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Fig. 5 | Virology Journal

Fig. 5

From: Identification of a neutralizing linear epitope within the VP1 protein of coxsackievirus A10

Fig. 5

In vivo protective efficacy of anti-EP4 double-peptide sera against lethal CV-A10 challenge. The neonatal mice were challenged with 50 × LD50 of CV-A10 virus within 24 h after birth (each group = 10). They were then injected with anti-EP4 double-peptide sera, anti-irrelevant peptide sera, or anti-PBS sera. A Survival curve of the neonatal mice. B Clinical scores of the neonatal mice. The severity of clinical symptoms, from mild to severe, was scored in five grades: 0, healthy; 1, reduced mobility; 2, limb weakness; 3, paralysis; 4, death. The Mantel-Cox log-rank test evaluated the survival rates. The clinical scores were compared using Dunn's multiple-comparison test. ***p < 0.001

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