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Table 3 Assessment of prognostic thresholds of serum IGF-1, H-FABP, and O2 saturation

From: Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severity

TEST

IGF-1

H-FABP

O2 saturation

ROC curve

AUC

0.849

0.9473

0.7618

St. error

0.03811

0.02612

0.04817

95% CI

0.7743–0.9237

0.8961–0.9985

0.6674–0.8562

P-value

P < 0.0001

  

Prognostic threshold

> 25.5 ng/mL

> 19.5 ng/mL

< 94.5%

Sensitivity

73.44% (95% CI 61.52–82.70%)

96.88% (95% CI 89.30–99.44%)

73.44% (95% CI 61.52–82.70%)

Specificity

79.07% (95% CI 64.79–88.58%)

90.7% (95% CI 78.40–96.32%)

72.09% (95% CI 57.31–83.25%)

Fisher’s exact test

PPV

79.07% (95% CI 0.6479–0.8858)

90.70% (95% CI 0.7840–0.9632)

72.09% (95% CI 0.5731–0.8325)

NPV

72.13% (95% CI 0.5983–0.8181)

96.88% (95% CI 0.8930–0.9944)

73.44% (95% CI 0.6152–0.8270)

Sensitivity

66.67% (95% CI 0.5297–0.7803)

95.12% (95% CI 0.8386–0.9913)

64.58% (95% CI 0.5044–0.7657)

Specificity

83.02% (95% CI 0.7077–0.9080)

93.94% (95% CI 0.8543–0.9762)

79.66% (95% CI 0.6773–0.8796)

Relative risk

2.837 (95% CI 1.883–4.443)

29.02 (95% CI 8.445–105.6)

2.714 (95% CI 1.764–4.302)

Odds ratio

9.778 (95% CI 3.970–23.29)

302.3 (95% CI 48.56–1386)

7.142 (95% CI 2.9–16.76)