Fig. 1

The human skin bacteriophage virome is composed of viral communities with diverse phenotypic and ecological characteristics. Bacteriophage contigs were identified from a metagenomic meta-assembly of human skin virome samples collected from subjects. A Principal component analysis shows annotated bacteriophage genome variation of the 3230 contigs of 1 kb length and longer that were identified as bacteriophage, with 3162 contigs being lytic phage and 68 being lysogenic phage. Of the identified phage, 485 were identified as having a circular conformational genome, and the remaining 2745 phage assemblies had a linear conformation genome. B Bacteriophage contig beta diversity differences are driven by anatomical skin location sampling site and subject differentiation. PCoA plot of Bray Curtis dissimilarity distances of virome samples by location to assess VIBRANT identified bacteriophage beta diversity across sampling site locations. β-diversity clustering was assessed using a PERMANOVA on reported Bray Curtis dissimilarity distances, and it was found that clustering based on both variables subject (P = 0.001, R2 = 0.15102) and location (P = 0.001, R2 = 0.13965) were significant