Table 1 Characteristics of the enrolled cases
Variables at baseline | Total cohort (n = 614) | Training cohort (n = 457) | Validation cohort (n = 157) | ||||||
|---|---|---|---|---|---|---|---|---|---|
G < 2 and S < 2 (n = 93) | G ≥ 2 and/or S ≥ 2 (n = 364) | p value* | Total | G < 2 and S < 2 (n = 40) | G ≥ 2 and/or S ≥ 2 (n = 117) | p value# | Total | ||
Age (years) | 41.0 (10.7) | 38.3 (10.7) | 41.9 (11.2) | 0.02 | 41.2 (11.1) | 39.6 (11.2) | 40.79 (10.5) | 0.04 | 40.3 (10.6) |
Male gender, n (%) | 422 (68.7%) | 63 (67.7%) | 252 (69.2%) | 0.88 | 315 (68.9%) | 27 (67.5%) | 80 (68.4%) | 0.99 | 107 (68.2%) |
Height (m) | 168.3 (7.5) | 168.4 (7.4) | 168.9 (7.5) | 0.40 | 168.4 (7.5) | 167.9 (6.5) | 168.7 (7.8) | 0.57 | 168.3 (7.4) |
Weight (kg) | 67.9 (12.0) | 67.8 (10.5) | 68.1 (12.4) | 0.10 | 67.7 (12.2) | 65.2 (12.3) | 67.9 (11.9) | 0.09 | 67.2 (12.2) |
HBV DNA (log10IU/ml) | 5.0 (2.2) | 5.0 (2.5) | 5.14 (2.0) | 0.73 | 4.9 (2.1) | 5.0 (2.6) | 5.1 (2.0) | 0.79 | 5.1 (2.0) |
LS (kPa) | 8.2 (4.1) | 5.5 (1.5) | 8.9 (4.4) | 0.0001 | 8.3 (4.3) | 4.5 (1.3) | 8.9 (5.0) | 0.0001 | 7.8 (4.6) |
AFP (ng/mL) | 5.2 (5.3) | 5.1 (2.5) | 5.9 (16.6) | 0.26 | 5.4 (69.9) | 4.7 (1.8) | 4.8 (2.2) | 0.31 | 4.8 (6.3) |
GGT (IU/L) | 30.8 (17.1) | 31.3 (16.7) | 32.4 (36.1) | 0.71 | 31.0 (44.9) | 30.3 (20.1) | 30.0 (18.4) | 0.62 | 30.1 (22.8) |
TBIL (µmol/L) | 16.4 (8.7) | 16.9 (6.7) | 17.1 (10.7) | 0.05 | 16.2 (11.8) | 15.9 (8.3) | 17.2 (8.6) | 0.16 | 16.8 (8.5) |
TP (mg/L) | 73.3 (7.2) | 72.6 (4.6) | 73.2 (7.9) | 0.08 | 73.3 (7.0) | 73.6 (4.6) | 73.15 (7.9) | 0.59 | 73.2 (7.2) |
BA (µmol/L) | 8.7 (13.1) | 8.1 (30.6) | 8.3 (11.5) | 0.39 | 8.7 (14.7) | 8.5 (21.5) | 8.6 (19.2) | 0.94 | 8.6 (8.4) |
PAB (mg/L) | 224.0 (48.5) | 214.7 (51.6) | 221.1 (48.2) | 0.12 | 225.3 (49.6) | 229.8 (46.9) | 217.1 (49.8) | 0.12 | 220.4 (49.2) |
ALB (g/l) | 44.4 (4.5) | 45 (3.6) | 44.9 (4.6) | 0.40 | 44.5 (4.5) | 44.4 (3.2) | 44.05 (4.4) | 0.81 | 44.1 (4.2) |
AKP (IU/L) | 74.6 (22.8) | 73.0 (23.9) | 75.0 (18.7) | 0.06 | 74.8 (27.9) | 73.0 (23.1) | 73.5 (26.2) | 0.18 | 73.4 (20.4) |
ALT (IU/L) | 43.2 (24.4) | 29.7 (14.5) | 48.3 (29.5) | 0.0001 | 44.7 (14.3) | 27.53 (13.2) | 43.6 (18.4) | 0.001 | 39.0 (14.5) |
AST (IU/L) | 35.2 (18.9) | 30.6 (20.9) | 35.7 (17.1) | 0.05 | 34.7 (20.2) | 32.4 (21.2) | 35.6 (19.8) | 0.07 | 36.8 (32.9) |
DBIL (µmol/L) | 3.1 (2.1) | 3.1 (1.3) | 3.2 (3.2) | 0.07 | 3.2 (3.5) | 2.7 (1.2) | 3.1 (2.0) | 0.18 | 3.0 (1.85) |
PT (s) | 11.7 (1.1) | 11.5 (0.8) | 11.8 (0.9) | 0.32 | 11.7 (1.0) | 11.6 (0.8) | 11.7 (0.9) | 0.71 | 11.7 (0.9) |
INR | 1.0 (0.5) | 0.9 (0.1) | 1.0 (0.1) | 0.06 | 1.0 (0.1) | 1.0 (0.7) | 1.0 (0.7) | 0.68 | 1.0 (0.7) |
PLT (109/L) | 179.6 (51.1) | 183.9 (46.1) | 176.6 (50.7) | 0.03 | 178.1 (49.1) | 199.6 (51.8) | 179.7 (53.0) | 0.04 | 183.9 (53.4) |
HBeAg+, n (%) | 348 (56.7%) | 51 (54.8%) | 211 (58.0%) | 0.67 | 262 (57.3%) | 22 (55.0%) | 64 (54.7%) | 0.99 | 86 (54.8%) |