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Fig. 2 | Virology Journal

Fig. 2

From: MHC class I links with severe pathogenicity in C57BL/6N mice infected with SARS-CoV-2/BMA8

Fig. 2

Effect of BMA8 strain on pathogenicity of infected mice. (A) H&E and immunohistochemical (IHC) staining were performed on the lung tissues of mice. (B) The pathology scores were summarized; 1 point was assigned for each alveolar wall thickening, hemorrhage, cell necrosis, and inflammation. (C) The percentage of NP-positive cells was summarized according to IHC staining in (A). (D) Cytokine concentrations were determined in mice serum at 0 dpi and 3 dpi, including IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, KC/GRO, IFN-γ and TNF-α. *p < 0.05, **p < 0.01, ***p < 0.001, ns means no statistical difference

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