Fig. 3
From: Bafilomycin A1 inhibits SARS-CoV-2 infection in a human lung xenograft mouse model
Baf-A1 inhibits SARS-CoV-2 replication in xenografted human lung tissues vehicle. DMSO or SARS-CoV-2 was injected into the NCG mice engrafted with human lung tissues under 105.5 TCID50. Baf-A1 (0.1 mg/kg) or Remdesivir (15 mg/kg) was intraperitoneally added 2 h before SARS-CoV-2 infection. Then, NCD mice were treated with Baf-A1or Remdesivir on 1, 2, 3, 4, 5 dpi post infection. Five NCD mice per group were sacrificed by cervical dislocation and human lung tissues were isolated for virus titration and RT-qPCR. A Viral titers of the SARS-CoV-2-infected human lung tissues from Baf-A1 or Remdesivir treated mice on 5 dpi. B, C RT-qPCR analysis of SARS CoV-2 N (B) and E gene (C) copies in the Mock, SARS-CoV-2, Baf-A1 or Remdesivir treated human lungs on 5 dpi