Fig. 4
From: Prevalence and pathology of equine parvovirus-hepatitis in racehorses from New York racetracks
Equine parvovirus-hepatitis (EqPV-H) infection in racehorses is associated with hepatitis. (A). Assessment of Case 1 by H&E shows multifocal lobular infiltrates of inflammatory cells (arrowheads), consistent with hepatitis (i). The highlighted region of A shows examples of shrunken necrotic cells associated with inflammatory infiltrates (arrows) (ii). (B). Assessment of Case 2 by ISH shows positive hybridization (arrow) associated with multifocal inflammatory infiltrates (arrowhead) in hepatic lobules (i). The highlighted region of B shows hybridization in a necrotic cell (arrow) associated with multiple small lymphocytes (arrowhead) (ii). (C). Histologic evidence of hepatitis was higher in EqPV-H PCR-positive cases compared to EqPV-H PCR-negative controls. (D). Histologic evidence of individual hepatocyte necrosis was higher in EqPV-H PCR-positive cases compared to EqPV-H PCR-negative controls. Scale bar A(i) and B(i) = 200 μm; A(ii) = 20 μm; B(ii) = 10 μm. ***: p = 0.0005; ****: p < 0.0001