Emanuela Messina, Hamid Hasson, Camilla Ferri and Giulia Morsica
    Citation: Virology Journal 2018 15:144
  29. Burkina Faso is a high endemicity country for HBV infection. However, there are few data on vaccine coverage against HBV. The aim of this study was to contribute to the improvement of HBV vaccine coverage in O...

    Authors: Birama Diarra, Albert Theophane Yonli, Abdoul Karim Ouattara, Theodora Mahoukèdè Zohoncon, Lassina Traore, Christelle Nadembega, Dorcas Obiri-Yeboah, Justine Yara, Virginio Pietra, Paul Ouedraogo, Alain Bougouma, Rokia Sanogo and Jacques Simpore
    Citation: Virology Journal 2018 15:121
  30. A new promising therapeutic approach has emerged for patients chronically infected by the hepatitis B virus (HBV) with the development of a non-replicative adenovirus vector vaccine candidate (Ad-HBV). The vac...

    Authors: Xuefeng Zhang, Jing Wang, Jing Lu, Rongrong Li and Shuli Zhao
    Citation: Virology Journal 2018 15:111

    The Correction to this article has been published in Virology Journal 2018 15:137

  31. A treatment of HCV infection depends on the genotype and sub-genotype. Therefore, accurate HCV genotyping is critical for selecting the appropriate treatment regimen.

    Authors: Shrikant Dasharath Warkad, Satish Balasaheb Nimse, Keum-Soo Song, Wasun Chantratita, Viroj Pongthanapisith, Laxman Uddhav Nawale and Taisun Kim
    Citation: Virology Journal 2018 15:107
  32. Chinese woodchucks (M. himalayana) were recently found to be susceptible to woodchuck hepatitis virus (WHV) infection. In this study, we aimed to determine the susceptibility to WHV infection of M. himalayana fro...

    Authors: Bin Zhu, Zhenni Zhu, Junzhong Wang, Shunmei Huang, Fanghui Li, Lu Wang, Yanan Liu, Qi Yan, Shunchang Zhou, Mengji Lu, Dongliang Yang and Baoju Wang
    Citation: Virology Journal 2018 15:101
  33. Hepatitis B virus (HBV) chronically infects approximately 350 million people worldwide, causing a major risk of liver disease and hepatocellular carcinoma (HCC). Many mouse models have been tried to establish ...

    Authors: Xian Wang, Jianmin Zhu, Yong Zhang, Yue Li, Tai Ma, Qun Li, Jiegou Xu and Long Xu
    Citation: Virology Journal 2018 15:89
  34. Hepatocytes infected by hepatitis B virus (HBV) produce different HBV RNA species, including pregenomic RNA (pgRNA), which is reverse transcribed during replication. Particles containing HBV RNA are present in...

    Authors: Kasthuri Prakash, Gustaf E. Rydell, Simon B. Larsson, Maria Andersson, Gunnar Norkrans, Heléne Norder and Magnus Lindh
    Citation: Virology Journal 2018 15:86
  35. To investigate the predictive capability of microRNAs (miRNAs) prior treatment for HBsAg clearance in chronic hepatitis B (CHB) treated with pegylated interferon α-2a (PEG-IFNα-2a).

    Authors: Yanlin Yang, Ming Liu, Ying Deng, Yan Guo, Xuqing Zhang, Dedong Xiang, Li Jiang, Zhonglan You, Yi Wu, Maoshi Li and Qing Mao
    Citation: Virology Journal 2018 15:73
  36. It has been reported that the emergence of HBV rtA181T/sW172* mutant could result in a dominant secretion defect of HBsAg and increase the risk of HCC development. This study was designed to reveal the role an...

    Authors: Meng-Lan Wang, Dong-Bo Wu, Ya-Chao Tao, Lan-Lan Chen, Cui-Ping Liu, En-Qiang Chen and Hong Tang
    Citation: Virology Journal 2018 15:61
  37. Host single-nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) locus are associated with sustained virological response to antiviral therapy and with spontaneous Hepatitis C Virus (HCV) clearance. P...

    Authors: Natalia Echeverría, Daniela Chiodi, Pablo López, Adriana Sanchez Ciceron, Jenniffer Angulo, Marcelo López-Lastra, Paola Silvera, Adrian Canavesi, Carla Bianchi, Valentina Colistro, Juan Cristina, Nelia Hernandez and Pilar Moreno
    Citation: Virology Journal 2018 15:40
  38. Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of...

    Authors: Ana Carolina Gomes Jardim, Jacqueline Farinha Shimizu, Paula Rahal and Mark Harris
    Citation: Virology Journal 2018 15:34
  39. Simeprevir is approved with pegylated interferon and ribavirin (PR) for chronic hepatitis C virus (HCV) genotype (GT) 1 and GT4 infection in the USA and the European Union.

    Authors: Fabien Zoulim, Christophe Moreno, Samuel S. Lee, Peter Buggisch, Andrzej Horban, Eric Lawitz, Chris Corbett, Oliver Lenz, Bart Fevery, Thierry Verbinnen, Umesh Shukla and Wolfgang Jessner
    Citation: Virology Journal 2018 15:26
  40. Previous published studies have reported conflicting results of association between hepatitis B virus (HBV) infection and preeclampsia. There was no published data on HBV and preeclampsia in Africa including S...

    Authors: Mohamed A. Ahmed, Manal E. Sharif, Duria A. Rayis, Abubakr M. Nasr and Ishag Adam
    Citation: Virology Journal 2018 15:20
  41. The treatment of hepatitis C virus (HCV) in HCV/human immunodeficiency virus (HIV) co-infected patients remains complex. This present meta-analysis evaluated the efficacy and safety of Sofosbuvir (SOF) for tre...

    Authors: Guotao Li, Ke Zang, Guoqiang Zhang, Danyan Zhu and Xiaozhao Deng
    Citation: Virology Journal 2018 15:19
  42. An association between hepatitis C virus (HCV) and type 2 diabetes (T2D) is supported by numerous epidemiologic studies. We hypothesized that HCV could infect human pancreatic islet cells in vitro.

    Authors: Jason T. Blackard, Ling Kong, Angela Lombardi, Dirk Homann, Sara Salehi Hammerstad and Yaron Tomer
    Citation: Virology Journal 2017 14:237
  43. It has been widely accepted that hepatitis B virus X protein (HBx) plays an important role in hepatocellular carcinoma (HCC). This study aimed to explore the function of long non-coding RNAs (lncRNAs) in the e...

    Authors: Yinji Jin, Di Wu, Weiwei Yang, Mingjiao Weng, Yafei Li, Xuefei Wang, Xiao Zhang, Xiaoming Jin and Tianzhen Wang
    Citation: Virology Journal 2017 14:238
  44. Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV) therapy and clearance for a majority of patients, but are not available or effective for all patients. They risk developing HCV-induced...

    Authors: Sara M. Ø. Solbak, Eldar Abdurakhmanov, Anni Vedeler and U. Helena Danielson
    Citation: Virology Journal 2017 14:236
  45. Recently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationshi...

    Authors: Peng Huang, Haozhi Fan, Ting Tian, Peiwen Liao, Jun Li, Rongbin Yu, Xueshan Xia, Yue Feng, Jie Wang, Yuan Liu, Yun Zhang and Ming Yue
    Citation: Virology Journal 2017 14:235