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Fig. 9 | Virology Journal

Fig. 9

From: ARIH1 inhibits influenza A virus replication and facilitates RIG-I dependent immune signaling by interacting with SQSTM1/p62

Fig. 9

ARIH1 prevented the interaction between SQSTM1 and RIG-I. A HEK293T cells were co-transfected with pFlag-ARIH1 or its empty plasmid and pHA-SQSTM1 plus Myc-UbWT, and immunoprecipitation assay was performed using HA tag antibody. The polyubiquitination of SQSTM1 was detected by Myc tag antibody. B HEK293T cells were co-transfected with pFlag-RIG-I and pHA-SQSTM1 plus pFlag-ARIH1 or its empty vector, and the interaction between HA-tag SQSTM1 and FLAG-tag RIG-I was detected by immunoprecipitation assay using HA tag antibody

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Virology Journal

ISSN: 1743-422X