Pharmacokinetic parameter | 1st pharmacokinetic profile | 2nd pharmacokinetic profile | 3rd pharmacokinetic profile |
---|---|---|---|
Tacrolimus co-administered with darunavir/ritonavir (800/100 mg once daily) | |||
C0h (µg/L) | 7.3 | 6.1 | 6.2a |
Cmax (µg/L) | 15.1 | 17.7 | 17.6 |
Tmax (h) | 8 | 4 | 4 |
AUC264h (µg h/L)* | 2647 | 2385 | 2352a |
T1/2 (h) | 227 | 275 | 266 |
CL/F (L/h) | 0.2 | 0.2 | 0.2 |
Tacrolimus co-administered with darunavir/cobicistat (800/150 mg once daily) | |||
C0h (µg/L) | 6.8b | 4.1 | 4.0a |
Cmax (µg/L) | 11.7 | 13.7 | 12.6 |
Tmax (h) | 2 | 8 | 4 |
AUC264h (µg h/L)* | 1747 | 1873 | 1235 |
T1/2 (h) | 226 | 175 | 183 |
CL/F (L/h) | 0.3 | 0.3 | 0.4 |