Table 1 Clinical characteristics of children with EV infection according to age, Guangzhou, China, 2019
From: Enterovirus B types cause severe infection in infants aged 0–3 months
All cases, n = 115 | 0–3 months, n = 50 | > 3 months, n = 65 | p | |
|---|---|---|---|---|
Age (months) | 10.0 (0.7–19.0) | 0.7 (0.4–0.9) | 17.0 (13.0–26.5) | N.D |
Male sex | 75 (65.2%) | 29 (58.0%) | 46 (70.8%) | N.S |
Days of hospitalization | 6 (4–13) | 13 (7–17) | 5 (4–7) | < 0.001 |
Clinical symptoms | ||||
Fever (≥ 38℃) | 103 (89.6%) | 40 (80.0%) | 63 (96.9%) | 0.003 |
Rash | 60 (52.2%) | 4 (8.0%) | 56 (86.2%) | N.S |
Tachycardiaa | 40 (34.8%) | 10 (20.0%) | 30 (46.2%) | 0.004 |
Lethargy | 2 (1.7%) | 1 (2.0%) | 1 (1.5%) | N.S |
Coughing | 37 (32.2%) | 8 (16.0%) | 29 (44.6%) | 0.001 |
Diarrhea | 23 (20.0%) | 7 (14.0%) | 16 (24.6%) | N.S |
Vomiting | 15 (13%) | 1 (2.0%) | 14 (21.5%) | 0.002 |
Pruritus | 6 (5.2%) | 0 (0.0%) | 6 (9.2%) | N.S |
Startle | 12 (10.4%) | 0 (0.0%) | 12 (18.5%) | 0.001 |
Convulsions | 28 (24.3%) | 2 (4.0%) | 26 (40%) | < 0.001 |
Impaired consciousness | 7 (6.1%) | 5 (10.0%) | 2 (3.1%) | N.S |
Hand-foot-mouth disease | 59 (51.3%) | 1 (2.0%) | 58 (89.2%) | < 0.001 |
Pneumonia | 44 (38.3%) | 34 (68.0%) | 10 (15.4%) | < 0.001 |
Aseptic meningitis | 36 (31.3%) | 28 (56.0%) | 8 (12.3%) | < 0.001 |
Encephalitis | 6 (5.2%) | 3 (6.0%) | 3 (4.6%) | N.S |
Sepsis | 19 (16.5%) | 14 (28.0%) | 5 (7.7%) | 0.004 |
Myocarditis | 11 (9.6%) | 8 (16.0%) | 3 (4.6%) | N.S |
Gastrointestinal dysfunction | 23 (20%) | 11 (22.0%) | 12 (18.5%) | N.S |
Hepatitis | 8 (7.0%) | 6 (12.0%) | 2 (3.1%) | N.S |
Pulmonary edema | 3 (2.6%) | 1 (2.0%) | 2 (3.1%) | N.S |
Severe infection | 62 (53.9%) | 39 (78.0%) | 23 (35.4%) | < 0.001 |
Number of deaths | 2 (1.7%) | 1 (2.0%) | 1 (1.5%) | N.S |