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Fig. 3 | Virology Journal

Fig. 3

From: HPV 16 E7 alters translesion synthesis signaling

Fig. 3

Exogenous nucleoside supplementation decreases replication stress and TLS activation in cervical cancer cell lines. Representative immunoblots of cervical cancer cell lines (HeLa and SiHa) probed for A a marker of replication stress (p-ATR) and TLS pathway activation (ub-PCNA) along with total levels of each of these proteins and B representative TLS proteins. Whether the cell lines were grown in media supplemented with exogenous nucleosides is indicated below the immunoblot image with “ + ” indicating nucleosides were added and “−“ indicating that they were not. GAPDH and Nucleolin were used as loading controls

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