Fig. 3

Microbial mutagenicity test for AYA2012004_L aptamer’s mutagenic potential is assessed by exposing S. typhimurium strains TA98, TA100, TA1535, TA1537 and E. coli strains wp2[pkM101] and wp2 uvrA to varying concentrations of the aptamer as well as positive and negative controls and selecting for the reversion events. AYA2012004_L was used with increasing concentrations from 0.5 to 10 uM. The assay was performed both in presence and absence of metabolic activation, provided by a liver homogenate S9. Data are a representative over three independent experiments. Data are expressed as mean ±SD