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Fig. 5 | Virology Journal

Fig. 5

From: Intragenomic rearrangements involving 5′-untranslated region segments in SARS-CoV-2, other betacoronaviruses, and alphacoronaviruses

Fig. 5

A. Intragenomic rearrangement with 5′-UTR sequences present in the intergenic regions between genes encoding p3 and 4a as well as between those encoding p4b and p5 of the Merbecovirus Middle East respiratory syndrome (MERS)-CoV. A segment of the 5′-UTR of the MERS-CoV including TRS-L and part of the second of the two stem-loops is present in the intergenic region between genes encoding p3 and p4a in isolate MG923473 (Burkina Faso, 2015) and between those encoding p4b and p5 affecting the predicted carboxyl-terminal end of ORF4b in isolate MK564475 (Ethiopia, 2017). In the latter case, the last 4 amino acids (HPGF) of ORF4b in the reference MERS-CoV sequence (NC_019843) are replaced by two amino acids (QL). The Q residue is encoded by a cytosine present in the reference sequence (indicated in orange color) and two adenosines incorporated by the 5′-UTR sequence. B. RNA secondary structures of the intergenic region between genes encoding p3 and p4a in MERS-CoV without and with intragenomic rearrangement. Color scheme is as in previous figures

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