Fig. 3
From: An mRNA-based rabies vaccine induces strong protective immune responses in mice and dogs
LVRNA001 induced a cellular immune response in mice. Mice received one (0 d) or two inoculations (0d/7d) with LVRNA001 (1 μg or 5 μg), or Rabvac®. PBS served as negative control. A, B Lymphocytes from the mice in each immunization group were collected. IFN-γ and IL-4 levels in the lymphocytes were detected using ELISAs. C, D TNF-α-producing CD4+ and CD8+ T cells from splenic lymphocytes were measured using flow cytometry. n = 4/group. **, p < 0.01. ***, p < 0.001