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Table 1 Demographic data of patients collected in the three datasets

From: Establishment of early diagnosis models for cervical precancerous lesions using large-scale cervical cancer screening datasets

Patient status

HC2

E6E7

Cobas-all

Cobas-OT

Cobas-HPV16

Cobas-HPV18

No. of women (percentage)

Total patient number

31,954

3269

13,342

13,342

13,342

13,342

HPV positive number

18,878 (59.1%)

370 (11.31%)

3406 (25.5%)

3229 (24.2%)

166 (1.24%)

95 (0.71%)

HPV negative number

13,076 (40.9%)

2899 (88.69%)

9936 (74.4%)

10,113 (75.8%)

13,176 (98.76%)

13,247 (99.29%)

NILM-ACD

25,876 (81%)

2955 (90.40%)

11,760 (88.1%)

   

ASCUS-ACD

2871 (9.0%)

163 (4.98%)

824 (6.1%)

   

ASC-H-ACD

492 (1.5%)

17 (0.52%)

88 (0.6%)

   

LSIL-ACD

2039 (6.4%)

119 (3.64%)

572 (4.2%)

   

HSIL-ACD

676 (2.1%)

15 (0.46%)

98 (0.7%)

   

NILM-POS

13,319 (70.6%)

230 (62.16%)

2233 (65.4%)

2120 (65.6%)

88 (53.0%)

61 (64.2%)

ASCUS-POS

2416 (12.8%)

55 (14.86%)

481 (14.1%)

454 (14.1%)

19 (11.4%)

15 (15.8%)

ASC-H-POS

486 (2.6%)

11 (2.97%)

83 (2.4%)

74 (2.3%)

11 (6.6%)

4 (4.2%)

LSIL-POS

1981 (10.5%)

64 (17.3%)

517 (15.1%)

497 (15.4%)

25 (15.1%)

14 (14.7%)

HSIL-POS

676 (3.6%)

10 (2.7%)

97 (2.8%)

84 (2.6%)

23 (13.9%)

1 (1.1%)

ACD-BV

1095 (3.42%)

102 (3.12%)

450 (3.37%)

198 (1.48%)

9 (0.07%)

6 (0.04%)

ACD-Fungus

645 (2.01%)

129 (3.95%)

309 (2.32%)

82 (0.61%)

10 (0.07%)

4 (0.03%)

 < 30 years (ACD)

1921 (6.01%)

634 (18.39%)

1230 (9.22%)

   

 ≥ 30 years (ACD)

30,033 (93.99%)

2635 (80.61%)

12,112 (90.78%)

   

 < 30 years (POS)

234 (1.24%)

81 (21.9%)

 

149 (4.61%)

26 (15.7%)

23 (24.2%)

 ≥ 30 years (POS)

18,644 (98.8%)

289 (78.1%)

 

3080 (95.4%)

140 (84.3%)

72 (75.8%)

Mean (SD) of HPV assay result values

Total patient number

142.159 (± 2.56)

1.188 (± 0.06)

    

HPV positive number

240.494 (± 4.19)

10.424 (± 0.27)

 

33.117 (± 0.091)

30.143 (± 0.425)

32.045 (± 0.595)

HPV negative number

0.192 (± 0.001)

0.009 (± 0.0009)

    

NILM-ACD

40.390 (± 1.22)

0.724 (± 0.05)

    

ASCUS-ACD

273.412 (± 10.22)

3.985 (± 0.52)

    

ASC-H-ACD

364.209 (± 23.34)

7.786 (± 1.67)

    

LSIL-ACD

984.328 (± 23.21)

7.038 (± 0.70)

    

HSIL-ACD

778.465 (± 29.84)

8.273 (± 1.66)

    

NILM-POS

78.288 (± 2.32)

9.225 (± 0.30)

 

34.354 (± 0.10)

32.656 (± 0.54)

33.543 (± 0.61)

ASCUS-POS

324.864 (± 11.85)

11.767 (± 0.84)

 

32.762 (± 0.24)

30.253 (± 1.11)

31.2 (± 1.42)

ASC-H-POS

368.702 (± 23.56)

11.950 (± 1.42)

 

31.55 (± 0.56)

27.145 (± 0.66)

36.225 (± 1.96)

LSIL-POS

1013.138 (± 23.58)

13.003 (± 0.69)

 

28.876 (± 0.26)

26.368 (± 1.05)

25.429 (± 1.61)

HSIL-POS

778.465 (± 29.84)

12.409 (± 0.92)

 

30.281 (± 0.65)

25.974 (± 0.63)

29.3 (± NA)

ACD-BV

196.805 (± 15.59)

2.047 (± 0.44)

    

ACD-Fungus

138.861 (± 18.14)

1.026 (± 0.28)

    

 < 30 years (ACD)

33.934 (± 5.9273)

1.379 (± 0.1648)

    

 ≥ 30 years (ACD)

149.082 (± 2.6922)

1.142 (± 0.0708)

    

 < 30 years (POS)

277.189 (± 45.689)

10.717 (± 0.6574)

 

31.554 (± 0.4467)

30.612 (± 1.0022)

31.117 (± 1.352)

 ≥ 30 years (POS)

240.034 (± 4.200)

10.341 (± 0.2959)

 

33.192 (± 0.0935)

30.056 (± 0.4699)

32.342 (± 0.657)

Mean (SD) of age

Total patient

44.901 (± 0.0561)

37.597 (± 0.1633)

42.793 (± 0.0840)

45.808 (± 0.1686)

39.012 (± 0.7513)

38.284 (± 1.0675)

  1. ACD all cases dataset result, POS positive dataset result, Cobas-OT results of other 12 high risk HPV types in Cobas dataset, Cobas-all all the HPV types in Cobas dataset, Cobas-HPV16 HPV16 result in Cobas dataset, Cobas-HPV18 HPV18 result in Cobas dataset