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Fig. 2 | Virology Journal

Fig. 2

From: Adaptive immune responses and cytokine immune profiles in humans following prime and boost vaccination with the SARS-CoV-2 CoronaVac vaccine

Fig. 2

CoronaVac vaccine triggered polyfunctional CD4+T cells response with a predominant Th1 and weak Th17 helper response against RBD protein. A, C Representative flow cytometric plots depicting the gating of CD4 and CD8+T cells subset. B, D Frequency of subsets in CD4 and CD8+T cells. E ELISA detected the cytokines from cultural supernatant. F, G Heat map of multifunctional activity profiles of the RBD-specific CD4 and CD8+T cells evaluated on days 40, 180 (two doses) and 60 (three doses). *: P < 0.05, **: P < 0.01, ***: P < 0.001, ns: no significance. Significant difference was calculated by Wilcoxon tests [(B), (D), (E)], and Kruskal–Wallis’s test [(F)]

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