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Table 3 Predictive value of the scoring system for significant liver injury in CHB patients with normal ALT levels in training cohort

From: A noninvasive model discriminating significant histological changes in treatment-naive chronic hepatitis B patients with normal ALT

 

AAPL index

Total

 

< low cut-off (< − 0.207)

Indeterminate (− 0.207 to 0.537)

> high cut-off (> 0.537)

Total

44

54

359

457

G < 2 and S < 2

32

26

35

93

G ≥ 2 or/and S ≥ 2

12

28

324

364

Specificity (%)

34.4

 

62.4

 

Sensitivity (%)

96.7

 

89.0

 

PPV (%)

85.2

 

90.3

 

NPV (%)

72.7

 

59.2

 

Correct prediction rate

(324 + 32)/(359 + 44) = 88.3%

 
  1. A total of 403 (359 + 44) patients were identified by AAPL index, in detail, 359 with and 44 without significant liver injury. Among them, the prediction of 356 (324 + 32) patients were proven correct by hepatic histopathology
  2. CHB chronic hepatitis B, G grading of necroinflammation, S staging of liver fibrosis, PPV positive predictive value, NPV negative predictive value