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Table 2 Variables associated with the significant liver injury in training cohort

From: A noninvasive model discriminating significant histological changes in treatment-naive chronic hepatitis B patients with normal ALT

Variables

Univariate analysis

Multivariate analysis

OR

95%CI

p value

OR

95%CI

p value

Age (years)

1.03

1.01–1.05

0.01

1.04

1.01–1.07

0.005

Height (m)

1.01

0.94–1.04

0.73

   

Weight (kg)

1.02

0.99–1.04

0.14

   

HBV DNA (log10IU/ml)

1.55

1.06–1.98

0.14

   

LS (kPa)

1.88

1.61–2.25

< 0.0001

1.77

1.44–2.06

< 0.0001

AFP (ng/mL)

1.13

1.03–1.29

0.03

   

GGT (IU/L)

1.03

0.99–1.06

0.08

   

TBIL (µmol/L)

1.03

1.00-1.09

0.11

   

TP (mg/L)

1.02

0.98–1.05

0.32

   

BA (µmol/L)

0.99

0.98–1.16

0.64

   

PAB (mg/L)

0.98

0.97–0.99

0.13

   

ALB (g/l)

0.89

0.83–1.04

0.71

   

AKP (IU/L)

1.00

0.99–1.02

0.53

   

ALT (IU/L)

1.06

1.04–1.08

0.001

1.04

1.03–1.09

< 0.0001

AST (IU/L)

1.09

1.06–1.14

0.02

   

DBIL (µmol/L)

1.26

1.04–1.55

0.08

   

PT (s)

1.75

1.30–2.39

0.19

   

INR

2.01

0.90–3.11

0.37

   

PLT (109/L)

1.02

1.01–1.06

0.04

1.01

1.01–1.02

0.02

  1. HBV hepatitis B virus, LS liver stiffness, AFP alpha fetoprotein, GGT gamma-glutamyl transpeptidase, TBIL total bilirubin, TP total protein, BA bile acid, ALB albumin, PAB prealbumin, AKP alkaline phosphatase, ALT alanine transaminase, AST aspartate aminotransferase, DBIL direct bilirubin, PT prothrombin time, INR international normalized ratio, PLT platelet