Analysis of 3.5 million SARS-CoV-2 sequences reveals unique mutational trends with consistent nucleotide and codon frequencies

Table 4 SARS-CoV-2 Structural Gene Codon Significant Difference Analysis Highlighting Specific Months

Gene: Codon	Spike: GAT	E: CTG	M: TAC	N: CGA
Month(s) with greatest number of significant differences (summed across all clades)	April, June, and July 2021: 9 differences each	March 2021: 9 differences	May and June 2021: 8 differences each	April and July 2021: 9 differences each
Range of significant p-values (order corresponding to month in cell above)	7.01E⁻⁰⁷-0 5.17E⁻⁰⁶-0 1.12E⁻⁰⁶-0	3.27E⁻⁰⁸-0	3.11E⁻⁰⁸-0 2.85E⁻⁰⁶-0	4.31E⁻⁰⁵-0 1.65E⁻⁰⁹-0
Adjusted alpha (order corresponding to month in first cell)	8.35E⁻⁰⁵ 8.33E⁻⁰⁵ 8.36E⁻⁰⁵	1.47E⁻⁰⁴	9.14E⁻⁰⁵ 9.01E⁻⁰⁵	8.43E⁻⁰⁵ 8.43E⁻⁰⁵

Data from which this table was created can be found in Additional file 7: Table S7 and Additional file 8: Table S8

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