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Fig. 3 | Virology Journal

Fig. 3

From: IL-17A plays a critical role in RSV infection in children and mice

Fig. 3

Neutralization of IL-17A alleviates the persistent airway pathophysiology during RSV infection. Mice were treated with neutralizing anti-IL-17A or isotype control antibody on days 14, 16, 18, and 20 post RSV infection. Disease parameters were assessed on day 21. A–B: Levels of IL-17A in BALF. C: Total inflammatory cells isolated from BALF. D: AHR in response to increasing doses of methacholine. E: Representative HE staining and histological scores (HPS) of lung tissues (original Magnification × 200). a: control group (sham-infected and PBS treated mice); b: RSV group (RSV-infected and isotype control antibody-treated mice); c: RSV + anti-IL-17A group (RSV-infected and neutralizing anti-IL-17A antibody-treated mice); d: HPS. Graphs are represented as the mean±sem. Data are representative of two independent experiments performed on 6 animals per group. *P < 0.05, **P < 0.01, ***P < 0.001 shown comparing the control group with the other groups; ^P < 0.05, ^^P < 0.01, shown comparing the RSV group with the RSV + anti-IL-17A group

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