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Table 4 – Predictive value of the scoring system for significant liver injury in CHB patients with normal ALT levels in validation cohort

From: A noninvasive model discriminating significant histological changes in treatment-naive chronic hepatitis B patients with normal ALT

 

AAPL index

Total

 

< low cut-off (< − 0.207)

Indeterminate (− 0.207 to 0.537)

> high cut-off (> 0.537)

Total

19

22

116

157

G < 2 and S < 2

14

13

13

40

G ≥ 2 or/and S ≥ 2

5

9

103

117

Specificity (%)

35.0

 

67.5

 

Sensitivity (%)

95.7

 

88.0

 

PPV (%)

81.2

 

88.8

 

NPV (%)

73.7

 

65.9

 

Correct prediction rate

(103 + 14)/(116 + 19) = 86.7%

 
  1. A total of 135 (116 + 19) patients were identified by AAPL index, in detail, 116 with and 19 without significant liver injury. Among them, the prediction of 117 (103 + 14) patients were proven correct by hepatic histopathology
  2. CHB chronic hepatitis B, G grading of necroinflammation, S staging of liver fibrosis, PPV positive predictive value, NPV negative predictive value
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Virology Journal

ISSN: 1743-422X