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Fig. 3 | Virology Journal

Fig. 3

From: Reactive oxygen species enhance rAAV transduction by promoting its escape from late endosomes

Fig. 3

Shikonin increased ss-rAAV8 transduction in vivo. NSG mice treated with shikonin or DMSO were given an injection of ss-rAAV8-Fluc vectors via tail vein at 1 × 1011 vg/mouse, with six mice in each group. A 9 days after injection, whole-body bioluminescence imaging was performed on each NSG mouse. B Quantification on mouse bioluminescent signals 1/3/5/7/9 days following ss-rAAV8-Fluc treatment. C 3 days after ss-rAAV8-Fluc administration, ROS content was quantified in the liver by a fluorometer. D 100 ng total DNA from liver was employed to determine the number of vector genome copies in the liver 3 days post-transduction. All values represented are means ± SD (n = 3). *p < 0.05; ****p < 0.0001

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