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Table 1 Clinical advances in non-replication structure mRNA vaccines of viral diseases

From: Revolutionizing viral disease vaccination: the promising clinical advancements of non-replicating mRNA vaccines

Virus type

Virus name

Product name

Research and development unit

Coded substances

Delivery systems

Delivery site

ClinicalTrials.gov identifier

Phase

Research progress

Publications

RNA viruses

CHIKV

mRNA-1388(VAL-181388)

Moderna

CHKV-IgG

LNP

Intravenous injection

NCT03325075

I

Completed

-

CHIKV

mRNA-1944

Moderna

CHKV-IgG

LNP

Intravenous injection

NCT03829384

I

Completed

[21]

hMPV、PIV3

mRNA-1653

Moderna

Membrane-anchored fusion glycoproteins of hMPV and PIV3

-

-

NCT03392389

I

Completed

-

hMPV、PIV4

mRNA- 1653

Moderna

Membrane-anchored fusion glycoproteins of hMPV and PIV4

-

-

NCT04144348

I

In test

[143]

H7N9 Influenza virus

VAL-339851(mRNA-1851)

Moderna

H7N9 HA

LNP

Intramuscular injection

NCT03345043

I

Completed

[91]

H10N8 Influenza virus

VAL-506440(mRNA-1440)

Moderna

H10N8 HA

LNP

Intramuscular injection/Intradermal injection

NCT03076385

I

Completed

[92]

Seasonal Influenza Virus

mRNA- 1010

Moderna

H1N1, H3N2 HA, Influenza B virus HA

Intramuscular injection

NCT04956575

I/II

Completed

-

Rabies

CV7201

Curevac

Rabies virus G protein

LNP

Intradermal injection

NCT02241135

I

Completed

[95]

Rabies

CV7202

Curevac

Rabies virus G protein

LNP

Intramuscular injection

NCT03713086

I

Completed

[22]

Rabies

GSK3903133A

GSK

Rabies virus G protein

LNP

_

NCT04062669

I

Test completed, analysis not yet completed

-

RSV

mRNA-1345

Moderna

LNP

_

NCT04528719

I

In test

-

SARS-COVID-2

CVnCoV

Curevac

Spike (S) glycoprotein

LNP

Intramuscular injection

NCT04652102

III

Completed

[75]

SARS-COVID-2

BNT162a1/BNT162b1/BNT162b2/BNT162c2

BioNTech/Pfizer

Spike (S) glycoprotein

LNP

Intramuscular injection

NCT04380701

I/II

In test

-

SARS-COVID-2

BNT162b2

BioNTech/Pfizer

Spike (S) glycoprotein

LNP

Intramuscular injection

NCT04588480

I/II

Completed

[144]

SARS-COVID-2

mRNA-1273

Moderna

Spike (S) glycoprotein

LNP

-

NCT04470427

III

Completed

[145]

Zika

mRNA-1893

Moderna

preM-E with JEV leading sequence

Lipid nanoparticles V1GL

_

NCT04064905

I

Completed

-

Zika

mRNA-1325

Moderna

prM-E

LNP

_

NCT03014089

I

Completed

-

Retrovirus

HIV

iHIVARNA-01

Massachusetts General Hospital、National Institute of Allergy and Infectious Diseases (NIAID)

HTI

DCs

Inguinal Intra-inguinal injection

NCT02413645

I

Completed

[146]

HIV

iHIVARNA-01

Massachusetts General Hospital、National Institute of Allergy and Infectious Diseases (NIAID)

HTI

DCs

Intradermal injection

NCT02888756

II

Completed

[147]

HIV

Massachusetts General Hospital

Gag And Nef

DCs

Intradermal injection

NCT00833781

I/II

Completed

[146]

HIV

mRNA-1644

Moderna/IVA

eOD-GT8 60mer

LNP

Intramuscular injection

NCT05001373

I

In test

-

DNA viruses

HCMV

mRNA-1647/mRNA-1443

Moderna

mRNA-1647: gB, PC pentameric complex; mRNA-1443: pp65

LNP

_

NCT03382405

I

Completed

-

HCMV

mRNA-1647

Moderna

gB, PC pentameric complex

LNP

_

NCT04232280

II

Completed

-

HPV

BNT113

BioNTech

E6 and E7

LNP

Intravenous injection

NCT05448885

II

In test

[113]