Analysis of 3.5 million SARS-CoV-2 sequences reveals unique mutational trends with consistent nucleotide and codon frequencies

Table 2 SARS-CoV-2 Structural Gene Nucleotide Significant Difference Analysis Highlighting Specific Months

Gene	Spike	E	M	N
Month with greatest number of significant differences (listed -summed across all clades and nucleotides)	July 2021: 38 differences	December 2020: 33 differences	December 2021: 28 differences	April 2021: 38 differences
Range of significant p-values	1.94E⁻⁰⁵–0	0.001–9.75E⁻¹¹⁶	0.001–0	0.001–0
Adjusted alpha	0.0125	0.0014	0.0013	0.0125

Data from which this table was created can be found in Additional file 2: Table S2 and Additional file 3: Table S3

ISSN: 1743-422X