Table 1 Stabilization effect of excipients on FMDV 146S at 37 °C for 5 h
From: Formulation enhanced the stability of Foot-and-mouth virus and prolonged vaccine storage
Excipients | Concentration (Molarity or % w/v) | Residual 146S (μg/mL) | Degradation rate (%) |
|---|---|---|---|
Trehalose | (1) 5% | 4.8 ± 0.4 | 76 |
(2) 10% | 5.2 ± 0.7 | 74 | |
(3) 20% | 6.5 ± 0.3 | 67 | |
(4) 30% | 7.1 ± 0.5 | 64 | |
NaCl | (1) 100 mM | 4.1 ± 0.1 | 79 |
(2) 200 mM | 5.1 ± 0.1 | 74 | |
(3) 500 mM | 5.7 ± 0.3 | 71 | |
(4) 1 M | 4.7 ± 0.3 | 76 | |
CuSO4·5H2O | (1) 0.5 mM | 5.4 ± 0.1 | 73 |
(2) 1 mM | 4.7 ± 0.2 | 76 | |
(3) 1.5 mM | 5.1 ± 0.2 | 75 | |
(4) 3 mM | 5.8 ± 0.1 | 71 | |
No excipient | 3.5 ± 0.2 | 82 |