Fig. 1

Comparison of the proportion of positive anti-IFN-γ autoAbs. a Among the severe/critical COVID-19, non-severe COVID-19 patients, and healthy control (HC) subjects, or b between the Chinese and Hispanic/Latino groups in severe/critical COVID-19. p value determined by Chi-square text, *p < 0.05, **p < 0.01. c Age discrimination in quartiles, the third and fourth quartile of age (≧ 50 years) still had a higher proportion of anti-IFN-γ autoAbs compared with other quartiles. p-value determined by Chi-square (CHIDIST), *p < 0.05. d Comparison of anti-IFN-γ auto-Abs titers among three groups of subjects. The horizontal line indicates the median value for each group respectively. The horizontal line in red color indicates the cut-off value of seropositivity for serum anti-IFN-γ autoAbs. *p value < 0.05, versus HC, determined by the Kruskal–Wallis test using a post-hoc Dunn’s test. e Schematic diagram of immunoblotting for confirming the presence of anti-IFN-γ autoAb. Immunoblots presented the binding activity of anti-IFN-γ autoAbs in the tested serum sample from COVID-19 patients or HC